Southern New England Partnership In Stroke Research, Innovation and Treatment (SPIRIT)

新英格兰南部中风研究、创新和治疗合作伙伴关系 (SPIRIT)

• 批准号: 10460352
• 负责人: MARK Jay ALBERTS
• 金额: $ 32.74万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10460352
• 关键词: Academic Medical Centers; Acute; Adult; Agreement; American Heart Association; Area; Blood Vessels; Cause of Death; Characteristics; Childhood; Childhood stroke; Clinical; Clinical Management; Clinical Research; Clinical Trials; Clinical Trials Design; Clinical Trials Network; Collaborations; Communities; Community Hospitals; Computer software; Computerized Medical Record; Connecticut; Continuity of Patient Care; Critical Care; Development; Discipline; Disease; Education; Emergency Department Physician; Enrollment; Ethnic group; Faculty; Funding; Future; Generations; Geographic Locations; Goals; Healthcare; Hospitals; Human Subject Research; Image Enhancement; Infrastructure; Institution; Institutional Review Boards; International; Lead; Leadership; Massachusetts; Medical Records; Mentors; Mission; Modeling; Modernization; Monitor; Multicenter Studies; Multicenter Trials; National Institute of Neurological Disorders and Stroke; Neurologist; Neurology; Neurosurgeon; New England; Patients; Pediatric Hospitals; Persons; Policies; Preparation; Prevention; Principal Investigator; Protocols documentation; Quality Control; Records; Recovery; Rehabilitation therapy; Research; Research Personnel; Research Project Grants; Resource Sharing; Rhode Island; Science; Scientist; Specialist; Stroke; Stroke prevention; Structure; Sum; System; Talents; Teleconferences; Training; Training and Education; Translational Research; United States; United States National Institutes of Health; Universities; Vision; Work; acute stroke; base; biomarker development; care systems; clinical biomarkers; clinical care; clinical trial implementation; collaborative environment; community engagement; data management; data sharing; design; disability; ethnic diversity; experience; innovation; medical schools; meetings; member; multidisciplinary; nervous system disorder; next generation; operation; patient engagement; patient oriented research; patient population; programs; racial and ethnic; racial diversity; recruit; rural patients; rural setting; stroke clinical trials; stroke patient; stroke therapy; stroke trials; success; tool; urban setting

We propose the Southern New England Partnership In Stroke Research, Innovation and Treatment (SPIRIT), a StrokeNet Regional Coordinating Center (RCC) anchored by 3 leading institutions: Yale School of Medicine, the Warren Alpert School of Medicine at Brown University, and Hartford Hospital. Each Hub is a Comprehensive Stroke Center with 14 total Primary Stroke Centers. Yale is the 7th largest hospital in the United States, and in collaboration with Brown and Hartford Hospital, and their respective networks, SPIRIT captures a diverse geographic area that provides access to 5.7 million people, including most adult and pediatric stroke patients in Connecticut and Rhode Island. This robust patient volume (over 3500 total stroke patients in 2016), combined with an exceptionally strong collaborative and organizational framework, gives SPIRIT great potential for clinical trial implementation. Principal Investigators Dr. Kevin N. Sheth (Yale), Dr. Karen Furie (Brown), and Dr. Mark Alberts (Hartford Hospital) bring a complementary set of leadership and high-level clinical trials experience in stroke. Each leader brings well recognized expertise in international multicenter studies and implementation of stroke systems of care, as well as a track record of high quality stroke trial recruitment and retention. In various capacities, they have worked together for over 12 years, and each PI leads an enthusiastic cadre of faculty across disciplines, to create a highly collaborative environment focused on stroke research, multicenter trials, membership on Institutional Review Boards, clinical trial committees, and extensive mentoring in patient-oriented research. SPIRIT maintains strong connections to NIH funded CTSA networks and is further strengthened by the following characteristics: 1) A pool of talented investigators with nationally recognized clinical and translational research expertise in stroke; 2) Rich diversity (both ethnic/racial as well as urban/rural) of patients in Southern New England currently not captured by the existing StrokeNet network; 3) Active leadership and participation in stroke communities and stroke systems of care in the areas of statewide policy, continuity of care, American Heart Association collaborations and regional education; 4) Deep investigator and patient pools for all three areas of StrokeNet initiatives – prevention, acute treatment, and recovery; 5) Access to a range of specialized tools already harmonized across centers including a common electronic medical record system (EPIC) and RAPID software for acute stroke imaging, enhancing data sharing and collaboration; 6) Continuous commitment from all three institutions to the central IRB model and use of a Master Trial Agreement; 7) Rich science core with ongoing NIH funded stroke studies and multiple, active StrokeNet proposals currently under review; and 8) An education core designed to identify, support and accelerate the development of tomorrow's stroke investigators. The Yale, Brown, and Hartford stroke teams together – where the sum of the collaboration is even more exciting than each part – is poised to make significant contributions to enhance and further the mission of NINDS and StrokeNet to reduce the burden of neurological disease.

我们建议新英格兰南部中风研究、创新和治疗伙伴关系(SPIRIT)，一个 StrokeNet区域协调中心(RCC)由3家领先的机构组成：耶鲁大学医学院、 布朗大学沃伦·阿尔伯特医学院和哈特福德医院。每个枢纽都是一个综合体 卒中中心共有14个初级卒中中心。耶鲁大学是美国第七大医院，在 与布朗和哈特福德医院及其各自的网络合作，SPIRIT捕获了多样化的 为570万人提供服务的地理区域，包括大多数成人和儿童中风患者 康涅狄格州和罗德岛州。这一强劲的患者数量(2016年中风患者总数超过3500人)加在一起 具有非常强大的协作和组织框架，为SPIRIT提供了巨大的临床潜力 试行。主要研究人员凯文·N·谢斯博士(耶鲁)、凯伦·弗里博士(布朗)和马克博士 艾伯茨(哈特福德医院)带来了一套互补的领导力和高水平的临床试验经验 卒中。每一位领导人都在国际多中心研究和实施方面拥有公认的专业知识 中风护理系统，以及高质量中风试验招募和保留的记录。在各种情况下 他们在一起工作了12年以上，每个PI都领导着一支热情的教职员工队伍 跨学科，创造一个高度协作的环境，专注于中风研究、多中心试验、 机构审查委员会、临床试验委员会的成员，以及以患者为中心的广泛指导 研究。SPIRIT与NIH资助的CTSA网络保持着牢固的联系，并通过 以下特点：1)拥有一批具有国家公认的临床和 中风方面的翻译研究专长；2)丰富的患者多样性(包括种族/种族以及城市/农村) 在新英格兰南部，目前没有被现有的StrokeNet网络捕获；3)积极的领导力和 在全州范围的政策、护理的连续性、 美国心脏协会的合作和地区教育；4)面向所有人的深度研究人员和患者池 StrokeNet倡议的三个领域--预防、急性治疗和康复；5)获得一系列 各中心之间已经协调了专门的工具，包括一个通用的电子病历系统 (EPIC)和用于急性卒中成像的快速软件，加强数据共享和协作；6)持续 所有三家机构对中央IRB模式的承诺和主试验协议的使用；7)Rich 科学核心，正在进行的NIH资助的中风研究和目前正在进行的多项积极的中风网络建议 审查；和8)旨在确定、支持和加速未来发展的教育核心 中风调查员。耶鲁、布朗和哈特福德游泳队在一起-合作的总和 甚至比每个部分都更令人兴奋-准备做出重大贡献，以增强和进一步 NINDS和StrokeNet的使命是减轻神经系统疾病的负担。