Development of a smartphone-based device to detect fluid overload among postpartum women with hypertensive disorders of pregnancy

开发基于智能手机的设备来检测患有妊娠期高血压疾病的产后妇女的液体超负荷

• 批准号: 10437610
• 负责人: Alisse Hauspurg
• 金额: $ 15.15万
• 依托单位: MAGEE-WOMEN'S RES INST AND FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10437610
• 关键词: Accelerometer; Address; Adherence; Algorithms; Ambulatory Monitoring; Blood Pressure; Blood Pressure Monitors; Blood Volume; Breathing; Cardiovascular system; Caring; Cellular Phone; Congestive; Coupled; Cues; Data; Development; Devices; Diuresis; Echocardiography; Effectiveness; Fluid overload; Future; Goals; Heart failure; Home; Home Blood Pressure Monitoring; Hospitals; Hypertension; Institution; Lead; Left; Liquid substance; Lung; Maternal Mortality; Measures; Mission; Modeling; Monitor; Morbidity - disease rate; Optic Nerve; Outpatients; Patient Education; Patients; Photoplethysmography; Physiologic pulse; Physiological; Population; Postpartum Hypertension; Postpartum Period; Postpartum Women; Pre-Eclampsia; Public Health; Randomized Controlled Trials; Research; Seizures; Starling (law); Stroke; Sturnus vulgaris; Symptoms; Technology; Testing; Tidal Volume; Time; United States; United States National Institutes of Health; Variant; Ventricular; Woman; aggressive therapy; base; blood pressure elevation; blood pressure reduction; cohort; design; disability; disparities in morbidity; disparity reduction; effective intervention; evidence base; experience; health care disparity; hospital readmission; hypertension treatment; improved; indexing; innovation; maternal morbidity; mortality; novel; novel strategies; postpartum care; pregnancy disorder; pregnancy hypertension; pressure; programs; prospective; randomized trial; remote assessment; respiratory; response; sensor; smartphone based assessment; treatment program; ultrasound

PROJECT ABSTRACT Hypertensive disorders of pregnancy contribute to a significant proportion of maternal morbidity and mortality and are the most common reason for hospital readmission postpartum. While treatment of hypertension is the cornerstone of postpartum management, emerging evidence suggests that implementation of robust remote blood pressure monitoring and treatment programs alone do not reduce maternal morbidity or hospital readmissions related to postpartum fluid overload and heart failure symptoms. The ability to predict which women will develop these complications and pursue more aggressive treatment with diuresis prior to hospital discharge or in the first week postpartum is limited. The overall goal of this line of research is to develop and implement a convenient congestion prediction device for home use in conjunction with home blood pressure monitoring in a postpartum population following a hypertensive disorder of pregnancy. In this application, the objective is to develop and test a smartphone-based device to predict fluid overload in patients with preeclampsia through three specific aims: 1) to build multiple smartphone-based devices to assess volume status via a congestion prediction index in postpartum women with preeclampsia, 2) to collect patient training data with the devices, optimize their accuracy in assessing volume status, and identify and create the final real-time device and 3) to validate the final device prospectively in response to known fluid changes among a new cohort of postpartum women with preeclampsia. The research proposed in this application is innovative in its novel adaptation of evidence-based approaches to fluid assessment in heart failure patients to an understudied postpartum population with significant morbidity, its use of a smartphone form factor and the design and the proposed testing of multiple devices to optimize effectiveness and convenience. This proposal is significant as it will provide an opportunity to develop and assess the feasibility of smartphone- based assessment of fluid status among postpartum women with preeclampsia. Effective interventions to improve postpartum hypertension care coupled with innovative remote strategies have broad implications for improving maternal morbidity and reducing disparities in care. Our findings will provide a valuable framework to inform a future randomized trial of remote assessment and management of fluid status in the postpartum period. Successful completion of this line of research would represent a transformation in postpartum management of women with preeclampsia and have a direct impact to improve hypertension and cardiovascular-related maternal morbidity and mortality.

项目摘要