Interdisciplinary Research Network on Biologically Active Tau Aggregate Polymorphs from Alzheimer's Disease and Related Dementias

阿尔茨海默病和相关痴呆症生物活性 Tau 聚集多晶型跨学科研究网络

基本信息

  • 批准号:
    10436894
  • 负责人:
  • 金额:
    $ 154.49万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-07-01 至 2026-06-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Tau aggregation is a shared pathology of Alzheimer's disease and related dementias known as tauopathies. Because each disorder develops a unique combination of aggregate polymorphisms and co-morbidities that may influence the course and severity of disease, elucidating the relationship between tau aggregate structure and biological activity has become a high priority in the field. Advances to date have been limited, however, by the lack of rigorously standardized aggregate preparations from each form of tauopathy and by the absence of tools needed to selectively detect their presence in biological models and clinical specimens. The proposed Interdisciplinary Research Network on Biologically Active Tau Aggregate Polymorphs seeks to address this need by (1) isolating a full range of biologically active tau aggregates from authentic Alzheimer's disease, Corticobasal Degeneration, Progressive Supranuclear Palsy, and Pick's disease brain tissue, (2) establishing their structures through biophysical analysis, (3) developing probe sets for their selective detection, and (4) disseminating reliably vetted samples and lab-ready protocols for their handling and storage to the broader research community. In accomplishing these goals, the network will support research into the molecular basis of tauopathy pathogenesis and catalyze efforts toward creating novel diagnostic and therapeutic strategies specifically tailored against toxic tau aggregate polymorphs.
项目总结

项目成果

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DAVID EISENBERG其他文献

DAVID EISENBERG的其他文献

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{{ truncateString('DAVID EISENBERG', 18)}}的其他基金

Towards Treatment of Alzheimer’s Disease by Targeting Pathogenic Tau and Beta-Amyloid Structures
通过靶向致病性 Tau 和 β-淀粉样蛋白结构来治疗阿尔茨海默病
  • 批准号:
    10370874
  • 财政年份:
    2022
  • 资助金额:
    $ 154.49万
  • 项目类别:
Towards Treatment of Alzheimer’s Disease by Targeting Pathogenic Tau and Beta-Amyloid Structures
通过靶向致病性 Tau 和 β-淀粉样蛋白结构来治疗阿尔茨海默病
  • 批准号:
    10544785
  • 财政年份:
    2022
  • 资助金额:
    $ 154.49万
  • 项目类别:
Interdisciplinary Research Network on Biologically Active Tau Aggregate Polymorphs from Alzheimer's Disease and Related Dementias
阿尔茨海默病和相关痴呆症生物活性 Tau 聚集多晶型跨学科研究网络
  • 批准号:
    10209753
  • 财政年份:
    2021
  • 资助金额:
    $ 154.49万
  • 项目类别:
Interdisciplinary Research Network on Biologically Active Tau Aggregate Polymorphs from Alzheimer's Disease and Related Dementias
阿尔茨海默病和相关痴呆症生物活性 Tau 聚集多晶型跨学科研究网络
  • 批准号:
    10657390
  • 财政年份:
    2021
  • 资助金额:
    $ 154.49万
  • 项目类别:
Towards Treatment of Alzheimer’s Disease by Targeting Pathogenic Tau and Beta-Amyloid Structures
通过靶向致病性 Tau 和 β-淀粉样蛋白结构来治疗阿尔茨海默病
  • 批准号:
    10330046
  • 财政年份:
    2021
  • 资助金额:
    $ 154.49万
  • 项目类别:
TRD1: Dedicated sample preparation for MicroED
TRD1:MicroED 专用样品制备
  • 批准号:
    10155527
  • 财政年份:
    2020
  • 资助金额:
    $ 154.49万
  • 项目类别:
TRD1: Dedicated sample preparation for MicroED
TRD1:MicroED 专用样品制备
  • 批准号:
    10641815
  • 财政年份:
    2020
  • 资助金额:
    $ 154.49万
  • 项目类别:
TRD1: Dedicated sample preparation for MicroED
TRD1:MicroED 专用样品制备
  • 批准号:
    10460922
  • 财政年份:
    2020
  • 资助金额:
    $ 154.49万
  • 项目类别:
Structure and Inhibition of Amyloid in Alzheimer's Disease
阿尔茨海默病中淀粉样蛋白的结构和抑制
  • 批准号:
    9194224
  • 财政年份:
    2016
  • 资助金额:
    $ 154.49万
  • 项目类别:
Development of inhibitors for systemic amyloid diseases
系统性淀粉样蛋白疾病抑制剂的开发
  • 批准号:
    9428606
  • 财政年份:
    2014
  • 资助金额:
    $ 154.49万
  • 项目类别:
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