The impact of a resistance training intervention on blood pressure control in older adults with Sarcopenia

项目摘要/摘要 K01的总体目标将是获得指导的职业发展，以增强拉杜博士成为 慢性疾病预防方面的独立研究人员，专注于开发实用和可扩展的 通过防止高度普遍的衰老状况(即， 石棺减少和高血压)。通过(1)临床试验设计和试验获得的知识和经验 行为；(2)行为健康促进干预行为，包括定性和定量 方法，将使拉杜博士能够很好地设计针对行为的多因素干预 风险因素和影响健康状况。这项K01提案的前提是解决目前在 关于骨质疏松症引起的高血压的理解的文献，并为 骨质疏松症中肌力低下与血压的可辨别关系，以及有效的非药物治疗 治疗方法正在接近。拉杜博士将以最科学、最严谨的方式评估 招募、保留、实施和坚持以经验为基础的渐进抵抗训练 (PRT)干预，以测试其对目标人群的血压影响，这些老年人患有石棺减少症 随机(通过区块置换方案)进行PRT干预。建立在这种随机对照中 干预设计，拉杜博士将进一步探索可逆性，以检查肌肉力量是否作为 骨质疏松症成人血压控制的干预目标，将在随后进行更合适的测试 强大的R级干预研究。PRT影响的生理上合理的机制 她的导师还将通过学习的技术来探索BP的变化。通过这次实践经验， Laddu博士将获得与以下相关的个人内部和个人间行为和障碍的洞察力 体育活动和健康促进，并学习如何促进可操作的、可扩展的生活方式和行为 适用于老年和高危人群的战略。体验将与交叉- 纪律培训，将通过综合职业发展计划完成，该计划包括 正式的课程和研讨会，高技能的高级导师的指导，以及有保障的时间 获取实际研究经验，并利用丰富的环境与老年人在 伊利诺伊大学芝加哥分校。通过K01职业发展应用程序获得的培训和技能 将加强她在健康促进方面的研究轨迹，并成功过渡到完全独立的 调查员。重要的是，这一K01将为拉杜博士建立一个专注于 确定解决方案，为当前的卫生保健指南提供有效和实用的解决方案 预防、治疗和管理BP以及与BP相关的心血管疾病 患有肌肉缺陷或类似的衰弱状况，影响到日益增长的老年人口。

Project Summary/Abstract The overall goal of the K01 will be to gain mentored career development to enhance Dr. Laddu's ability to become an independent researcher in chronic disease prevention with a focus on developing pragmatic and scalable interventions to lower or control blood pressure (BP) by preventing highly prevalent aging conditions (i.e., sarcopenia and hypertension). The knowledge and experience acquired through (1) clinical trial design and conduct, and (2) behavioral health promotion intervention conduct, including qualitative and quantitative methodologies, will make Dr. Laddu well-equipped to design multifactorial interventions that target behavioral risk factors and influence health status. This premise of this K01 proposal is to address current gaps in the literature regarding the understanding of high BP due to sarcopenia, and provide new evidence for the discernable relationship between low muscle strength and BP in sarcopenia, and effective non-pharmaceutical treatment approaches. In the most scientifically rigorous manner, Dr. Laddu will evaluate the feasibility of recruitment, retention, implementation and adherence to an empirically-based progressive resistance training (PRT) intervention to test its effect on BP in a targeted population of older adults with sarcopenia who are randomized (via block permuted scheme) to the PRT intervention. Built within this randomized control intervention design, Dr. Laddu will further explore reversibility to examine whether muscle strength serves as an intervention target for BP control in sarcopenic adults, which will be more appropriately tested in subsequently well-powered R-level intervention studies. Physiologically plausible mechanisms by which the PRT impacts changes in BP will also be explored through learned techniques by her mentor. Through this practical experience, Dr. Laddu will acquire insights relative to the intra- and inter-personal behaviors and barriers associated with physical activity and health promotion, and learn how to promote actionable, and scalable lifestyle and behavior strategies that are applicable to and older, high-risk population. Experience will be complemented with cross- disciplinary training which will be accomplished through an integrated career development plan that consists of formal coursework and seminars, guidance from her highly skilled senior mentors and guaranteed protected time to gain practical research experience, and leverages the rich environment for research with older adults at the University of Illinois at Chicago. The training and skills acquired through the K01 career development application will strengthen her research trajectory in health promotion and successfully transition to a fully independent investigator. Importantly, this K01 will set the foundation for Dr. Laddu to build a research portfolio focused on identifying solutions that inform current health care guidelines on effective and practical solutions for the prevention, treatment, and management of BP, and BP-related cardiovascular diseases (CVD) among those suffering from muscular deficits or similar debilitating conditions that affect the growing geriatric population.