MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) FIELD CENTER (FC) - TASK AREA B EXAM 7

动脉粥样硬化的多种族研究(MESA)是一项关于相关因素、预测因素和 男性不同人群样本中亚临床心血管疾病(CVD)的进展 年龄在45-84岁的女性，基线时没有临床心血管疾病的证据。在最初的资助过程中 在MESA期间，在2000-2002年期间从6个外地中心招募了6814名参与者 使用计算机断层扫描检查亚临床冠状动脉粥样硬化的证据 MRI、颈动脉超声、血流介导的臂动脉扩张、桡动脉眼压测量、踝臂 指数测量和视网膜摄影。其他一些变量，包括腹主动脉 用于测量局部心肌功能的CT、颈动脉MRI、心脏MRI标记； 假定的实验室风险标记；社会经济、心理、行为和环境 特征；在MESA队列的子集中评估了遗传变异。考试 选定的成分在随后的五次检查中重复进行，时间跨度约为16 自基线以来，对临床心血管事件的队列进行了持续跟踪 考试。 本提案是为了响应NHLBI RFP(编号75N92020D00003，多种族研究)而写的 动脉粥样硬化(MESA)检查7-任务区域B)，旨在通过 梅萨参与者的梅萨现场中心。任务区B将涉及协议制定和 期末考试、备考活动、对所有幸存和有意愿的台地进行有限的复查 来自现场中心的参与者，以及考试7的收尾活动。考试7的招聘目标 所有外地中心约有3,000人参加。考试7的表现将允许 持续的科学合作。这将有助于实现第四个台地的下列科学目标： 1)增强对临床结果预测因素进行分析的统计能力，特别是在 提供信息的亚组；2)研究亚临床到临床心血管疾病的进展；3)确定新的风险 影响疾病病理生理学的因素或因素之间的相互作用。 这项研究将继续支持在NHLBI之外资助的深入辅助研究 合同。这些研究将在业务上纳入主要研究，并将共享数据 在整个“MESA套件”研究中，根据MESA和NIH当前的数据共享政策。这个 研究的数据将通过一个明确的程序提供给感兴趣的调查人员，该程序鼓励 最大限度地提高数据利用率，同时保护参与者的机密性。

The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the correlates, predictors, and progression of subclinical cardiovascular disease (CVD) in a diverse population-based sample of men and women aged 45-84 who had no evidence of clinical CVD at baseline. During the initial funding period of MESA, 6,814 participants were recruited from six field centers during 2000-2002 and examined for evidence of subclinical coronary atherosclerosis, using computed tomography, cardiac MRI, carotid ultrasound, flow-mediated brachial artery dilation, radial artery tonometry, ankle-brachial index measurement, and retinal photography. A number of other variables including abdominal aortic CT, carotid MRI, cardiac MRI tagging for measures of regional myocardial function; established and putative laboratory risk markers; socioeconomic, psychological, behavioral and environmental characteristics; and genetic variants were assessed in subsets of the MESA cohort. Examinations of selected components were repeated over five subsequent examinations spanning approximately 16 years and the cohort has been continuously followed for clinical CVD events since the baseline examination. This proposal is written in response to the NHLBI RFP (No. 75N92020D00003, Multi-Ethnic Study of Atherosclerosis (MESA) Exam 7- Task Area B) that seeks to enable a limited reexamination by the MESA field centers of MESA participants. Task Area B will involve protocol development and finalization, exam preparation activities, a limited re-examination of all surviving and willing MESA participants from the field center, and close-out activities for Exam 7. The recruitment goal for Exam 7 is approximately 3,000 participants across all field centers. The performance of Exam 7 will allow continued scientific collaborations. which will contribute to the following MESA IV scientific objectives: 1) enhance statistical power to perform analyses of predictors of clinical outcomes, particularly in informative subgroups; 2) study the progression of subclinical to clinical CVD; and 3) identify new risk factors or interactions among factors that inform disease pathophysiology. The study will continue to support in-depth ancillary studies that are funded outside of the NHLBI contract. These studies will be operationally integrated into the main study, and the data will be shared across the entire “MESA Suite” of studies, per current MESA and NIH data-sharing policies. The study’s data will be provided to interested investigators through a defined process that encourages maximum data utilization while protecting participant confidentiality.