Urologic Management to Preserve Initial Renal Function Protocol for Young Children with Spina Bifida (UMPIRE)

为脊柱裂幼儿保留初始肾功能的泌尿系统治疗方案 (UMPIRE)

• 批准号: 10441115
• 负责人: Robin Bowman
• 金额: $ 2.5万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10441115
• 关键词: Urologic; Management; Preserve; Initial; Renal

Project summary/Abstract Spina bifida is a major congenital anomaly of the spinal cord and the associated vertebrae. About 1645 infants are born each year in the United States with this anomaly. This spinal cord lesion has numerous deleterious effects on the neurologic, orthopedic and urologic systems. Urological evaluation of infants with spina bifida begins at birth. In order to understand the most appropriate way to better understand the optimal urologic management of infants with spina bifida was to institute a multi-institutional trial utilizing a “best practices” approach. This trial, The Urologic Management to Preserve Initial Renal Function Protocol for young Children with Spina Bifida” (UMPIRE protocol) is now in its fifth year. The purpose of this project in the next 5 years of patient enrollment will be to correlate data with specific clinical outcomes including renal function, renal scarring, upper tract deterioration, bladder dynamics, UTI’s, continence, and need for surgical intervention. These findings will allow one to then better define changes that need to be made to the best practices protocol to better achieve the optimal urologic management of these individuals.

项目概要/摘要 脊柱裂是脊髓和相关椎骨的主要先天性异常。约1645 在美国，每年都会有患有这种异常的婴儿出生。这种脊髓病变有很多 对神经系统、骨科和泌尿系统产生有害影响。婴儿泌尿系统评估 脊柱裂从出生时就开始了。为了以最合适的方式更好的理解 脊柱裂婴儿的最佳泌尿外科管理是开展多机构试验 利用“最佳实践”方法。本试验，保留初始肾脏的泌尿科管理 针对患有脊柱裂的幼儿的功能协议”（UMPIRE 协议）现已进入第五个年头。 该项目在未来 5 年的患者入组中的目的是将数据与特定的 临床结果包括肾功能、肾疤痕、上尿路恶化、膀胱动力学、 尿路感染、失禁和手术干预的需要。这些发现将使人们能够更好地定义 需要对最佳实践方案进行更改，以更好地实现最佳泌尿外科效果 对这些人的管理。