STUDY CLOSE-OUT FOR THE RANDOMIZED TRIAL TO EVALUATE THE VIROLOGIC RESPONSE AND PHARMACOKINETICS OF TWO DIFFERENT POTENT REGIMENS IN HIV INFECTED WOMEN

执行并完成方案之外的研究，该方案是比较这两个抗逆转录病毒(ARV)类别的代表在延迟接受治疗的艾滋病毒感染孕妇中的安全性、耐受性、病毒学和药理学反应。在怀孕后期提出护理的艾滋病毒感染孕妇需要快速反应和有效的抗逆转录病毒疗法，以最大限度地减少艾滋病毒传播给新生儿的风险。没有数据比较非核苷酸逆转录酶抑制剂(NNRTI)和整合酶抑制剂(IIs)对孕妇的影响。完成该议定书的收尾活动将提供最终的数据集/信息。研究收尾活动包括完成手稿、完成数据分析并将数据和样本存储到NICHD DASH储存库。

To perform and complete the study close out of the protocol, which is to compare the safety, tolerance, virologic and pharmacologic responses of representatives of these two antiretroviral (ARV) classes in HIV-infected pregnant women presenting late for care. HIV-infected pregnant women presenting for care late in pregnancy need a rapid response and effective ARV therapy to minimize the risk of HIV transmission to their newborn. No data are available comparing the effects of non-nucleotide reverse transcriptase inhibitors (NNRTIs) and Integrase Inhibitors (IIs) in pregnant women. Completion of the close out activities of this protocol will provide the final dataset/information. The study close-out activities include the completion of the manuscript, complete data analysis and store data and samples to the NICHD DASH repository.