Interdisciplinary Research Network on Biologically Active Tau Aggregate Polymorphs from Alzheimer's Disease and Related Dementias
阿尔茨海默病和相关痴呆症生物活性 Tau 聚集多晶型跨学科研究网络
基本信息
- 批准号:10436894
- 负责人:
- 金额:$ 154.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-01 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAlzheimer&aposs DiseaseAlzheimer&aposs disease pathologyAlzheimer&aposs disease related dementiaAmyloid beta-ProteinAntibodiesAppearanceAreaAtomic Force MicroscopyBiochemicalBiologicalBiological ModelsCentrifugationCharacteristicsChemicalsClinicalCommunitiesCryoelectron MicroscopyDetectionDiagnosisDiseaseDisease VectorsElectronsFilamentFluorescence MicroscopyGenetic PolymorphismGoalsHigh PrevalenceHigher Order Chromatin StructureHumanImmunologicsInterdisciplinary StudyLesionMass Spectrum AnalysisMeasurementMethodsMissionMolecularMorphologyNerve DegenerationNeurodegenerative DisordersPathogenesisPathologyPeptide HydrolasesPick Disease of the BrainPolymorphPost-Translational Protein ProcessingPreparationProgressive Supranuclear PalsyProteinsProteomicsProtocols documentationRadioReagentRecombinantsReproducibilityResearchResearch SupportResourcesRoleSamplingSeedsSeverity of illnessSourceSpecimenStagingStandardizationStructureSurrogate MarkersTauopathiesTissuesToxic effectValidationalpha synucleinanimal tissuebiophysical analysisbrain tissuecomorbiditycorticobasal degenerationdiagnostic signaturedisease diagnosishuman diseasehuman tissueinnovationnovel diagnosticsnovel therapeutic interventionprotein TDP-43protein aggregationsynaptic functiontau Proteinstau aggregationtooltransmission process
项目摘要
PROJECT SUMMARY
Tau aggregation is a shared pathology of Alzheimer's disease and related dementias known as tauopathies.
Because each disorder develops a unique combination of aggregate polymorphisms and co-morbidities that may
influence the course and severity of disease, elucidating the relationship between tau aggregate structure and
biological activity has become a high priority in the field. Advances to date have been limited, however, by the
lack of rigorously standardized aggregate preparations from each form of tauopathy and by the absence of tools
needed to selectively detect their presence in biological models and clinical specimens. The proposed
Interdisciplinary Research Network on Biologically Active Tau Aggregate Polymorphs seeks to address this need
by (1) isolating a full range of biologically active tau aggregates from authentic Alzheimer's disease, Corticobasal
Degeneration, Progressive Supranuclear Palsy, and Pick's disease brain tissue, (2) establishing their structures
through biophysical analysis, (3) developing probe sets for their selective detection, and (4) disseminating
reliably vetted samples and lab-ready protocols for their handling and storage to the broader research
community. In accomplishing these goals, the network will support research into the molecular basis of tauopathy
pathogenesis and catalyze efforts toward creating novel diagnostic and therapeutic strategies specifically tailored
against toxic tau aggregate polymorphs.
项目摘要
Tau聚集是阿尔茨海默病和相关痴呆症的共同病理学,称为Tau病。
因为每种疾病都有一种独特的聚合多态性和共病组合,
影响疾病的进程和严重程度,阐明tau聚集体结构与
生物活性已成为该领域的高度优先事项。然而,迄今为止的进展有限,
缺乏来自每种形式的tau蛋白病的严格标准化的聚集体制剂,
需要选择性地检测它们在生物模型和临床标本中的存在。拟议
生物活性Tau聚合物多态性跨学科研究网络旨在解决这一需求
通过(1)从真正的阿尔茨海默氏病、皮质基底神经病和阿尔茨海默病中分离全系列的生物活性tau聚集体,
变性、进行性核上性麻痹和皮克病脑组织,(2)建立其结构
通过生物物理分析,(3)开发用于其选择性检测的探针组,以及(4)传播
可靠地审查样品和实验室准备协议,用于更广泛的研究
社区在实现这些目标的过程中,该网络将支持研究tau蛋白病的分子基础。
发病机制和催化努力创造新的诊断和治疗策略,
针对有毒的tau聚集体多晶型物。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('DAVID EISENBERG', 18)}}的其他基金
Towards Treatment of Alzheimer’s Disease by Targeting Pathogenic Tau and Beta-Amyloid Structures
通过靶向致病性 Tau 和 β-淀粉样蛋白结构来治疗阿尔茨海默病
- 批准号:
10370874 - 财政年份:2022
- 资助金额:
$ 154.49万 - 项目类别:
Towards Treatment of Alzheimer’s Disease by Targeting Pathogenic Tau and Beta-Amyloid Structures
通过靶向致病性 Tau 和 β-淀粉样蛋白结构来治疗阿尔茨海默病
- 批准号:
10544785 - 财政年份:2022
- 资助金额:
$ 154.49万 - 项目类别:
Interdisciplinary Research Network on Biologically Active Tau Aggregate Polymorphs from Alzheimer's Disease and Related Dementias
阿尔茨海默病和相关痴呆症生物活性 Tau 聚集多晶型跨学科研究网络
- 批准号:
10209753 - 财政年份:2021
- 资助金额:
$ 154.49万 - 项目类别:
Interdisciplinary Research Network on Biologically Active Tau Aggregate Polymorphs from Alzheimer's Disease and Related Dementias
阿尔茨海默病和相关痴呆症生物活性 Tau 聚集多晶型跨学科研究网络
- 批准号:
10657390 - 财政年份:2021
- 资助金额:
$ 154.49万 - 项目类别:
Towards Treatment of Alzheimer’s Disease by Targeting Pathogenic Tau and Beta-Amyloid Structures
通过靶向致病性 Tau 和 β-淀粉样蛋白结构来治疗阿尔茨海默病
- 批准号:
10330046 - 财政年份:2021
- 资助金额:
$ 154.49万 - 项目类别:
TRD1: Dedicated sample preparation for MicroED
TRD1:MicroED 专用样品制备
- 批准号:
10155527 - 财政年份:2020
- 资助金额:
$ 154.49万 - 项目类别:
TRD1: Dedicated sample preparation for MicroED
TRD1:MicroED 专用样品制备
- 批准号:
10641815 - 财政年份:2020
- 资助金额:
$ 154.49万 - 项目类别:
TRD1: Dedicated sample preparation for MicroED
TRD1:MicroED 专用样品制备
- 批准号:
10460922 - 财政年份:2020
- 资助金额:
$ 154.49万 - 项目类别:
Structure and Inhibition of Amyloid in Alzheimer's Disease
阿尔茨海默病中淀粉样蛋白的结构和抑制
- 批准号:
9194224 - 财政年份:2016
- 资助金额:
$ 154.49万 - 项目类别:
Development of inhibitors for systemic amyloid diseases
系统性淀粉样蛋白疾病抑制剂的开发
- 批准号:
9428606 - 财政年份:2014
- 资助金额:
$ 154.49万 - 项目类别:














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