Data Core

建议的U54应用程序将研究重复性头部撞击(RHI)和创伤性脑损伤之间的关联 损伤(TBI)合并阿尔茨海默病(AD)和相关痴呆(ADRD)、慢性创伤性脑病 (CTE)和其他神经病理学，以及由此产生的临床症状。数据的主要任务是 协调核心(DCC)是在数据管理和统计的所有阶段提供领导和专业知识 分析，从项目基础设施的开发到成果的公布。此协作协助 包括数据共享、分析计划的制定、数据库设计、数据收集实施 和质量控制程序、技术支持、分析数据集的创建、统计分析以及 手稿准备工作。我们的总体目标是在整个研究范围内提供程序一致性和效率 系统，最终产生最高质量的数据和分析，供研究人员和附属机构使用。 DCC将协调来自8个新型脑库的数据：波士顿大学(BU)的6个：VA-BU-CLF或UNIT， 神经创伤联盟(CENC)、阿尔茨海默病中心(BUADC)、退伍军人管理局(VA)的慢性影响 侧索硬化症(ALS)、退伍军人创伤后应激障碍(PTSD)和弗雷明翰心脏研究(FHS)脑 BANKS和ISMMS的2人：TBI的后期影响(LETBI)和AD研究中心(ADRC)。的主要目标 数据中心将维护一个综合的、用户友好的数据管理系统，并执行以下程序 确保最高质量的数据、安全性和完整性；在 为所有得到支助的项目调查员提供方法论设计和统计分析；并提供系统和 支持所有研究站点和合作者之间的资源共享。为了实现这些目标，我们的目标是1) 使用集成的、用户友好的系统提供集中式数据基础设施，以共享信息、数据、 和分析工具。2)使用集成的、用户友好的共享系统提供集中的数据管理 信息、数据和分析工具；3)传播综合数据集，以加速 研究目标；4)为所有研究项目提供高水平的生物统计学专业知识。

The proposed U54 application will examine the association of repetitive head impacts (RHI) and traumatic brain injury (TBI) with Alzheimer's disease (AD) and related dementias (ADRD), chronic traumatic encephalopathy (CTE), and other neuropathologies, and their resulting clinical syndromes. The primary mission of the Data Coordinating Core (DCC) is to provide leadership and expertise in all phases of data management and statistical analyses, from development of project infrastructure to publication of results. This collaborative assistance encompasses data sharing, development of the analytic plan, database design, implementation of data collection and quality control procedures, technical support, creation of analytic datasets, statistical analyses, and manuscript preparation. Our overall aim is to provide procedural consistency and efficiency of study-wide systems, ultimately producing the highest quality data and analysis for use by study researchers and affiliates. DCC will harmonize data from the 8 novel brain banks: 6 at Boston University (BU): VA-BU-CLF or UNITE, Chronic Effects of Neurotrauma Consortium (CENC), Alzheimer's Disease Center (BUADC), VA Amyotrophic Lateral Sclerosis (ALS), VA Post-Traumatic Stress Disorder (PTSD) and Framingham Heart Study (FHS) brain banks and 2 at ISMMS : Late Effects of TBI (LETBI) and AD Research Center (ADRC). The main objectives of the DCC are to maintain an integrated, user-friendly data management system and to implement procedures to ensure the highest quality data, security, and integrity; to provide active and integral collaboration in methodological design and statistical analysis to all supported project investigators; and to provide systems and support for resource sharing across all study sites and collaborators. To accomplish these goals, we aim 1) to provide centralized data infrastructure using integrated, user-friendly systems for sharing of information, data, and analysis tools. 2) to provide centralized data management using integrated, user-friendly systems for sharing of information, data, and analysis tools; 3) to disseminate integrated datasets to accelerate the impact of the study's research objectives; 4) to provide high-level biostatistical expertise for all study's projects.