A mobile phone short message service intervention to increase retention in HIV care among HIV-positive men who have sex with men in Peru (WelTel Peru)

一项手机短信服务干预措施，旨在提高秘鲁男男性行为艾滋病毒阳性男性对艾滋病毒护理的保留率 (WelTel Peru)

• 批准号: 10456978
• 负责人: LUIS ALBERTO MENACHO ALVIRIO
• 金额: $ 14.44万
• 依托单位: UNIVERSIDAD PERUANA CAYETANO HEREDIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-17 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10456978
• 关键词: AIDS prevention; Adherence; Affect; Appointment; Area; Award; Awareness; Car Phone; Caring; Cellular Phone; Clinic; Clinical; Cohort Studies; Communication; Computer software; Continuity of Patient Care; Country; Data; Diagnosis; Effectiveness of Interventions; Enrollment; Epidemic; Epidemiologic Methods; Evaluation; Fostering; Funding; Funding Mechanisms; Gays; General Population; Goals; Government; Grant; HIV; HIV Infections; HIV Seropositivity; HIV prevention trial; Health; Health Personnel; Health Policy; Hospital Referrals; Hospitals; Human immunodeficiency virus test; Incidence; Infection; Institution; International; Intervention; Intuition; K-Series Research Career Programs; Knowledge; Latin America; Link; Manuscripts; Mentors; Mentorship; Methods; Monitor; Morbidity - disease rate; Online Systems; Outcome; Participant; Patient Self-Report; Patients; Persons; Peru; Peruvian; Population Group; Prevalence; Privatization; Provider; Qualitative Research; Quality of Care; Randomized; Randomized Controlled Trials; Reporting; Research; Research Personnel; Research Proposals; Research Training; Resource-limited setting; Risk; Role; Sexually Transmitted Diseases; Site; Statistical Methods; System; Technology; Telephone; Testing; Text Messaging; Time; Training; Training Support; Treatment Efficacy; Viral; Visit; World Health Organization; Writing; antiretroviral therapy; arm; base; career; cost effective; design; effective intervention; effectiveness evaluation; experience; global health; implementation science; improved; interest; mHealth; men; men who have sex with men; mobile computing; mortality; mortality risk; multi-site trial; multidisciplinary; novel; recruit; responsible research conduct; service intervention; skills; standard care; standard of care; tool; transmission process; treatment arm; two way texting; viral resistance; young men who have sex with men

Summary Retention in HIV care is associated with longer survival, viral suppression, and lower HIV transmission. HIV disproportionally affects men who have sex with men (MSM). In Peru, the HIV epidemic is concentrated among them (prevalence 12.2%), while only 0.4% of the general population is HIV+. Worryingly, MSM with HIV are less likely to stay engaged in care! than other population groups. Studies with MSM have reported efficacy of text-message (SMS) reminders for retesting of HIV and other sexually transmitted infections. However, more trials are needed with them in order to assess the use of SMS for increasing retention in HIV care in resource- limited settings, such as in Latin America. Two-way text messaging can provide an increased level of real-time support to patients. WelTel was the first randomized controlled trial using an interactive two-way text messaging approach that reported a significant increase in self-reported adherence and viral suppression. The hypothesis for this study is that an upgraded version of WelTel to deliver an interactive two-way SMS-based intervention will increase retention in care among HIV+ MSM in Peru. This career development award seeks: 1) to develop an SMS-based intervention to be delivered through the WelTel system to increase retention in HIV care among HIV-positive MSM at a government-based hospital in Peru; and 2) to determine the efficacy of the intervention for increasing retention in HIV care when compared with standard-of-care. I will recruit 208 HIV+ MSM and randomize them (1:1) to an intervention (receives the SMS-based intervention) and control (standard of care) group. I will follow them up throughout the duration of the twelve months course. The main outcome will be retention in HIV care within one year after enrollment. Results will be used to design a multi- site trial to assess the effectiveness of the intervention in improving retention in HIV care among HIV+ Peruvian MSM that will be submitted for R01 funding. A multi-disciplinary mentoring team will support me with expertise in areas related to my career plan: HIV prevention trials (Dr. Duerr), mobile health (Dr. Blas and Dr. Lester), HIV research (Dr. Gonzales), implementation science (Dr. Zunt), qualitative research (Dr. Galea), quantitative methods (Dr. Carcamo), and evaluation of interventions (Dr. Garcia). With them, I have designed a training plan to fill the gaps in knowledge and skills I need to succeed in my goals. I will obtain additional formal training in qualitative research and implementation science, and! statistical and epidemiological methods. I will also acquire skills in grant/manuscript writing and I will pursue continuous training in responsible conduct of research. This mentored research training support will enable me to achieve my goal of becoming a leading global health researcher at Universidad Peruana Cayetano Heredia, actively collaborating with top international institutions and fostering health policies with rigorous evidence.

总结