ERC Einstein Rockefeller CUNY Center for AIDS Research

项目摘要 ERC-CFAR：医疗核心 Einstein-Rockefeller-CUNY CFAR（ERC-CFAR）开发核心将努力提供广泛的 支持培养和推进未来艾滋病毒/艾滋病研究人员的艾滋病毒/艾滋病研究事业。我们 该更新申请的协调战略将通过三个具体目标实施， 早期研究者（Early Stage Investigators，ESIs）在目标1中，我们将采用多方面的指导过程， 结合为每个ESI和多个论坛开发的个性化指导计划，使ESI能够 向ERC-CFAR社区介绍他们的艾滋病毒/艾滋病研究进展，以获得反馈并开发新的 合作。在目标2中，我们将为环境服务机构提供在同行评审的环境风险控制-CFAR中竞争的机会 催化试点赠款和小额赠款计划或NIH CFAR行政补充机会。目标3 包括加强跨机构和机构内合作以及科学交流的双重目标。 将通过以下方式加强合作：（i）招募非艾滋病研究人员与艾滋病毒/艾滋病研究中心的调查人员合作 并通过消除成功的障碍-通过提供高达1万美元的小额赠款和获得艾滋病毒队列; (ii)组织两年一度的虚拟K俱乐部，参加者包括爱因斯坦、洛克菲勒和纽约市立大学的ESI， 包括成功的环境影响评估机构和应急救援中心-常规武器反应堆发展和运行核心的报告 领导人关于所有可用的CFAR服务，可以帮助ESI在他们的研究项目和计划的赠款 （iii）每两年举办一次纽约全市范围的研究专题讨论会，由纽约市所有艾滋病毒/艾滋病感染者参加 研究人员将选择来自纽约市不同主要机构的个人来展示他们的切割 边缘研究我们将通过（i）每两周一次的 跨机构ERC-CFAR虚拟研究研讨会和双周临床艾滋病中心/ERC-CFAR Grand （ii）ERC-CFAR特邀演讲者研讨会;（iii）每月病毒中心会议，包括13次Einstein会议 病毒学家，其中包括9名专注于HIV，HSV或HCV研究的教职员工。这提供 所有ERC-CFAR ESIs都可以通过一个特殊的一站式商店了解爱因斯坦正在进行的最新病毒学研究。 紧急救济协调员-《非洲人道主义法》提供的这些高度协调和积极主动的辅导服务产生了令人印象深刻的影响 发展核心在过去4年的资助是由我们的指导ESI的成就证明 其中包括2 050万美元的外部赠款和250份出版物。ERC-CFAR的高度影响 发展核心的催化试点赠款计划，该计划已授予14个试点赠款，以环境影响评价迄今（0.46 从所有三个参与机构获得的资金（100万美元）反映在他们已经获得了约810万美元的资金这一事实上。 2000万赠款（投资回报率为17.6），发表论文70多篇。

PROJECT SUMMARY ERC-CFAR: DEVELOPMENTAL CORE The Einstein-Rockefeller-CUNY CFAR (ERC-CFAR) Developmental Core will strive to provide wide-ranging support to nurture and advance the HIV/AIDS research careers of tomorrow’s HIV/AIDS researchers. Our coordinated strategy for this renewal application will be implemented via three specific aims that are centered around early stage investigators (ESIs). In Aim 1, we will employ a multi-faceted mentoring process, which combines individually tailored mentoring plans developed for each ESI and multiple forums to enable ESIs to present their HIV/AIDS research progress to the ERC-CFAR community to garner feedback and develop new collaborations. In Aim 2, we will provide ESIs with opportunities to compete in the peer-reviewed ERC-CFAR catalytic pilot grants and microgrants programs or NIH CFAR administrative supplements opportunities. Aim 3 includes dual goals of enhancing trans- and intra-institutional collaborations and scientific communication. Collaborations will be increased by: (i) recruiting non-AIDS researchers to collaborate with CFAR investigators and by removing obstacles to succeed – both by providing microgrants up to $10K and access to HIV cohorts; (ii) organizing bi-annual virtual K-clubs that are attended by ESIs from Einstein, Rockefeller and CUNY and that include both presentations by successful ESIs and by the ERC-CFAR Developmental and Operational Core leaders about all available CFAR services that can assist ESIs in their research projects and planned grant submissions; and (iii) organizing bi-annual New York City-wide research symposia attended by all NYC HIV/AIDS researchers where individuals from the different major NYC institutions will be selected to present their cutting edge research. We will enhance scientific communication among the investigators of ERC-CFAR via (i) bi-weekly Trans-institutional ERC-CFAR virtual research seminars and biweekly Clinical AIDS Center/ERC-CFAR Grand Rounds; (ii) ERC-CFAR Invited Speaker Seminars; (iii) Monthly Virus Hub meetings consisting of 13 Einstein virologists, which includes 9 faculty members that are focused on research on HIV, HSV or HCV. This provides a special one-stop-shop for all ERC-CFAR ESIs to learn about the latest virological research going on at Einstein. The impressive impact of these highly coordinated and proactive mentoring services by the ERC-CFAR Developmental Core over the past 4 years of funding is demonstrated by accomplishments of our mentored ESIs that include $20.5 million of external grants and 250 publications. The high impact of the ERC-CFAR Developmental Core’s catalytic pilot grant program, which has awarded 14 pilot grants to ESIs so far (0.46 million) from all three participant institutions, is reflected in the fact that they have already garnered up to ~$8.1 million in NIH grants (a return on investment of 17.6) and that they have published over 70 papers.