Psychoactive Drug Screening (PDSP)

精神活性药物筛选（PDSP）

• 批准号: 10469970
• 负责人: BRYAN ROTH
• 金额: $ 297.69万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-30 至 2021-08-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10469970
• 关键词: Basic Science; Behavioral; Biochemical; Brain imaging; Chemistry; Clinical Research; Drug Screening; Functional Magnetic Resonance Imaging; Funding; Imaging ligands; Lead; Libraries; Mental disorders; National Institute of Mental Health; Natural Products; Pharmacology; Positron-Emission Tomography; Psychotropic Drugs; Research; Therapeutic Agents; United States National Institutes of Health; combinatorial; high throughput screening; novel; programs; screening; single photon emission computed tomography; tool

The purpose of the NIMH PDSP is to provide screening of novel synthetic compounds and natural products for potential use as research tools or probes for basic and clinical research, as therapeutic agents for mental disorders, and as positron emission tomography (PET), single photon emission computed tomography (SPECT), and functional magnetic resonance imaging (fMRI) ligands for functional brain imaging. This program is primarily intended as a screen for compounds that have previously been shown to possess pharmacological, biochemical, or behavioral activities relevant to NIMH and not for the purpose of large-scale, random screening of natural products or combinatorial libraries (e.g., libraries containing >1000 compounds). However, screening maybe conducted on small libraries of synthetic or natural product compounds of unknown activity and on hit or lead compounds generated through NIH-funded high throughput screening (HTS) or chemistry programs.

NIMH PDSP 的目的是筛选新型合成化合物和天然产物 潜在用途作为基础和临床研究的研究工具或探针，作为精神障碍的治疗剂， 以及正电子发射断层扫描 (PET)、单光子发射计算机断层扫描 (SPECT) 和功能性断层扫描 用于功能性脑成像的磁共振成像（fMRI）配体。 该程序的主要目的是筛选以前已被证明具有 与 NIMH 相关的药理学、生化或行为活动，不以大规模、随机为目的 筛选天然产物或组合文库（例如，包含 >1000 种化合物的文库）。然而， 可以对活性未知的合成或天然产物化合物的小型文库进行筛选 通过 NIH 资助的高通量筛选 (HTS) 或化学项目产生的命中或先导化合物。