Novel Interventions for Chemotherapy-Induced Neuropathy

针对化疗引起的神经病变的新干预措施

• 批准号: 10460950
• 负责人: Maryam B. Lustberg
• 金额: $ 20.33万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10460950
• 关键词: ARNT gene; Acoustic Stimulation; Address; Aging; Antidepressive Agents; Area; Argentine; Brain region; Breast Cancer Treatment; Breast Cancer survivor; Cancer Survivor; Cardiovascular system; Caregivers; Caring; Control Groups; Dancing; Data; Degenerative Disorder; Disease; Dopamine; Dose-Limiting; Equilibrium; Exercise; Exposure to; Failure; Fatigue; Feasibility Studies; Functional disorder; Future; Gait; Goals; Health; Home; Impairment; Incidence; Individual; Intervention; Knowledge; Measurable; Measurement; Measures; Moods; Motivation; Motor; Musculoskeletal Equilibrium; Music; Nervous System Trauma; Neuropathy; Oral; Outcome; Pain; Parkinson Disease; Patient Care; Patient Outcomes Assessments; Patients; Periodicity; Persons; Pharmaceutical Preparations; Phase; Physical activity; Pilot Projects; Prevention; Quality of life; Randomized; Randomized Clinical Trials; Regulation; Reporting; Research; Research Personnel; Sample Size; Sensory; Speed; Survivors; Symptoms; Testing; Toxic effect; Training; Training Programs; Walking; Work; age related; aging population; axon regeneration; base; cancer therapy; cardiovascular fitness; chemotherapy; chemotherapy induced neuropathy; duloxetine; evidence base; exercise program; experience; fall risk; falls; improved; innovation; intrinsic motivation; locomotor control; member; motor control; multidisciplinary; neurophysiology; novel; painful neuropathy; patient oriented; post intervention; pressure; primary endpoint; prospective; randomized controlled study; reduce symptoms; restoration; satisfaction; side effect; social; social stigma; survivorship; systemic inflammatory response; treatment center

Project Abstract: Cancer treatment causes dose-limiting sensory symptoms and postural control dysfunction (neuropathy) in up to 80% of breast cancer (BC) survivors, yet non-invasive treatments to restore motor control remain underdeveloped. To restore mobility, interventions that address motor control, patient-reported symptoms, and motivation to participate - in combination - are most likely to succeed. Thus, we propose to test effect of partnered Adapted Argentine Tango (Tango) as an ideal intervention to simultaneously target restoration of mobility and alleviation of symptoms through socially-motivated participation. Tango is moderate intensity social dance, adapted for individuals with mobility deficits, that delivers sensorimotor and cardiovascular training to rhythmic music. Tango promotes survivor participation through creative engagement and caregiver inclusion. Previous research by the investigators established Tango as feasible for aging survivors (up to 82 years) to engage in with high satisfaction and effects to neuropathy-related motor control deficits. Therefore, we propose to conduct a Phase II, randomized clinical trial investigating Tango in 52 BC survivors with neuropathy. Our overarching hypothesis is that Tango is associated with improved postural control (primary) as well as improved balance, locomotor control and patient-reported outcomes (PROs) (secondary) relative to an evidence- based home exercise program (HEX). Our rationale: Tango combines the effects of rhythmic auditory stimulation on postural control regulation; physical activity practice on neuromotor control and cardiovascular fitness; with social motivation to participate in treatment. Our long-term goal is to optimize prevention and treatment of neuropathy utilizing non-invasive, patient-centered treatment to improve motor control more definitively and more quickly for more people. Toward this goal, BC survivors with balance deficits associated with neuropathy will be randomly assigned to Tango or HEX training, twice per week, for an 8 week period. Using an intent-to-treat approach, this innovative pilot study will determine impact of Tango on (AIM1) 1) postural control; 2) balance; 3) PROs including sensory symptoms, pain, fatigue, mood, quality of life, and intrinsic motivation; as well as explore (AIM2) 4) locomotor control. These data will enable us to establish effect sizes and estimate sample size for a future trial that will investigate relationship of neuromotor control and PROs to structural changes in regions of the brain involved in motor control and planning, central dopamine regulation, and systemic inflammation among individuals with neurotrauma.

项目摘要：癌症治疗引起剂量限制性感觉症状和姿势控制功能障碍