Data & Stats Core

数据

• 批准号: 10475317
• 负责人: Michael William Lutz
• 金额: $ 39.82万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10475317
• 关键词: Alzheimer' s Disease; Alzheimer' s disease related dementia; Big Data; Biocompatible Materials; Bioinformatics; Biological; Biological Markers; Clinical; Clinical Data; Collaborations; Communities; Consent Forms; Consultations; Custom; Data; Data Analyses; Data Collection; Data Set; Databases; Dementia; Development; Disease; Ensure; Epidemiology; Faculty; Genetic; Gerontology; Grant; Image; Infrastructure; Leadership; Longevity; Measurement; Mediating; Mentors; Methodology; Methods; Modeling; Participant; Prevention; Proteomics; Publishing; Quality Control; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Research Support; Sampling; Schedule; Scientist; Security; Specimen; Statistical Data Interpretation; Statistical Study; System; United States National Institutes of Health; Work; age related; cohort; data cleaning; data communication; data format; data management; data sharing; design; education research; experience; genetic analysis; genetic variant; genomic data; innovation; interest; large datasets; large scale data; metabolomics; multimodality; neuroimaging; query tools; statistics; transcriptomics; user-friendly

ABSTRACT - DATA MANAGEMENT AND STATISTICS CORE The Duke/UNC Alzheimer’s Disease Research Center (ADRC) Data Management and Statistics Core provides essential support to advance understanding of Alzheimer’s disease and Alzheimer’s disease-related dementias (AD+ADRD). In support of the Duke/UNC ADRC and the broader dementia research community, the Core will offer two essential functions: integrated data management and statistical/ bioinformatics collaborative expertise. Building on strong infrastructure at Duke and UNC, the Core proposes the following Specific Aims: 1) Provide coordinated and integrated data management capabilities across the Duke/UNC ADRC to allow easy access, tracking, and reporting capabilities for all of the Cores; 2) Provide datasets to the National Alzheimer’s Disease Coordinating Center (NACC), to other collaborative efforts in Alzheimer’s disease discovery and prevention, and to AD+ADRD investigators at Duke/UNC; 3) Provide statistical/bioinformatics design and analysis consultation; 4) Develop statistical/bioinformatics methods to meet the needs of the ADRC and AD+ADRD research community; and 5) Provide educational opportunities and mentoring of investigators, trainees and junior faculty in collaboration with the Research Education Component on statistical and bioinformatics methodologies for AD+ADRD research. The Core’s combination of state-of-the-art, integrated data management applications and comprehensive statistical expertise enable the creation and expansion of high-impact research initiatives at the ADRC, including innovative multimodal research projects pursuing identification of age-related drivers of AD through genetics, metabolomics, gerontology, and neuroimaging.

摘要-数据管理和统计核心 杜克/杜克阿尔茨海默病研究中心（ADRC）数据管理和统计核心提供了 为促进对阿尔茨海默病和阿尔茨海默病相关痴呆症的了解提供必要的支持 (AD+ ADRD）。为了支持杜克/杜克ADRC和更广泛的痴呆症研究社区，核心将 提供两个基本功能：综合数据管理和统计/生物信息学协作专门知识。 在杜克和杜克大学强大的基础设施的基础上，核心提出了以下具体目标：1）提供 协调和集成整个杜克/杜克大学ADRC的数据管理能力，以方便访问， 所有核心的跟踪和报告能力; 2）向国家阿尔茨海默病中心提供数据集 协调中心（NACC），在阿尔茨海默病的发现和预防的其他合作努力， 为杜克/杜克大学的AD + ADRD研究者提供统计学/生物信息学设计和分析咨询; 4)开发统计/生物信息学方法，以满足ADRC和AD + ADRD研究的需求 社区;以及5）为研究人员、受训人员和初级教员提供教育机会和指导 与研究教育部分合作，就统计和生物信息学方法进行研究， AD + ADRD研究。Core将最先进的集成数据管理应用程序和 全面的统计专业知识，使高影响力的研究倡议的创造和扩大， ADRC，包括创新的多模式研究项目，旨在识别与年龄相关的AD驱动因素 通过遗传学、代谢组学、老年学和神经影像学。