Ambulatory Assessment of Simultaneous Alcohol and Marijuana Use: Impact on Alcohol Use and Consequences

项目总结/摘要 通过本K08提案中描述的研究和培训活动，PI将获得必要的技能 成为酒精共同使用行为综合研究的独立临床科学研究员。 除了烟草，酒精和大麻是全国最常用的物质， 经常使用。随着大麻在美国的迅速合法化， 将继续上升，特别是在目前报告使用率最高的年轻人中。尽管 结合立法的变化和公众对大麻的接受程度，人们对大麻是如何被接受的知之甚少。 同时使用酒精和大麻（SAM）会影响酒精行为。此外， 实验室研究（例如，低效力大麻，控制饮酒环境）在研究中提出了挑战 使用SAM的影响。拟议研究的目的是检查SAM的使用是否会导致 酒精消费和后果，利用流动评估（AA）方法。AA涉及 整合评估方法（如自我报告，行为，生理），以研究个人在 他们的自然环境。这项拟议的研究将是第一个采用新的行为评估， 抑制解除和运动障碍以及酒精使用的生物学测量（透皮酒精浓度： TAC）研究SAM使用对事件层面的酒精消耗的影响以及对日常生活的影响。 水平这项研究涉及从年轻的成年人经常饮酒和吸食大麻的原始数据收集（N = 80） 他们将完成4周的AA数据收集，同时佩戴酒精生物传感器以评估TAC。一 结合自我发起和随机报告的酒精和大麻的使用，主观中毒， 渴望;与抑制解除和运动障碍（步态和平衡）的行为评估配对， 收集。PI将与一个令人印象深刻的导师团队合作，在四个方面拥有丰富的经验。 训练领域：1）酒精和大麻共同使用的行为和药理学作用（JaneMetrik， 博士）; 2）门诊评估（Robert米兰达，博士; Timothy特吕尔尔，博士）; 3）酒精生物传感器技术 （Nancy巴内特，博士）;和4）高级统计分析（Kristina杰克逊，博士）。拟议的五年 培训计划将使PI成为具有酒精共同使用研究专业知识的临床科学家 行为;最终目标是进行混合方法设计以捕获受控环境中的行为 实验室条件和自然环境。研究和培训将在酒精中心进行， 和成瘾研究（CAAS）在布朗大学。CAAS是一个致力于研究的跨学科中心 和成瘾研究的培训。这项拟议中的研究将促进我们对机制的理解 SAM的使用影响酒精的使用和后果， 实验室研究研究结果将为政策、预防和干预工作提供信息，以减少 与同时使用酒精和大麻相关的结果。

Project Summary/Abstract Through research and training activities described in this K08 proposal, the PI will acquire the skills necessary to become an independent clinical science researcher in the comprehensive study of alcohol co-use behaviors. Aside from tobacco, alcohol and marijuana are the most commonly used substances nationwide, and the most frequently co-used. With the rapid legalization of marijuana in the United States, it is likely that rates of co-use will continue to rise, particularly among young adults who currently report the highest rates of use. Despite the combined legislative changes and rising public acceptance of marijuana, little is known about how simultaneous use of alcohol and marijuana (SAM) impacts alcohol behaviors. Additionally, necessities of laboratory research (e.g. lower potency marijuana, controlled drinking contexts) present challenges in studying the effects of SAM use. The purpose of the proposed study is to examine whether SAM use leads to increased alcohol consumption and consequences by utilizing ambulatory assessment (AA) methodology. AA involves the integration of assessment methodologies (e.g. self-report, behavioral, physiological) to study individuals in their natural environment. The proposed study would be the first to employ novel behavioral assessments of disinhibition and motor impairment and biological measures of alcohol use (transdermal alcohol concentration: TAC) to study the impact of SAM use on alcohol consumption at the event level and consequences at the daily level. The study involves original data collection from young adult regular alcohol and marijuana users (N=80) who will complete 4 weeks of AA data collection while wearing alcohol biosensors to assess TAC. A combination of self-initiated and random reports of alcohol and marijuana use, subjective intoxication, and craving; paired with behavioral assessment of disinhibition and motor impairment (gait and balance) will be collected. The PI will collaborate with an impressive mentorship team carrying extensive experience in four areas of training: 1) behavioral and pharmacological effects of alcohol and marijuana co-use (Jane Metrik, PhD); 2) ambulatory assessment (Robert Miranda, PhD; Timothy Trull, PhD); 3) alcohol biosensor technology (Nancy Barnett, PhD); and 4) advanced statistical analyses (Kristina Jackson, PhD). The proposed 5-year training plan will prepare the PI for a career as a clinical scientist with expertise in the study of alcohol co-use behaviors; with the ultimate goal of conducting mixed-method designs to capture behavior in controlled laboratory conditions and the natural environment. Research and training will occur at the Center for Alcohol and Addiction Studies (CAAS) at Brown University. CAAS is an interdisciplinary center devoted to research and training in the study of addiction. The proposed research will advance our understanding of mechanisms by which SAM use impacts alcohol use and consequences by building on knowledge gained from controlled laboratory research. Results will inform policy, prevention, and intervention efforts to reduce the negative outcomes associated with simultaneous use of alcohol and marijuana.