Real time Dual Laser Raman Reactor Analyser with Probe for key inorganic nutrients inside Microalgae Bioreactors

生物反应器被广泛应用于各种工艺中，如食品和食品配料、化学品和药物化合物。这些生物反应器使用广泛的具体分析技术进行监测，这些技术通常需要采样，或者它们只是针对单个参数。这是一个漫长和耗时的过程，要分析优化这一过程所需的因素。在某些情况下，使用危险试剂进行分析是必要的。市场对在线、操作简单、免采样、自动分析技术感兴趣，以实时监控反应堆内过程的性能。与使用单通道设置相比，能够使用两个激光波长进行拉曼光谱，将允许轻松而有效地定制用于监测反应器的更广泛反应的化学计量学模型。与正确的营养剂量相关的反应器使用的优化将以较低的投入成本带来更高的产品产量。ELODIZ是一家专门提供基于光谱的分析解决方案的公司，该公司的目标是引入一种基于拉曼光谱的传感器，用于在线监测生物反应器上的营养物质。该项目的重点是通过单探头的多通道双激光拉曼装置对硝酸盐和磷酸盐进行量化。使用最佳拉曼设置监测这些关键无机营养素的浓度，可以优化它们的浓度，以保持所需产品成功形成的最佳水平。ELODIZ将与布鲁内尔大学合作，创建必要的化学计量学模型，将光谱特征与反应堆系数关联起来。

Bioreactors are broadly used in a wide variety of process, such as; foods and food ingredients, chemicals and pharmaceutical compounds. These bioreactors are monitored using a wide range of specific analytical techniques which often requires sampling, or they are just specific to a single parameter. This is a lengthy and time-consuming procedure to analyse the required factors to optimise the process. In some cases, the use of hazardous reagents is necessary to perform the analysis.The market is interested in on-line, simple to operate, sampling free, automatic analytical techniques, to monitor the performance of the process within the reactor in real time. Being able to use two laser wavelengths for Raman spectroscopy will allow easy and efficient tailoring of the chemometric modelling used to monitor the reactor on a broader range of reactions than using a single channel setup.The optimisation of the reactor use, associated with the correct dosage of nutrients will lead to higher product yield at lower input cost. ELODIZ, a company specialised on providing analytical solutions based on spectroscopy, is targeting to introduce a sensor based on Raman Spectroscopy for online monitoring of nutrients on bioreactors. This project's focus specifically on the quantification of nitrates and phosphates by a multichannel dual laser Raman device via a single probe. Monitoring the concentration of these key inorganic nutrients with the optimal Raman setup, their concentration can be optimised to maintain an optimum level for the desired product to be successfully formed. ELODIZ will work with Brunel university to create the necessary chemometric models that correlate spectral signature with reactor coefficients.