MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) FIELD CENTER (FC) - TASK AREA B EXAM 7

多种族动脉粥样硬化研究（梅萨）是一项在45-84岁的男性和女性中进行的亚临床心血管疾病（CVD）的相关性，预测因素和进展的研究，这些男性和女性在基线时没有临床CVD的证据。在梅萨的初始资助期间，在2000-2002年期间从6个现场中心招募了6，814名参与者，并使用计算机断层扫描，心脏MRI，颈动脉超声，血流介导的肱动脉扩张，桡动脉张力测定，踝肱指数测量和视网膜摄影检查亚临床冠状动脉粥样硬化的证据。在梅萨队列的子集中评估了许多其他变量，包括腹主动脉CT、颈动脉MRI、心脏MRI标记以测量局部心肌功能;确定和推定的实验室风险标志物;社会经济、心理、行为和环境特征;以及遗传变异。在大约16年的5次后续检查中重复对选定组件进行检查，并且自基线检查以来，对该队列的临床CVD事件进行了连续随访。 本建议书是针对NHLBI RFP（编号75 N92020 D 00003，多种族动脉粥样硬化研究（梅萨）考试7-任务领域B）编写的，旨在使MESA现场中心能够对梅萨参与者进行有限的复查。任务区B将涉及方案制定和定稿、考试准备活动、对现场中心所有幸存和愿意参加梅萨的参与者进行有限的重新检查，以及考试7的收尾活动。考试7的招聘目标是在所有外地中心约3,000名参与者。考试7的表现将允许继续科学合作。这将有助于实现以下梅萨IV科学目标：1）增强统计能力，以进行临床结局预测因素分析，特别是在信息亚组中; 2）研究亚临床到临床CVD的进展; 3）确定新的风险因素或告知疾病病理生理学的因素之间的相互作用。 该研究将继续支持在NHLBI合同之外资助的深入辅助研究。这些研究将在操作上整合到主要研究中，并且根据当前的梅萨和NIH数据共享政策，数据将在整个“梅萨套件”研究中共享。本研究的数据将通过一个明确的过程提供给感兴趣的研究者，该过程鼓励最大限度地利用数据，同时保护受试者的机密性。

The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the correlates, predictors, and progression of subclinical cardiovascular disease (CVD) in a diverse population-based sample of men and women aged 45-84 who had no evidence of clinical CVD at baseline. During the initial funding period of MESA, 6,814 participants were recruited from six field centers during 2000-2002 and examined for evidence of subclinical coronary atherosclerosis, using computed tomography, cardiac MRI, carotid ultrasound, flow-mediated brachial artery dilation, radial artery tonometry, ankle-brachial index measurement, and retinal photography. A number of other variables including abdominal aortic CT, carotid MRI, cardiac MRI tagging for measures of regional myocardial function; established and putative laboratory risk markers; socioeconomic, psychological, behavioral and environmental characteristics; and genetic variants were assessed in subsets of the MESA cohort. Examinations of selected components were repeated over five subsequent examinations spanning approximately 16 years and the cohort has been continuously followed for clinical CVD events since the baseline examination. This proposal is written in response to the NHLBI RFP (No. 75N92020D00003, Multi-Ethnic Study of Atherosclerosis (MESA) Exam 7- Task Area B) that seeks to enable a limited reexamination by the MESA field centers of MESA participants. Task Area B will involve protocol development and finalization, exam preparation activities, a limited re-examination of all surviving and willing MESA participants from the field center, and close-out activities for Exam 7. The recruitment goal for Exam 7 is approximately 3,000 participants across all field centers. The performance of Exam 7 will allow continued scientific collaborations. which will contribute to the following MESA IV scientific objectives: 1) enhance statistical power to perform analyses of predictors of clinical outcomes, particularly in informative subgroups; 2) study the progression of subclinical to clinical CVD; and 3) identify new risk factors or interactions among factors that inform disease pathophysiology. The study will continue to support in-depth ancillary studies that are funded outside of the NHLBI contract. These studies will be operationally integrated into the main study, and the data will be shared across the entire “MESA Suite” of studies, per current MESA and NIH data-sharing policies. The study’s data will be provided to interested investigators through a defined process that encourages maximum data utilization while protecting participant confidentiality.