Understanding the role of bilevel positive airway pressure (BPAP) in pediatric acute asthma exacerbations: A prospective, randomized, double blind, controlled trial.
了解双水平气道正压通气 (BPAP) 在小儿哮喘急性加重中的作用:一项前瞻性、随机、双盲对照试验。
基本信息
- 批准号:10448153
- 负责人:
- 金额:$ 47.82万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-20 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:17 year oldAccident and Emergency departmentAcuteAdmission activityAdverse eventAftercareAgonistAlveolarAlveolusAsthmaBlindedChildChild MortalityChildhoodChildhood AsthmaClinicalClinical TrialsConsumptionControl GroupsCritical CareDataDiseaseDisease MarkerDistalDouble-Blind MethodEducationForced expiratory volume functionGoalsGuidelinesHealthcare SystemsHospitalizationHourHypotensionInhalationInterventionLengthMeasurementMeasuresMechanical ventilationMonitorMucous body substanceNational Heart, Lung, and Blood InstituteNebulizerObstructionOutcome MeasureOxygenPatientsPediatric HospitalsPediatric Intensive Care UnitsPhysiologicalPrevention programProcessPublic HealthPulmonary Function Test/Forced Expiratory Volume 1RandomizedResourcesRespiratory FailureRespiratory physiologyRoleSecondary toSeverity of illnessSkinStentsTachycardiaTimeTime ManagementTremorUnited StatesUnited States National Institutes of HealthVomitingWork of Breathingacute careasthma exacerbationclinical practicecostimprovedpatient orientedpediatric emergencypediatric patientspositive airway pressurepressurepreventprimary outcomeprospectiverecruitrespiratorysecondary outcomeside effectventilation
项目摘要
Asthma remains one of the top three causes of hospitalization in children in the United States. Interventions that
rapidly reverse bronchial obstruction and decrease the need for continuous beta-agonist therapy will not only
directly benefit the patient, but also decrease the consumption of acute care resources. Bilevel positive airway
pressure (BPAP) is a form of non-invasive positive pressure ventilation that may stent open airways, improve
mucous clearance, recruit alveoli, and increase responsiveness to continuous beta-agonist therapy in the small
distal airways. However, BPAP is not currently part of the NIH guidelines for the management of pediatric acute
asthma secondary to the lack of quality pediatric clinical trials. The goal of this prospective, randomized, double
blind, controlled trial is to determine if early initiation of BPAP is effective and safe in pediatric patients presenting
to a pediatric emergency department with acute moderate to severe asthma exacerbations who fail first line
therapy.
哮喘仍然是美国儿童住院的三大原因之一。的干预措施
快速逆转支气管阻塞并减少对持续β受体激动剂治疗的需求不仅可以
不仅直接使患者受益,而且还减少了急性护理资源的消耗。双水平气道正压
正压通气(BPAP)是一种无创正压通气形式,其可以支撑开放的气道,改善气道压力,
粘液清除,招募肺泡,并增加对持续β受体激动剂治疗的反应性,
远端气道然而,BPAP目前不是NIH儿科急性呼吸道感染管理指南的一部分。
哮喘继发于缺乏高质量的儿科临床试验。这项前瞻性、随机、双
一项盲法对照试验旨在确定早期开始BPAP治疗儿科患者是否有效和安全,
急性中度至重度哮喘急性发作一线治疗失败的儿科急诊科
疗法
项目成果
期刊论文数量(0)
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Patrick Thomas Wilson其他文献
Patrick Thomas Wilson的其他文献
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{{ truncateString('Patrick Thomas Wilson', 18)}}的其他基金
Understanding the role of bilevel positive airway pressure (BPAP) in pediatric acute asthma exacerbations: A prospective, randomized, double blind, controlled trial.
了解双水平气道正压通气 (BPAP) 在小儿哮喘急性加重中的作用:一项前瞻性、随机、双盲对照试验。
- 批准号:
10720503 - 财政年份:2022
- 资助金额:
$ 47.82万 - 项目类别: