Phenotype, dynamics and activation of myocardial B lymphocytes in response toischemia/reperfusion injury
心肌 B 淋巴细胞响应缺血/再灌注损伤的表型、动力学和激活
基本信息
- 批准号:10463823
- 负责人:
- 金额:$ 15.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-08-01 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAdultAreaAwardB-LymphocytesBasic ScienceBiologyBone MarrowCardiacCardiologyCardiovascular DiseasesCardiovascular systemCellular biologyClinicalClinical SciencesClinical TrialsDendritic CellsDevelopmentDevelopment PlansDevelopmental BiologyDiseaseDoctor of PhilosophyEmbryoEmbryonic DevelopmentEquilibriumGoalsGrowthHandednessHealthHealthcareHeartHeart InjuriesHeart TransplantationHeart failureHeterogeneityImmunologyImmunomodulatorsInflammationInflammatoryInflammatory ResponseInjuryInnate Immune ResponseInnate Immune SystemInstitutionInternal MedicineInternationalKnowledgeLeadLymphocyte FunctionMediatingMentorsMentorshipMonoclonal AntibodiesMyocardialMyocardial dysfunctionMyocardial tissueMyocardiumPatientsPhenotypePhysiciansPlayPopulationPostdoctoral FellowPrincipal InvestigatorReperfusion InjuryResearchResolutionResourcesRoleScientistSubgroupT-LymphocyteTestingTherapeuticTimeTrainingTranslatingUniversitiesWashingtonWorkbasecardiac repaircardiogenesiscardiovascular effectscareer developmentclinically relevantcytokinedisabilityexperiencehealthy agingheart damageimmunomodulatory strategyimmunoregulationinnovationlaboratory experiencemacrophagemonocytemortalitymyocardial injurypreventresponseside effectskillssmall moleculestemtherapeutic targettissue injurytissue repairtraffickingtranslational study
项目摘要
Project Summary/Abstract:
The goal of this proposal is to develop the Principal Investigator (PI) into an independent physician
scientist in the field of cardiovascular research. The PI has previously obtained PhD training in developmental
biology and has obtained additional training in basic and translational cardiovascular research. At this point in
time, the PI has completed clinical training in Internal Medicine, Cardiology, Advanced Heart Failure and
Cardiac Transplant and he is a post-doctoral research fellow (supported by T32 HL007081) in Dr. Douglas
Mann’s Lab. The following 5-year career development plan will provide the PI formal training in immunology
and ongoing laboratory training in the study of cardiac injury. At the conclusion of this award period, the PI will
have acquired the skills necessary to become an independent and successful physician scientist.
Dr. Douglas Mann, Chief of Cardiology at Washington University, will be the primary mentor of the PI.
Dr. Mann is a recognized leader in myocardial inflammation and has a tremendous breadth of experience in
cardiovascular research. His expertise spans from basic to clinical science where he has defined the role of
pro-inflammatory cytokines in heart failure and spearheaded a clinical trial based on his results. As such, he
serves as a perfect example of a successful physician scientist that is able to translate basic science research
into the clinical arena. The PI will take advantage of this mentorship along with the enormous basic science
and clinical resources available at Washington University (an internationally recognized premier academic
institution) to define a new area of clinically relevant basic science research.
Heart failure is one of the leading causes of disability and mortality related to cardiovascular disease
and single handedly drains almost 2% of total US healthcare spending. Recent evidence suggests that
modulation of myocardial B lymphocytes might provide an innovative therapeutic approach to reduce the
development of heart failure in patients that experienced heart damage. Unfortunately, our current
understanding of the biology of myocardial B lymphocytes is minimal. We recently found that myocardial B
lymphocytes are much more heterogeneous than what was previously appreciated. We identified several
subgroups of myocardial B cells and we showed that different sub-groups of myocardial B cells respond
differently to acute heart damage. In this proposal, we will test the hypothesis that the myocardium harbors
dynamic subpopulations of B lymphocytes with different ontogeny, that produce specific responses to acute
cardiac injury, and that B cells have antagonistic roles within the amplification/resolution balance of the
inflammatory response to cardiac damage.
项目概要/摘要:
该提案的目标是将主要研究者(PI)培养为独立的医生
心血管研究领域的科学家。PI此前已获得发展方面的博士培训
生物学,并获得了基础和转化心血管研究的额外培训。此时此刻
同时,PI已完成内科、心脏病学、晚期心力衰竭和
心脏移植,他是道格拉斯博士的博士后研究员(由T32 HL 007081支持)
曼的实验室。以下5年职业发展计划将为PI提供免疫学方面的正式培训
以及心脏损伤研究的持续实验室培训。在本奖励期结束时,PI将
已获得必要的技能,成为一个独立的和成功的医生科学家。
华盛顿大学心脏病学主任道格拉斯曼博士将是PI的主要导师。
博士Mann是心肌炎症领域公认的领导者,在以下方面拥有丰富的经验:
心血管研究他的专业知识涵盖从基础到临床科学,他定义了
心力衰竭中的促炎细胞因子,并率先基于他的结果进行了临床试验。所以他
作为一个成功的医生科学家的完美例子,能够将基础科学研究转化为
进入临床竞技场。PI将利用这种指导沿着巨大的基础科学
华盛顿大学(一所国际公认的一流学术机构)
机构),以确定临床相关的基础科学研究的新领域。
心力衰竭是心血管疾病致残和死亡的主要原因之一
仅这一项就消耗了美国医疗保健总支出的近2%。最近的证据表明
心肌B淋巴细胞的调节可能提供一种创新的治疗方法,以减少
发生心力衰竭的患者经历了心脏损伤。不幸的是,我们目前
对心肌B淋巴细胞的生物学了解很少。我们最近发现心肌B
淋巴细胞的异质性比以前认识到的要大得多。我们确定了几
心肌B细胞的亚群,我们表明,不同的心肌B细胞亚群的反应,
与急性心脏损伤不同。在这个提议中,我们将检验心肌含有
具有不同个体发育的动态B淋巴细胞亚群,对急性炎症反应产生特异性反应。
心肌损伤,B细胞在心肌细胞的放大/分辨率平衡中具有拮抗作用。
心脏损伤的炎症反应。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Luigi Adamo其他文献
Luigi Adamo的其他文献
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{{ truncateString('Luigi Adamo', 18)}}的其他基金
Myocardial-associated B lymphocytes and inflammatory injury
心肌相关B淋巴细胞与炎症损伤
- 批准号:
10543825 - 财政年份:2022
- 资助金额:
$ 15.06万 - 项目类别:
Myocardial-associated B lymphocytes and inflammatory injury
心肌相关B淋巴细胞与炎症损伤
- 批准号:
10339541 - 财政年份:2022
- 资助金额:
$ 15.06万 - 项目类别:
Phenotype, dynamics and activation of myocardial B lymphocytes in response toischemia/reperfusion injury
心肌 B 淋巴细胞响应缺血/再灌注损伤的表型、动力学和激活
- 批准号:
10261534 - 财政年份:2019
- 资助金额:
$ 15.06万 - 项目类别:
Phenotype, dynamics and activation of myocardial B lymphocytes in response toischemia/reperfusion injury
心肌 B 淋巴细胞响应缺血/再灌注损伤的表型、动力学和激活
- 批准号:
10689042 - 财政年份:2019
- 资助金额:
$ 15.06万 - 项目类别:
Phenotype, dynamics and activation of myocardial B lymphocytes in response toischemia/reperfusion injury
心肌 B 淋巴细胞响应缺血/再灌注损伤的表型、动力学和激活
- 批准号:
10251619 - 财政年份:2019
- 资助金额:
$ 15.06万 - 项目类别:
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