Ambulatory Assessment of Simultaneous Alcohol and Marijuana Use: Impact on Alcohol Use and Consequences

项目摘要/摘要 通过本K08提案中描述的研究和培训活动，PI将获得必要的技能 成为酒精联合使用行为综合研究的独立临床科学研究员。 除了烟草，酒精和大麻是全国范围内最常用的物质，也是最 经常联合使用。随着大麻在美国的迅速合法化，共同使用率很可能 将继续上升，特别是在目前报告使用率最高的年轻人中。尽管 结合立法变化和公众对大麻接受度的上升，人们对大麻的来源知之甚少 同时使用酒精和大麻(SAM)会影响酒精行为。此外，生活必需品 实验室研究(例如，低效大麻、受控饮酒环境)给研究带来了挑战 使用SAM的影响。拟议研究的目的是检查SAM的使用是否会导致 利用动态评估(AA)方法研究饮酒情况和后果。AA涉及 整合评估方法(例如，自我报告、行为、生理)来研究个人 他们的自然环境。这项拟议的研究将是第一次使用新的行为评估 去抑制和运动损伤以及酒精使用的生物学措施(经皮酒精浓度： TAC)研究SAM的使用在活动层面对酒精消费的影响以及在日常生活中的后果 水平。这项研究涉及从年轻人(N=80)经常饮酒和吸食大麻的人那里收集原始数据 世卫组织将在佩戴酒精生物传感器评估TAC的同时，完成为期4周的AA数据收集。一个 自我发起和随机报告的酒精和大麻使用，主观醉酒，和 渴望；结合去抑制和运动障碍(步态和平衡)的行为评估将是 收好了。PI将与一支令人印象深刻的指导团队合作，该团队在四个月中拥有丰富的经验 培训领域：1)酒精和大麻联合使用的行为和药理学效应(Jane Metrik， 博士)；2)动态评估(罗伯特·米兰达博士；蒂莫西·特鲁尔博士)；3)酒精生物传感器技术 (南希·巴尼特博士)和4)高级统计分析(克里斯蒂娜·杰克逊博士)。建议的5年 培训计划将为PI作为一名具有酒精联合使用研究专业知识的临床科学家的职业生涯做好准备 行为；最终目标是进行混合方法设计以捕获受控对象的行为 实验室条件和自然环境。研究和培训将在酒精中心进行 以及布朗大学的成瘾研究(CAAS)。中国科学院是一个致力于研究的跨学科中心。 以及上瘾研究方面的培训。拟议中的研究将促进我们对机制的理解 SAM的使用通过建立在从受控人员那里获得的知识来影响酒精使用和后果 实验室研究。结果将为政策、预防和干预工作提供信息，以减少负面影响 与同时使用酒精和大麻有关的结果。

Project Summary/Abstract Through research and training activities described in this K08 proposal, the PI will acquire the skills necessary to become an independent clinical science researcher in the comprehensive study of alcohol co-use behaviors. Aside from tobacco, alcohol and marijuana are the most commonly used substances nationwide, and the most frequently co-used. With the rapid legalization of marijuana in the United States, it is likely that rates of co-use will continue to rise, particularly among young adults who currently report the highest rates of use. Despite the combined legislative changes and rising public acceptance of marijuana, little is known about how simultaneous use of alcohol and marijuana (SAM) impacts alcohol behaviors. Additionally, necessities of laboratory research (e.g. lower potency marijuana, controlled drinking contexts) present challenges in studying the effects of SAM use. The purpose of the proposed study is to examine whether SAM use leads to increased alcohol consumption and consequences by utilizing ambulatory assessment (AA) methodology. AA involves the integration of assessment methodologies (e.g. self-report, behavioral, physiological) to study individuals in their natural environment. The proposed study would be the first to employ novel behavioral assessments of disinhibition and motor impairment and biological measures of alcohol use (transdermal alcohol concentration: TAC) to study the impact of SAM use on alcohol consumption at the event level and consequences at the daily level. The study involves original data collection from young adult regular alcohol and marijuana users (N=80) who will complete 4 weeks of AA data collection while wearing alcohol biosensors to assess TAC. A combination of self-initiated and random reports of alcohol and marijuana use, subjective intoxication, and craving; paired with behavioral assessment of disinhibition and motor impairment (gait and balance) will be collected. The PI will collaborate with an impressive mentorship team carrying extensive experience in four areas of training: 1) behavioral and pharmacological effects of alcohol and marijuana co-use (Jane Metrik, PhD); 2) ambulatory assessment (Robert Miranda, PhD; Timothy Trull, PhD); 3) alcohol biosensor technology (Nancy Barnett, PhD); and 4) advanced statistical analyses (Kristina Jackson, PhD). The proposed 5-year training plan will prepare the PI for a career as a clinical scientist with expertise in the study of alcohol co-use behaviors; with the ultimate goal of conducting mixed-method designs to capture behavior in controlled laboratory conditions and the natural environment. Research and training will occur at the Center for Alcohol and Addiction Studies (CAAS) at Brown University. CAAS is an interdisciplinary center devoted to research and training in the study of addiction. The proposed research will advance our understanding of mechanisms by which SAM use impacts alcohol use and consequences by building on knowledge gained from controlled laboratory research. Results will inform policy, prevention, and intervention efforts to reduce the negative outcomes associated with simultaneous use of alcohol and marijuana.