Center for Skeletal Research (Overall Application)

骨骼研究中心（整体应用）

• 批准号: 10451719
• 负责人: Marie Demay
• 金额: $ 84.17万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-19 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10451719
• 关键词: Advisory Committees; Award; Biological Assay; Biology; Boston; Cell Separation; Cells; Clinical Investigator; Collaborations; Communication; Communities; Complement; Core Facility; Country; Custom; Data; Dental Schools; Development; Diagnosis; Diagnostic tests; Discipline; Disease; Educational workshop; Effectiveness; Endocrine; Faculty; Feedback; Fostering; Funding; General Hospitals; Goals; Grant; Histologic; Histology; Human; Image; Institution; Laboratories; Laboratory Research; Lead; Maine; Massachusetts; Medicine; Mentors; Methodology; Methods; Mus; New England; Osteoporosis; Phenotype; Postdoctoral Fellow; Protocols documentation; Radiology Specialty; Rare Diseases; Research; Research Personnel; Resources; Sampling; Science; Scientist; Sequence Analysis; Series; Services; Signal Transduction; Site; Suggestion; System; Techniques; Time; Travel; United States National Institutes of Health; Universities; Update; Work; base; bone; bone cell; bone imaging; calcium metabolism; environmental enrichment for laboratory animals; experience; innovation; medical schools; meetings; member; microCT; novel; novel diagnostics; novel therapeutics; phosphorus metabolism; posters; programs; single-cell RNA sequencing; skeletal; skeletal disorder; success; symposium; tool; transcriptome sequencing; web site

The overall goal of the Center for Skeletal Research is to foster interdisciplinary and collaborative work that leads to a deeper understanding of skeletal biology and disease. The Center will build upon and expand a community of bone scientists in the Endocrine Unit and other Units at the Massachusetts General Hospital, other Harvard institutions, and Boston University and other institutions in Boston and the broader New England region. These scientists are diverse, including clinical investigators and laboratory investigators using a broad array of approaches from multiple disciplines. The mechanisms that the Center will use to accomplish its goal include Core Facilities, a Pilot and Feasibility Grant Program, and an enrichment program. The Cores will include an Administrative Core, a Skeletal Phenotyping Core and a Bone Cell Analysis Core. These Cores will emphasize the development of new techniques that can drive the science of Center investigators, as well as the provision of expert and efficient service. The services include histology, microCT imaging, human and mouse bone cell isolation, bulk and single cell RNA sequencing of bone, and bone signaling assays. The Administrative Core will direct the research cores, a Pilot and Feasibility Program, and also an enrichment program. The enrichment program will include a monthly seminar series featuring talks by junior investigators of the Center, a methods workshop series, a Pilot and Feasibility Program, an Innovation Awards program (travel awards and mini-grant program), and a yearly Symposium/poster session. The goal of the Pilot and Feasibility Grant Program will be to allow young investigators to develop sufficient data to obtain their own grants; in that context, a vigorous mentoring program will complement the funding. The seminar series will foster collaboration and communication among Center scientists. Young investigators will present current data in some sessions, while others will bring in distinguished bone scientists from outside of Boston to enrich the environment. This series will also include presentations by Core Directors that explain the techniques used in the Cores and will provide a forum for feedback by Center investigators that will include suggestions for novel Core services. An Administrative Core will assure effective functioning of these activities through regular meetings of Core Directors that, four times a year, will also involve meeting with an Advisory Committee made up of senior investigators within the Center, as well as investigators from elsewhere with relevant experience leading similar programs. The Center will be committed to sharing its innovations with the broader community of bone scientists across the country.

该中心的总体目标是促进跨学科和协作工作， 从而更深入地了解骨骼生物学和疾病。该中心将建立并扩大一个 马萨诸塞州总医院内分泌科和其他科室的骨科学家社区， 其他哈佛大学、波士顿大学以及波士顿和更广泛的新英格兰的其他机构 地区这些科学家是多样化的，包括临床研究人员和实验室研究人员，使用广泛的 一系列来自多个学科的方法。该中心将用来实现其目标的机制 包括核心设施、试点和可行性赠款方案以及浓缩方案。核心会 包括一个管理核心、一个Skeletal表型核心和一个骨细胞分析核心。这些核心将 强调新技术的发展，可以推动中心研究人员的科学，以及 提供专业和高效率服务。这些服务包括组织学、显微CT成像、人类和 小鼠骨细胞分离、骨的整体和单细胞RNA测序以及骨信号传导测定。的 行政核心将指导研究核心，一个试点和可行性计划，也是一个丰富的 程序.充实计划将包括每月一次的研讨会系列，由初级调查人员进行会谈 该中心，方法研讨会系列，试点和可行性计划，创新奖计划 （旅行奖励和小额赠款计划），以及每年的研讨会/海报会议。试点的目标和 可行性资助计划将允许年轻的研究人员开发足够的数据，以获得他们自己的 赠款;在这方面，一个有力的指导方案将补充资金。系列研讨会将 促进中心科学家之间的合作和交流。年轻的研究人员将展示当前的数据 在一些会议上，而其他人将带来杰出的骨骼科学家从波士顿以外，以丰富 环境本系列还将包括核心董事的演示文稿，解释 核心，并将提供一个论坛，由中心的调查人员，将包括建议的小说反馈 核心服务。一个行政核心将确保这些活动的有效运作， 核心董事会议，每年四次，还将包括与咨询委员会的会议， 该中心的高级研究人员，以及来自其他地方的具有相关经验的研究人员 领导类似的项目。该中心将致力于与更广泛的社区分享其创新成果 全国各地的骨骼科学家。