Development of a smartphone-based device to detect fluid overload among postpartum women with hypertensive disorders of pregnancy
开发基于智能手机的设备来检测患有妊娠期高血压疾病的产后妇女的液体超负荷
基本信息
- 批准号:10437610
- 负责人:
- 金额:$ 15.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-01 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:AccelerometerAddressAdherenceAlgorithmsAmbulatory MonitoringBlood PressureBlood Pressure MonitorsBlood VolumeBreathingCardiovascular systemCaringCellular PhoneCongestiveCoupledCuesDataDevelopmentDevicesDiuresisEchocardiographyEffectivenessFluid overloadFutureGoalsHeart failureHomeHome Blood Pressure MonitoringHospitalsHypertensionInstitutionLeadLeftLiquid substanceLungMaternal MortalityMeasuresMissionModelingMonitorMorbidity - disease rateOptic NerveOutpatientsPatient EducationPatientsPhotoplethysmographyPhysiologic pulsePhysiologicalPopulationPostpartum HypertensionPostpartum PeriodPostpartum WomenPre-EclampsiaPublic HealthRandomized Controlled TrialsResearchSeizuresStarling (law)StrokeSturnus vulgarisSymptomsTechnologyTestingTidal VolumeTimeUnited StatesUnited States National Institutes of HealthVariantVentricularWomanaggressive therapybaseblood pressure elevationblood pressure reductioncohortdesigndisabilitydisparities in morbiditydisparity reductioneffective interventionevidence baseexperiencehealth care disparityhospital readmissionhypertension treatmentimprovedindexinginnovationmaternal morbiditymortalitynovelnovel strategiespostpartum carepregnancy disorderpregnancy hypertensionpressureprogramsprospectiverandomized trialremote assessmentrespiratoryresponsesensorsmartphone based assessmenttreatment programultrasound
项目摘要
PROJECT ABSTRACT
Hypertensive disorders of pregnancy contribute to a significant proportion of maternal morbidity
and mortality and are the most common reason for hospital readmission postpartum. While
treatment of hypertension is the cornerstone of postpartum management, emerging evidence
suggests that implementation of robust remote blood pressure monitoring and treatment
programs alone do not reduce maternal morbidity or hospital readmissions related to
postpartum fluid overload and heart failure symptoms. The ability to predict which women will
develop these complications and pursue more aggressive treatment with diuresis prior to
hospital discharge or in the first week postpartum is limited. The overall goal of this line of
research is to develop and implement a convenient congestion prediction device for home use
in conjunction with home blood pressure monitoring in a postpartum population following a
hypertensive disorder of pregnancy. In this application, the objective is to develop and test a
smartphone-based device to predict fluid overload in patients with preeclampsia through three
specific aims: 1) to build multiple smartphone-based devices to assess volume status via a
congestion prediction index in postpartum women with preeclampsia, 2) to collect patient
training data with the devices, optimize their accuracy in assessing volume status, and identify
and create the final real-time device and 3) to validate the final device prospectively in response
to known fluid changes among a new cohort of postpartum women with preeclampsia. The
research proposed in this application is innovative in its novel adaptation of evidence-based
approaches to fluid assessment in heart failure patients to an understudied postpartum
population with significant morbidity, its use of a smartphone form factor and the design and the
proposed testing of multiple devices to optimize effectiveness and convenience. This proposal is
significant as it will provide an opportunity to develop and assess the feasibility of smartphone-
based assessment of fluid status among postpartum women with preeclampsia. Effective
interventions to improve postpartum hypertension care coupled with innovative remote
strategies have broad implications for improving maternal morbidity and reducing disparities in
care. Our findings will provide a valuable framework to inform a future randomized trial of
remote assessment and management of fluid status in the postpartum period. Successful
completion of this line of research would represent a transformation in postpartum management
of women with preeclampsia and have a direct impact to improve hypertension and
cardiovascular-related maternal morbidity and mortality.
项目摘要
妊娠期高血压疾病是造成孕产妇死亡的重要原因
和死亡率,并且是产后再入院的最常见原因。而
治疗高血压是产后管理的基石,新兴证据
建议实施强大的远程血压监测和治疗
计划本身并不能减少孕产妇发病率或与之相关的再入院率。
产后体液过多和心力衰竭症状。预测哪些女性会
出现这些并发症,并在
出院或产后第一周是有限的。这条路线的总体目标是
研究开发一种方便的家用交通拥堵预测装置
结合产后人群的家庭血压监测,
妊娠期高血压疾病。在这个应用程序中,目标是开发和测试一个
基于智能手机的设备通过三种方法预测先兆子痫患者的液体超负荷
具体目标:1)构建多个基于智能手机的设备,通过
先兆子痫产后妇女充血预测指数,2)收集患者
使用设备训练数据,优化其评估容量状态的准确性,并识别
并创建最终实时设备,以及3)作为响应,前瞻性地验证最终设备
一组新的先兆子痫产后妇女中已知的液体变化。的
在这项申请中提出的研究是创新的,在其新的适应证据为基础的
对心力衰竭患者进行液体评估的方法
具有显著发病率的人群,其使用智能手机的形状因素和设计,
建议测试多个设备,以优化有效性和便利性。这项建议是
重要的是,它将提供一个机会,开发和评估智能手机的可行性-
子痫前期妇女产后液体状态的评估。有效
干预措施,以改善产后高血压护理加上创新的远程
这些战略对降低孕产妇发病率和减少
在乎我们的研究结果将提供一个有价值的框架,为未来的随机试验提供信息。
远程评估和管理产后期间的液体状态。成功
这项研究的完成将代表产后管理的转变
对改善高血压有直接影响,
心血管相关的孕产妇发病率和死亡率。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Alisse Hauspurg其他文献
Alisse Hauspurg的其他文献
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{{ truncateString('Alisse Hauspurg', 18)}}的其他基金
Postpartum low-dose aspirin to augment vascular recovery following a hypertensive disorder of pregnancy
产后小剂量阿司匹林可促进妊娠高血压疾病后的血管恢复
- 批准号:
10644089 - 财政年份:2023
- 资助金额:
$ 15.15万 - 项目类别:
Development of a smartphone-based device to detect fluid overload among postpartum women with hypertensive disorders of pregnancy
开发基于智能手机的设备来检测患有妊娠期高血压疾病的产后妇女的液体超负荷
- 批准号:
10196326 - 财政年份:2021
- 资助金额:
$ 15.15万 - 项目类别:
Development of a smartphone-based device to detect fluid overload among postpartum women with hypertensive disorders of pregnancy
开发基于智能手机的设备来检测患有妊娠期高血压疾病的产后妇女的液体超负荷
- 批准号:
10622547 - 财政年份:2021
- 资助金额:
$ 15.15万 - 项目类别:
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