Extension of a longitudinal cognitive and brain imaging study of early-treated perinatally HIV infected children through adolescence

对早期治疗的围产期艾滋病毒感染儿童至青春期的纵向认知和脑成像研究的扩展

基本信息

  • 批准号:
    10437585
  • 负责人:
  • 金额:
    $ 49万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-10 至 2024-06-30
  • 项目状态:
    已结题

项目摘要

Project Summary While the Eastern and Southern African region is home to 6.2% of the world's population, more than half the world's HIV infected people live here. The biggest epidemic is in South Africa, with 7.2 million people living with HIV. Although the rate of new infections has decreased dramatically worldwide from the peak in 1996, one third (270,000) of new infections in Sub-Saharan Africa last year occurred in South Africa. Young adults are disproportionately affected, with 37% of new infections in South Africa occurring in young women between the ages of 15 and 24. Youth are similarly more likely to be infected in the United States. Adolescence represents a critical period of brain maturation, with ongoing myelination, cortical growth and synaptic pruning. Gradual and differential maturation of the limbic system and prefrontal cortex modulates reward and affective behavior, and executive control. HIV infection and ART present further challenges to neurodevelopment and resilience in this vulnerable stage of development. Cognitive impairment in HIV infected children has been demonstrated in several domains, including memory, attention, and general intellectual functioning. There is an urgent need for research on the longitudinal trajectory of neurodevelopment in perinatally-acquired HIV infected (PHIV+) children and adolescents, especially in resource-limited countries. In this study, we will extend our longitudinal follow-up of two extremely well-characterized PHIV+ cohorts, adding neuroimaging and cognitive assessments at 14 and 16 years, and continuing 6-monthly clinical visits. The study will include 80 PHIV+ children from the “Children with HIV early antiretroviral therapy” (CHER) trial, originally supported by the Comprehensive International Program for Research on AIDS in South Africa (CIPRA-SA). Controls were recruited by a CIPRA-SA supported interlinking vaccine trial. This cohort has been followed clinically since birth, and with cognitive assessments and neuroimaging from the age of 5. The cohort incorporates children who commenced ART before 12 weeks, and children whose treatment was delayed until immunological criteria were met. We will also include 30 PHIV+ children from the IMPAACT (International Maternal Pediatric Adolescent AIDS Clinical Trials Network) P1060 and P1104S studies who started ART at 2 to 36 months after exhibiting relatively advanced disease, and uninfected controls from the same cohort. The Cape Universities Body Imaging Centre (CUBIC) houses a state-of-the-art research-dedicated Siemens 3 T Skyra MRI scanner optimized for brain imaging, and unique in sub-Saharan Africa. We have developed the capability for advanced brain morphometry, spectroscopy, diffusion tensor and functional imaging. This project builds on a successful decade-long collaboration between Dr. Ernesta Meintjes (University of Cape Town), Dr. Barbara Laughton (Stellenbosch University) and Dr. André van der Kouwe (Massachusetts General Hospital). The project will build capacity including analysis methods for dynamic functional imaging and advanced spectroscopic imaging techniques.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Barbara Laughton其他文献

Barbara Laughton的其他文献

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{{ truncateString('Barbara Laughton', 18)}}的其他基金

Neural correlates of in utero HIV and ART exposure: early childhood follow-up of a prospectively recruited cohort
子宫内 HIV 和 ART 暴露的神经相关性:前瞻性招募队列的儿童早期随访
  • 批准号:
    10751757
  • 财政年份:
    2023
  • 资助金额:
    $ 49万
  • 项目类别:
Extension of a longitudinal cognitive and brain imaging study of early-treated perinatally HIV infected children through adolescence
对早期治疗的围产期艾滋病毒感染儿童至青春期的纵向认知和脑成像研究的扩展
  • 批准号:
    10654622
  • 财政年份:
    2019
  • 资助金额:
    $ 49万
  • 项目类别:
Extension of a longitudinal cognitive and brain imaging study of early-treated perinatally HIV infected children through adolescence
对早期治疗的围产期艾滋病毒感染儿童至青春期的纵向认知和脑成像研究的扩展
  • 批准号:
    10013263
  • 财政年份:
    2019
  • 资助金额:
    $ 49万
  • 项目类别:
Extension of a longitudinal cognitive and brain imaging study of early-treated perinatally HIV infected children through adolescence
对早期治疗的围产期艾滋病毒感染儿童至青春期的纵向认知和脑成像研究的扩展
  • 批准号:
    10202685
  • 财政年份:
    2019
  • 资助金额:
    $ 49万
  • 项目类别:
Neonatal imaging as an early marker of neurodevelopment and predictor of cognitive performance in infants exposed to HIV and ART in utero and perinatally
新生儿成像作为子宫内和围产期接触 HIV 和 ART 的婴儿神经发育的早期标志和认知表现的预测因子
  • 批准号:
    9199891
  • 财政年份:
    2016
  • 资助金额:
    $ 49万
  • 项目类别:
Neonatal imaging as an early marker of neurodevelopment and predictor of cognitive performance in infants exposed to HIV and ART in utero and perinatally
新生儿成像作为子宫内和围产期接触 HIV 和 ART 的婴儿神经发育的早期标志和认知表现的预测因子
  • 批准号:
    9352865
  • 财政年份:
    2016
  • 资助金额:
    $ 49万
  • 项目类别:
Longitudinal Neuroimaging and Cognitive Study of HIV-Infected Children
HIV 感染儿童的纵向神经影像和认知研究
  • 批准号:
    8487425
  • 财政年份:
    2011
  • 资助金额:
    $ 49万
  • 项目类别:
Longitudinal Neuroimaging and Cognitive Study of HIV-Infected Children
HIV 感染儿童的纵向神经影像和认知研究
  • 批准号:
    8338898
  • 财政年份:
    2011
  • 资助金额:
    $ 49万
  • 项目类别:
Technology development and neuroimaging for 5 year old children with HIV infectio
5 岁 HIV 感染儿童的技术开发和神经影像学
  • 批准号:
    8333355
  • 财政年份:
    2011
  • 资助金额:
    $ 49万
  • 项目类别:
Technology development and neuroimaging for 5 year old children with HIV infectio
5 岁 HIV 感染儿童的技术开发和神经影像学
  • 批准号:
    8133656
  • 财政年份:
    2011
  • 资助金额:
    $ 49万
  • 项目类别:

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