The Oxford Nerve Conduit

牛津神经导管

• 批准号: 10090952
• 金额: $ 269.68万
• 依托单位: NEWROTEX LIMITED
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10090952
• 关键词: Oxford; Nerve; Conduit

Peripheral Nerve Injury (PNI) refers to damage or crushing of nerves outside of the brain or spinal cord, caused by trauma, surgery or cancer. These nerves are responsible for maintaining muscle control & sensations & their damage leads to loss of sensation, chronic pain & loss of muscle movement, reducing patient's quality of life. When nerves are severed, they require surgical intervention to heal. Over 1/2 million patients undergo surgery for PNI in the EU every year The gold standard treatment "autograft", sacrifices another nerve from the patient to act as a donor, causing further harm. This technique is ineffective over large gaps & cannot assure full recovery, with outcomes generally poor (<50% regaining good to excellent motor or sensory function, and 8-12% requiring revision). Moreover, the mean age of patients suffering from these injuries is 32, many of whom then endure lifelong disability due to this condition. The economic burden for each patient (EU) for acute treatment is estimated to be around €139k.

周围神经损伤（PNI）是指由创伤、手术或癌症引起的脑或脊髓外神经的损伤或压碎。这些神经负责维持肌肉控制和感觉，它们的损伤会导致感觉丧失、慢性疼痛和肌肉运动丧失，降低患者的生活质量。当神经被切断时，它们需要手术干预来愈合。在欧盟，每年有超过1/5万的患者接受PNI手术。金标准治疗“自体移植”，牺牲患者的另一根神经作为供体，造成进一步的伤害。这种技术在大间隙上无效，并且不能确保完全恢复，结果通常很差（<50%恢复良好到优秀的运动或感觉功能，8-12%需要翻修）。此外，遭受这些伤害的患者的平均年龄为32岁，其中许多人因这种情况而终身残疾。每例患者（EU）急性治疗的经济负担估计约为13.9万欧元。