DNAMIC - DNA Microfactory for Autonomous Archiving

我们生活在一个每年产生和需要越来越多数据的社会。很明显，我们当前的数据存储策略不足以满足这种不断增长的需求。对强大、高密度、可持续和经济可行的数据存储解决方案的追求突显了DNA数据存储的巨大潜力和适用性。然而，到目前为止，没有一个解决方案考虑到将这项技术固定在支持长期存储的标准化档案框架中的全面愿景。此外，由于复杂(和昂贵)的协议，大多数DNA数据存储应用仅限于专业实验室。我们的项目名为DNAMIC(用于自主归档的DNA微工厂)，提出了一个基于低能耗微工厂的自主解决方案，该微工厂将为端到端的DNA数据归档(从编码到解码，通过合成、存储、质量控制和排序等)而开发。微工厂是可互操作的，而且是未来的证明，这要归功于可以很容易地修改或更换的技术块。我们的解决方案将符合开放式档案信息系统参考模型(国际标准化组织14721)。为了能够实施对长期存储至关重要的灾难恢复策略，我们提出了一种新的双层编码方案。这种方法允许开发自包含的数据，包括容易更改的元数据和不可更改的数据。

We live in a society that produces and requires more and more data every year. It has become apparent that our current data storage strategies are not adequate to meet this increasing demand. The quest for robust, high-density, sustainable, and economically viable data storage solutions has highlighted the enormous potential and suitability of DNA data storage. However, to date, none of the solutions have considered a comprehensive vision of anchoring this technology in standardised archival frameworks that will support long-term storage. Besides, most DNA data storage applications are limited to specialist laboratories due to complex (and expensive) protocols. Our project entitled DNAMIC (DNA Microfactory for Autonomous Archiving) proposes an autonomous solution based around a low energy consumption microfactory that will be developed for end-to-end DNA data archiving(from encoding to decoding via synthesis, storage, quality control and sequencing among others). The microfactory is interoperable and future proof thanks to technology block that can be easily modified or replaced. Our solution will be compliant with the Open Archival Information System (OAIS) reference model (ISO 14721). To enable the implementation of disaster recovery strategies, critical for long term storage, we propose a novel dual-level encoding scheme. This approach allows the development of self-contained data that include easily changeable metadata, and unalterable data.