MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) FIELD CENTER (FC) - TASK AREA B EXAM 7

动脉粥样硬化的多种族研究(MESA)是一项关于亚临床心血管疾病(CVD)的相关性、预测因素和进展的研究，研究对象为年龄在45-84岁之间、在基线时没有临床心血管疾病证据的男性和女性。在MESA的最初资助期间，在2000-2002年间，从6个外地中心招募了6814名参与者，并使用计算机断层扫描、心脏MRI、颈动脉超声、血流介导的臂动脉扩张、放射状动脉眼压测量、踝臂指数测量和视网膜摄影来检查亚临床冠状动脉粥样硬化的证据。在MESA队列的亚组中评估了一些其他变量，包括腹主动脉CT、颈动脉MRI、心脏MRI标记以测量局部心肌功能；已建立和假定的实验室风险标记物；社会经济、心理、行为和环境特征；以及遗传变异。对选定成分的检查在随后的五次检查中重复进行，时间跨度约为16年，自基线检查以来，一直在跟踪队列的临床心血管事件。 本提案是为了响应NHLBI RFP(编号75N92020D00003，动脉粥样硬化(MESA)多种族研究(MESA)考试7-任务区域B)而写的，该考试旨在允许MESA参与者的MESA现场中心进行有限的复查。任务区B将涉及方案制定和定稿、考试准备活动、对外地中心所有幸存和愿意参加的MESA参与者进行的有限复试，以及考试7的收尾活动。考试7的招募目标是所有外地中心的约3,000名参与者。考试7的表现将允许继续进行科学合作。这将有助于MESA IV的以下科学目标：1)增强对临床结果预测因素的统计能力，特别是在信息丰富的亚组中；2)研究亚临床到临床心血管疾病的进展；以及3)确定新的风险因素或提供疾病病理生理信息的因素之间的相互作用。 这项研究将继续支持在NHLBI合同之外资助的深入辅助研究。这些研究将在业务上整合到主要研究中，根据目前的MESA和NIH的数据共享政策，数据将在整个MESA研究套件中共享。这项研究的数据将通过一个明确的程序提供给感兴趣的调查人员，该程序鼓励最大限度地利用数据，同时保护参与者的机密性。

The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the correlates, predictors, and progression of subclinical cardiovascular disease (CVD) in a diverse population-based sample of men and women aged 45-84 who had no evidence of clinical CVD at baseline. During the initial funding period of MESA, 6,814 participants were recruited from six field centers during 2000-2002 and examined for evidence of subclinical coronary atherosclerosis, using computed tomography, cardiac MRI, carotid ultrasound, flow-mediated brachial artery dilation, radial artery tonometry, ankle-brachial index measurement, and retinal photography. A number of other variables including abdominal aortic CT, carotid MRI, cardiac MRI tagging for measures of regional myocardial function; established and putative laboratory risk markers; socioeconomic, psychological, behavioral and environmental characteristics; and genetic variants were assessed in subsets of the MESA cohort. Examinations of selected components were repeated over five subsequent examinations spanning approximately 16 years and the cohort has been continuously followed for clinical CVD events since the baseline examination. This proposal is written in response to the NHLBI RFP (No. 75N92020D00003, Multi-Ethnic Study of Atherosclerosis (MESA) Exam 7- Task Area B) that seeks to enable a limited reexamination by the MESA field centers of MESA participants. Task Area B will involve protocol development and finalization, exam preparation activities, a limited re-examination of all surviving and willing MESA participants from the field center, and close-out activities for Exam 7. The recruitment goal for Exam 7 is approximately 3,000 participants across all field centers. The performance of Exam 7 will allow continued scientific collaborations. which will contribute to the following MESA IV scientific objectives: 1) enhance statistical power to perform analyses of predictors of clinical outcomes, particularly in informative subgroups; 2) study the progression of subclinical to clinical CVD; and 3) identify new risk factors or interactions among factors that inform disease pathophysiology. The study will continue to support in-depth ancillary studies that are funded outside of the NHLBI contract. These studies will be operationally integrated into the main study, and the data will be shared across the entire “MESA Suite” of studies, per current MESA and NIH data-sharing policies. The study’s data will be provided to interested investigators through a defined process that encourages maximum data utilization while protecting participant confidentiality.