Vaccine Response and Immunotherapeutics SWG

疫苗反应和免疫治疗 SWG

• 批准号: 10458365
• 负责人: Anna Palmer Durbin
• 金额: $ 6.08万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-02 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10458365
• 关键词: 2019-nCoV; Acquired Immunodeficiency Syndrome; Address; Adult; Affect; Applications Grants; Area; Attention; Award; COVID-19; COVID-19 pandemic; COVID-19 vaccine; Childhood; Clinic; Clinical; Clinical Research; Collaborations; Communities; Consequences of HIV; Development; Disease; Education; Effectiveness; Evaluation; Extramural Activities; Faculty; Fertilization; Fostering; Goals; Grant; Growth; HIV; HIV vaccine; Hepatitis B; Herpes zoster disease; Immune response; Immunology; Immunotherapeutic agent; Infection; Interdisciplinary Study; International; Laboratories; Mentors; Methods; Outcome; Persons; Positioning Attribute; Preparation; Preventive vaccine; Public Health; Recommendation; Research; Research Personnel; Research Project Grants; Research Proposals; Resources; Schedule; Science; Seasons; Sexually Transmitted Diseases; Speed; Systems Biology; Tuberculosis; United States National Institutes of Health; Vaccination; Vaccine Clinical Trial; Vaccines; Viral hepatitis; Work; career; cohesion; cohort; coronavirus disease; immunogenicity; implementation science; implementation strategy; innovation; interest; meetings; protocol development; respiratory pathogen; science education; success; synergism; therapeutic vaccine; tumor immunology; uptake; vaccine access; vaccine development; vaccine evaluation; vaccine immunogenicity; vaccine response; vaccine trial; vaccinology; working group

The Vaccine Response and Immunotherapeutics (VRI) Scientific Working Group was added to the CFAR in 2021 to foster research related to vaccines and other immunotherapeutics for people living with HIV (PLWH). The SARS-CoV-2 pandemic has demonstrated the enormous public health impact of vaccination. As much of the scientific community pivoted to studying SARS-CoV-2 and vaccine development proceeded with unprecedented speed, HIV researchers at JHU recognized the importance of inclusion of PLWH in vaccine studies, as well as the potential implications of COVID-19 vaccinology to other vaccines, including HIV preventive and therapeutic vaccines. The immunosuppressive consequences of HIV on the effectiveness and durability of vaccine protection is not well characterized and is an important area of research. In addition to COVID vaccines, clinical research evaluating the durability and cellular immune responses to childhood and other adult vaccines is critical to determining if current vaccine schedules and recommendations are appropriate for PLWH. This SWG will focus on HIV and non-HIV vaccines and immunotherapeutics for PLWH to promote vaccine science education, foster research interest in vaccines and immunotherapeutics among early- and mid-level faculty, and coordinate with other SWGs to achieve these goals.

新增疫苗反应和免疫治疗（VRI）科学工作组 2021年CFAR将促进与疫苗和其他免疫治疗药物相关的研究， 艾滋病毒感染者（PLWH）。SARS-CoV-2大流行表明， 疫苗接种对公众健康的影响。随着科学界的大部分人转向研究 SARS-CoV-2和疫苗开发以前所未有的速度进行，HIV研究人员 在JHU认识到在疫苗研究中纳入PLWH的重要性，以及 COVID-19疫苗学对其他疫苗的潜在影响，包括艾滋病毒预防和 治疗性疫苗艾滋病毒对免疫抑制效果的影响， 疫苗保护的持久性还没有得到很好的表征，这是一个重要的研究领域。在 除了COVID疫苗，临床研究评估的持久性和细胞免疫 对儿童和其他成人疫苗的反应对于确定目前的疫苗是否 时间表和建议适用于PLWH。该工作组将重点关注艾滋病毒问题， 为艾滋病毒感染者提供非艾滋病毒疫苗和免疫治疗药物，以促进疫苗科学教育， 培养早期和中级教师对疫苗和免疫治疗的研究兴趣， 并与其他SWG协调以实现这些目标。