Urologic Management to Preserve Initial Renal Function Protocol for Young Children with Spina Bifida (UMPIRE)

项目摘要/摘要 脊柱裂是一种主要的先天性脊髓及相关脊椎畸形。大约1645年 在美国，每年出生的婴儿都有这种异常。这个脊髓损伤有许多 对神经系统、整形外科和泌尿系统的有害影响。婴幼儿的泌尿系统评估 脊柱裂从出生就开始了。为了了解最合适的方式更好地理解 婴儿脊柱裂的最佳泌尿外科治疗方案是建立一个多机构试验。 利用“最佳做法”方法。这项试验，泌尿外科治疗保留初始肾 脊柱裂幼儿功能协议“(裁判协议)现已进入第五个年头。这个 该项目在未来5年的患者登记中的目的将是将数据与特定的 临床结果包括肾功能，肾疤痕，上尿路恶化，膀胱动力学， 尿路感染、大小便失禁和手术干预的需要。这些发现将使人们能够更好地定义 需要对最佳实践方案进行更改，以更好地实现最佳泌尿外科 对这些人的管理。

Project summary/Abstract Spina bifida is a major congenital anomaly of the spinal cord and the associated vertebrae. About 1645 infants are born each year in the United States with this anomaly. This spinal cord lesion has numerous deleterious effects on the neurologic, orthopedic and urologic systems. Urological evaluation of infants with spina bifida begins at birth. In order to understand the most appropriate way to better understand the optimal urologic management of infants with spina bifida was to institute a multi-institutional trial utilizing a “best practices” approach. This trial, The Urologic Management to Preserve Initial Renal Function Protocol for young Children with Spina Bifida” (UMPIRE protocol) is now in its fifth year. The purpose of this project in the next 5 years of patient enrollment will be to correlate data with specific clinical outcomes including renal function, renal scarring, upper tract deterioration, bladder dynamics, UTI’s, continence, and need for surgical intervention. These findings will allow one to then better define changes that need to be made to the best practices protocol to better achieve the optimal urologic management of these individuals.