Bio-Behavioral Core

生物行为核心项目总结 生物行为核心代表了UCSF湾区中心的创新方案， 艾滋病研究。在我们与研究、临床、政策和社区的战略规划过程中， 我们确定了CFAR需要扩展的三种关键方式，以满足 研究人员和响应NIH艾滋病毒为重点的研究优先事项。这三个扩展在 艾滋病毒预防，物质使用研究和评估行为生物标志物，如客观 依从性和物质使用的指标。首先，我们现在支持一个多样化的人群在PrEP住房 在我们的旧金山弗朗西斯科公共卫生部（SFDPH）附属机构，该机构为一系列 PrEP队列（PrEP Cohort）PrEP队列收集参与者的调查数据和样本， PrEP（口服和注射，如有），可灵活用于早期研究者的附加研究 （ESI）。第二，我们会就测量和干预方法的整合提供专家咨询 应对艾滋病毒预防和治疗中物质使用的重大挑战（物质使用 研究计划）。利用UCSF和我们的附属机构的专业知识，这个新计划将解决 艾滋病毒预防和护理方面的最大挑战，努力优化成果。第三，生物行为核心 支持行为生物标志物的开发，实施和分析，特别是客观的 艾滋病毒研究中的依从性和物质使用指标（行为生物标志物计划）。这个新 该计划将提供这些指标的测定和解释，以支持PrEP队列和物质 使用研究计划。 新的生物行为核心将与其他核心和工作/利益集团密切合作，以确保 有效利用CFAR资源，以实现中心的总体目标和贯穿各领域的卫生优先事项 公平/社区参与、国际艾滋病毒研究和培训/职业发展。PrEP队列 使用与临床核心中的SCOPE队列相同的数据元素和基础设施;生物行为 核心组件将全部支持来自代表性不足的少数族裔（URM）背景的ESI和调查人员 在发展核心;这个核心将与新的住房和交叉科学密切合作 健康结构决定因素工作组。总的来说，这个新的核心将提供额外的 通过解决以前CFAR调查人员应对新出现的挑战的能力差距， 艾滋病毒流行病，提供了一个平台，为环境服务机构建立研究计划，并使调查人员进行 社区参与的工作，旨在减少艾滋病毒和相关的健康差距。

BIO-BEHAVIORAL CORE PROJECT SUMMARY The Bio-Behavioral Core represents an innovative programmatic approach for the UCSF-Bay Area Center for AIDS Research (CFAR). During our strategic planning process with research, clinical, policy, and community stakeholders, we identified three critical ways in which our CFAR needed to expand to meet the needs of investigators and be responsive to NIH HIV-focused research priorities. These three expansions are in the areas of HIV prevention, substance use research, and assessing biomarkers of behavior, such as objective metrics for adherence and substance use. First, we now support a diverse cohort of persons on PrEP housed at our San Francisco Department of Public Health (SFDPH) affiliate, which provides infrastructure for a range of research inquiries (PrEP Cohort). The PrEP cohort collects survey data and specimens on participants on PrEP (oral and injectable when available) and is nimble for add-on studies from early-stage investigators (ESIs). Second, we will provide expert consultation on integrating measurement and intervention approaches that are responsive to significant challenges of substance use in HIV prevention and treatment (Substance Use Research Program). Harnessing expertise at UCSF and our affiliates, this new Program will address one of the greatest challenges in HIV prevention and care to try to optimize outcomes. Third, the Bio-Behavioral Core supports the development, implementation, and analysis of biomarkers of behavior, specifically objective metrics of adherence and substance use in HIV research (Biomarkers of Behavior Program). This new program will provide assays and interpretation of these metrics to support the PrEP cohort and the Substance Use Research Program. The new Bio-Behavioral Core will work closely with the other Cores and working/interest groups to ensure efficient use of CFAR resources to address overall Center aims and crosscutting priorities of health equity/community engagement, international HIV research, and training/career development. The PrEP cohort uses the same data elements and infrastructure as the SCOPE cohort in the Clinical Core; the Bio-Behavioral Core components will all support ESIs and investigators from underrepresented minority (URM) backgrounds in the Developmental Core; and this Core will work closely with the new Housing and Intersectionality Scientific Working Groups (SWGs) on structural determinants of health. Collectively, this new Core will provide added value by addressing previous gaps in the capacity of CFAR investigators to meet emerging challenges of the HIV epidemic, provide a platform for ESIs to build programs of research, and enable investigators to conduct community-engaged work aimed at mitigating HIV and related health disparities.