Surgical Research Training in Gastrointestinal Diseases

项目摘要/摘要 UTMB外科T32研究培训计划提供最先进的跨学科 对胃肠道疾病感兴趣的外科住院医师的研究培训经验， 胰腺和肝脏。我们的中心目标是培养我们的同事成为高效、独立的医生- 科学家和未来外科学术研究的领导者。通过这一具有竞争力的续订申请，我们 请求继续提供支持，每年培训三名博士后研究员。我们高度结构化的学位- 授予课程的目的是为研究员提供必要的全面基础培训 与有效性相关的科学知识、方法、技术技能和伦理考虑 基础和转化性生物医学实验室研究实践或比较有效性和 与胃肠道疾病相关的以患者为中心的结局研究。自成立以来，该项目已培训了32名 博士后研究员。在完成临床培训的人中，52%的人目前处于学术阶段 手术，其中一半已经成功地争取到了NIH的资金。学员得到了以下人员的指导 教师致力于科学知识的前沿，并利用最新的技术和 可用于胃肠道疾病研究领域的实验方法。最初专注于内分泌学 肠肽激素和大型动物模型，今天我们的项目教员研究GI微生物群和病理- 基因生物学，胃肠道免疫学，炎症与组织纤维化，胃肠道组织正常生长机制， 损伤修复、致癌、流行病学和临床结果研究。他们使用转基因的 啮齿动物模型、多种细胞类型培养系统、最新组学技术和生物信息学 高分辨率分子成像，先进的分子和细胞分离技术， 先进的基因编辑和表达方法、重组DNA、微RNA和报告基因检测， 适应性细胞转移程序、表观遗传学和最先进的分离、分析和培养方法 特定于组织和疾病的微生物群。我们高度协作和高效的教师导师(有550名 过去5年出版的出版物，以及目前超过2300万美元的赠款资金)代表了UTMB的9个部门 (5个临床/4个基础科学)。这种多学科的培训环境培养了我们的生产力 院士，共发表科学论文85篇(平均6篇/院士；第一作者发表2.8篇- 在过去的10年里)。我们良好的记录证明了我们在招聘少数族裔方面取得了成功 和女性加入我们的培训计划。在过去的10年里，60%是女性，40%也被认为是 未被充分代表的少数群体。总而言之，我们已经建立了一个稳健的成就记录，通过准备 我们的研究员将成为高效、独立的内科科学家和未来外科学术领域的领导者 研究。在NIH和NIDDK的进一步支持下，我们将继续我们丰富的成功历史， 不断增长的需求，需要训练有素的内科医生和科学家进入生物医学大军。

PROJECT SUMMARY/ABSTRACT The UTMB Department of Surgery T32 research training program provides state-of-the-art interdisciplinary research training experiences for surgical residents interested in diseases of the gastrointestinal (GI) tract, pancreas, and liver. Our central goal is to prepare our fellows to become productive, independent physician- scientists and future leaders in academic surgical research. With this competitive renewal application, we are requesting continued support to train three postdoctoral fellows per year. Our highly structured, degree- granting curricula are designed to provide fellows with comprehensive foundational training in essential scientific knowledge, methodologies, technical skills, and ethical considerations pertinent to the effective practice of either basic and translational biomedical laboratory research or comparative effectiveness and patient-centered outcomes research related to GI diseases. Since its inception, the program has trained 32 postdoctoral fellows. Of those who have completed their clinical training, 52% are currently in academic surgery, and half of those have successfully competed for NIH funding. Trainees have been mentored by faculty working at the cutting edge of scientific knowledge and utilized the most up-to-date technologies and experimental approaches available to the field of GI disease research. Initially focused on the endocrinology of gut peptide hormones and large animal models, today our program faculty study the GI microbiome and patho- genic organisms, GI immunology, inflammation and tissue fibrosis, mechanisms of GI tissue normal growth, injury repair, and carcinogenesis, epidemiology and clinical outcomes research. They use genetically modified rodent models, multiple cell-type culture systems, the latest omics technologies and bioinformatics approaches, high resolution molecular imaging, advanced molecular and cellular separation technologies, sophisticated gene editing and expression methods, recombinant DNA, microRNA and reporter gene assays, adaptive cellular transfer procedures, epigenetics, and state-of-the-art methods to isolate, analyze and culture tissue- and disease-specific microbiomes. Our highly collaborative and productive faculty mentors (with 550 publications in the past 5 years, and over $23 million in current grant funding) represent 9 UTMB departments (5 clinical / 4 basic science). This multidisciplinary training environment has fostered the productivity of our fellows, who have published a total of 85 scientific papers (average of 6 papers/fellow; 2.8 first author publica- tions) in the past 10 years. Our strong track record stands as evidence for our success in recruiting minorities and women into our training program. In the past 10 years, 60% have been women and 40% also identified as an underrepresented minority. In summary, we have established a robust record of achievement by preparing our fellows to become productive, independent physician-scientists and future leaders in academic surgical research. With further support from the NIH and NIDDK, we will continue our rich history of success and meet the ever-growing need to prepare well-trained physician-scientists to enter the biomedical workforce.