Administrative Core

行政核心

• 批准号: 10450038
• 负责人: Paul Wesley Noble
• 金额: $ 12.52万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10450038
• 关键词: Adherence; Allografting; Animal Model; Chronic; Disease; Disease Progression; Epithelial; Functional disorder; Goals; Human; Lung; Mesenchymal; Physicians; Productivity; Pulmonary Fibrosis; Regulation; Research Personnel; Sampling; Scientist; United States National Institutes of Health; Work; combat; idiopathic pulmonary fibrosis; improved; lung allograft; new therapeutic target; programs; skills

PROJECT SUMMARY The purpose of the Program is to bring together a team of investigators to focus on the pathobiology of two important disease states, Chronic Lung Allograft Dysfunction and idiopathic pulmonary fibrosis using both state-of-the-art animal modeling and human samples. The goals of this Program are to improve our understanding of the mechanisms that contribute to disease progression and identity novel therapeutic targets to combat lung fibrosis whether it occurs in the airway or in the interstitium of the lung. The Program brings together a team of scientists and physician scientists with complementary skills to work as a unit on these important problems. In order to coordinate these efforts, we propose an Administrative Core to facilitate interactions and adherence to NIH regulations regarding management of PO1 proposals. We propose the following Specific Aims:  Coordinate and facilitate administration of the Program between Project Leaders and Core Leaders.  Coordinate and facilitate administration of the Program between investigators, internal and external advisors and an enrichment program organized to maximize scientific productivity.

项目摘要 该计划的目的是汇集一个研究小组，专注于两种疾病的病理生物学。 重要疾病状态、慢性同种异体肺功能障碍和特发性肺纤维化， 最先进的动物模型和人体样本该计划的目标是提高我们的 了解导致疾病进展的机制并确定新的治疗靶点 以对抗肺纤维化，无论它发生在气道还是肺的胸膜。该方案带来 一个由科学家和具有互补技能的医生科学家组成的团队， 重要的问题。为了协调这些努力，我们建议设立一个行政核心， 互动和遵守NIH关于PO1提案管理的规定。我们建议 具体目标： 协调和促进项目领导和核心领导之间的计划管理。 协调和促进内部和外部研究人员之间的计划管理 顾问和丰富的计划组织，以最大限度地提高科学生产力。