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DNAMIC - DNA Microfactory for Autonomous Archiving

DNAMIC - 用于自主存档的 DNA 微工厂

基本信息

批准号：
10086666
负责人：
金额：
$ 81.06万
依托单位：
IMPERIAL COLLEGE LONDON
依托单位国家：
英国
项目类别：
EU-Funded
财政年份：
2023
资助国家：
英国
起止时间：
2023 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=10086666
关键词：
DNAMIC DNA Microfactory Autonomous Archiving

项目摘要

We live in a society that produces and requires more and more data every year. It has become apparent that our current data storage strategies are not adequate to meet this increasing demand. The quest for robust, high-density, sustainable, and economically viable data storage solutions has highlighted the enormous potential and suitability of DNA data storage. However, to date, none of the solutions have considered a comprehensive vision of anchoring this technology in standardised archival frameworks that will support long-term storage. Besides, most DNA data storage applications are limited to specialist laboratories due to complex (and expensive) protocols. Our project entitled DNAMIC (DNA Microfactory for Autonomous Archiving) proposes an autonomous solution based around a low energy consumption microfactory that will be developed for end-to-end DNA data archiving(from encoding to decoding via synthesis, storage, quality control and sequencing among others). The microfactory is interoperable and future proof thanks to technology block that can be easily modified or replaced. Our solution will be compliant with the Open Archival Information System (OAIS) reference model (ISO 14721). To enable the implementation of disaster recovery strategies, critical for long term storage, we propose a novel dual-level encoding scheme. This approach allows the development of self-contained data that include easily changeable metadata, and unalterable data.

我们生活在一个每年产生和需要越来越多数据的社会。很明显，我们当前的数据存储策略不足以满足这种不断增长的需求。对强大、高密度、可持续和经济上可行的数据存储解决方案的追求凸显了DNA数据存储的巨大潜力和适用性。然而，到目前为止，没有一个解决方案考虑将这项技术锚定在支持长期存储的标准化归档框架中的全面愿景。此外，由于复杂（和昂贵）的协议，大多数DNA数据存储应用仅限于专业实验室。我们的项目名为DNAMIC（DNA Micofactory for Autonomous DNA），提出了一种基于低能耗微工厂的自主解决方案，该解决方案将用于端到端DNA数据存档（从编码到解码，通过合成，存储，质量控制和测序等）。由于技术模块可以轻松修改或替换，因此微型工厂具有互操作性和未来性。我们的解决方案将符合开放式档案信息系统（OAIS）参考模型（ISO 14721）。为了实现灾难恢复策略，长期存储的关键，我们提出了一种新的双层编码方案。这种方法允许开发自包含的数据，其中包括易于更改的元数据和不可更改的数据。