BLRD Research Career Scientist Award Application

BLRD 研究职业科学家奖申请

• 批准号: 10481383
• 负责人: KAMAL RAHMOUNI
• 金额: --
• 依托单位: IOWA CITY VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10481383
• 关键词: Autonomic nervous system; Award; Blood Pressure; Body Weight; Brain; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Caring; Cell physiology; Clinical; Clinical Treatment; Collaborations; Communities; Community Participation; Complex; Development; Disease; Doctor of Philosophy; Eating; Educational process of instructing; Energy Metabolism; Ensure; Etiology; Event; FRAP1 gene; Future; Genes; Genetic Transcription; Health; High Prevalence; Homeostasis; Hormones; Human; Hyperphagia; Hypertension; Hypothalamic structure; International; Iowa; Knowledge; Laboratories; Lead; Leptin resistance; Mediating; Medical; Mentors; Metabolic; Metabolic Diseases; Metabolism; Methods; Molecular; Molecular Genetics; Molecular Target; Morbidity - disease rate; Mutation; Nerve; Neurons; Nutrient; Obesity; Obesity associated disease; Pathway interactions; Patients; Peripheral; Physiological; Physiological Processes; Population; Process; Proteins; Regulation; Research; Research Personnel; Risk; Role; Running; Scientist; Signal Pathway; Signal Transduction; Tissues; Training; Universities; Veterans; Work; blood pressure control; cardiovascular risk factor; career; disorder prevention; effective therapy; improved; insight; interdisciplinary approach; leptin receptor; military veteran; mortality; mouse model; neuronal circuitry; neuronal excitability; neuroregulation; next generation; novel; novel therapeutic intervention; obesity development; obesity treatment; programs; protein complex; receptor; response; service organization; tool; trafficking

The applicant is a PhD basic scientist who runs a research program aimed at understanding how the autonomic, metabolism and cardiovascular functions are regulated. I am especially focused on identifying the cellular and molecular processes and circuits that underlie the control of the autonomic nervous system activity, energy homeostasis and blood pressure by the brain. Studies in the laboratory are also directed towards uncovering how these pathways and neuronal circuits are dysregulated in disease conditions such as obesity and hypertension, which are major causes of morbidity and mortality in the VA population. Detailed understanding of the processes involved in metabolic and cardiovascular regulation in health and disease is necessary to develop new treatments for complex disorders such obesity and associated diseases. We plan to build on our previous work to extend our studies to identify new molecular and neuronal processes underlying metabolic and cardiovascular regulation and their pathophysiological role in obesity. We will focus on understanding the mechanisms mediating autonomic, metabolic and cardiovascular control by mTORC1 signaling. We will also investigate the mechanisms involved in autonomic, metabolic and cardiovascular regulation by a protein complex called the BBSome. New insights into the physiological and pathophysiological role of mTORC1 and the BBSome will inform the feasibility of targeting these molecular mechanisms for the treatment of obesity and hypertension. I will also continue training the next generation of biomedical researchers by mentoring and guiding young scientists, both basic and clinical, to maximize their career potential as biomedical investigators. This is crucial to ensure a bright future for medical advances that can improve the health and lives of the Veterans. In addition, I will continue my commitment to serve the VA, affiliated University of Iowa, and the national and international scientific community by participation in teaching, committee service, and organization of research initiatives and events.

申请人是一名博士基础科学家，他正在开展一项研究计划，旨在了解 调节自主神经、新陈代谢和心血管功能。我特别关注 识别细胞和分子的过程和电路的自主控制的基础 神经系统活动、能量稳态和血压。的研究 实验室还致力于揭示这些通路和神经元回路是如何 在疾病状况如肥胖和高血压中失调，这是肥胖和高血压的主要原因。 VA人群的发病率和死亡率。详细了解所涉及的过程， 代谢和心血管调节在健康和疾病是必要的，以开发新的 治疗复杂的疾病，如肥胖症和相关疾病。我们计划建立在我们的 以前的工作，以扩大我们的研究，以确定新的分子和神经元的过程， 代谢和心血管调节及其在肥胖症中的病理生理作用。我们将专注于 了解调节自主神经，代谢和心血管控制的机制， mTORC1信号传导。我们还将研究参与自主神经，代谢和 一种叫做BBSome的蛋白质复合物对心血管的调节作用。新的见解的 mTORC1和BBSome的生理和病理生理作用将为以下方法的可行性提供信息： 针对这些分子机制治疗肥胖和高血压。我也会 通过指导和指导年轻人，继续培养下一代生物医学研究人员 科学家，包括基础和临床，以最大限度地发挥其作为生物医学研究人员的职业潜力。这 对于确保医学进步的光明未来至关重要，这些进步可以改善人们的健康和生活， 老兵此外，我将继续我的承诺，为退伍军人事务部，附属大学爱荷华州， 通过参与教学，委员会服务， 组织研究活动和活动。