The impact of a resistance training intervention on blood pressure control in older adults with Sarcopenia

项目总结/摘要 K 01的总体目标是获得指导性的职业发展，以提高Laddu博士成为 慢性病预防的独立研究员，专注于开发务实和可扩展的 通过预防高度普遍的衰老状况（即， 肌肉减少症和高血压）。通过（1）临床试验设计和 行为健康促进干预行为，包括定性和定量 方法论，将使Laddu博士能够很好地设计针对行为的多因素干预措施。 危险因素和影响健康状况。本K 01提案的前提是解决 文献关于高血压的理解，由于肌肉减少症，并提供新的证据， 低肌肉力量和BP在肌肉减少症中的可辨别的关系，以及有效的非药物 治疗方法。在最科学严谨的方式，博士Laddu将评估的可行性， 招募，保留，实施和坚持以实践为基础的渐进式阻力训练 (PRT)干预，以测试其对患有肌肉减少症的老年人目标人群的BP的影响， 随机（通过区组排列方案）分配至PRT干预。在这个随机对照组中 干预设计，Laddu博士将进一步探索可逆性，以检查肌肉力量是否作为 肌肉减少症成人血压控制的干预目标，随后将更适当地进行测试 高效能的R级干预研究。PRT影响的生理学合理机制 BP的变化也将通过她的导师学习的技术进行探索。通过这次实践经验， 博士Laddu将获得有关内部和人际行为和障碍的见解， 体育活动和健康促进，并学习如何促进可操作的，可扩展的生活方式和行为 适用于老年人、高危人群的策略。经验将与交叉补充- 将通过综合职业发展计划完成纪律培训，该计划包括 正式的课程和研讨会，她的高技能的高级导师的指导和保证保护的时间 以获得实际的研究经验，并利用丰富的环境，研究与老年人在 伊利诺伊大学芝加哥分校。通过K 01职业发展申请获得的培训和技能 将加强她在健康促进方面的研究轨迹，并成功地过渡到一个完全独立的 调查员重要的是，K 01将为Laddu博士建立一个研究组合奠定基础， 确定解决方案，为当前的卫生保健指南提供有效和实用的解决方案， 预防，治疗和管理BP，以及BP相关的心血管疾病（CVD） 患有影响不断增长的老年人口的肌肉缺陷或类似的衰弱状况。

Project Summary/Abstract The overall goal of the K01 will be to gain mentored career development to enhance Dr. Laddu's ability to become an independent researcher in chronic disease prevention with a focus on developing pragmatic and scalable interventions to lower or control blood pressure (BP) by preventing highly prevalent aging conditions (i.e., sarcopenia and hypertension). The knowledge and experience acquired through (1) clinical trial design and conduct, and (2) behavioral health promotion intervention conduct, including qualitative and quantitative methodologies, will make Dr. Laddu well-equipped to design multifactorial interventions that target behavioral risk factors and influence health status. This premise of this K01 proposal is to address current gaps in the literature regarding the understanding of high BP due to sarcopenia, and provide new evidence for the discernable relationship between low muscle strength and BP in sarcopenia, and effective non-pharmaceutical treatment approaches. In the most scientifically rigorous manner, Dr. Laddu will evaluate the feasibility of recruitment, retention, implementation and adherence to an empirically-based progressive resistance training (PRT) intervention to test its effect on BP in a targeted population of older adults with sarcopenia who are randomized (via block permuted scheme) to the PRT intervention. Built within this randomized control intervention design, Dr. Laddu will further explore reversibility to examine whether muscle strength serves as an intervention target for BP control in sarcopenic adults, which will be more appropriately tested in subsequently well-powered R-level intervention studies. Physiologically plausible mechanisms by which the PRT impacts changes in BP will also be explored through learned techniques by her mentor. Through this practical experience, Dr. Laddu will acquire insights relative to the intra- and inter-personal behaviors and barriers associated with physical activity and health promotion, and learn how to promote actionable, and scalable lifestyle and behavior strategies that are applicable to and older, high-risk population. Experience will be complemented with cross- disciplinary training which will be accomplished through an integrated career development plan that consists of formal coursework and seminars, guidance from her highly skilled senior mentors and guaranteed protected time to gain practical research experience, and leverages the rich environment for research with older adults at the University of Illinois at Chicago. The training and skills acquired through the K01 career development application will strengthen her research trajectory in health promotion and successfully transition to a fully independent investigator. Importantly, this K01 will set the foundation for Dr. Laddu to build a research portfolio focused on identifying solutions that inform current health care guidelines on effective and practical solutions for the prevention, treatment, and management of BP, and BP-related cardiovascular diseases (CVD) among those suffering from muscular deficits or similar debilitating conditions that affect the growing geriatric population.