Personalized Mobile Intervention to Reduce Exposure to Endocrine Disrupting Chemicals (EDCs) in Women of Child-Bearing Age and their Partners

项目摘要/摘要 接触内分泌干扰物(EDCs)与慢性疾病和 这些疾病包括乳腺癌、代谢综合征、糖尿病和不孕不育。曝光的时机，特别是 在怀孕期间，可能会对胎儿产生终身影响，包括神经发育问题和 哮喘。然而，目前还没有工具来允许那些有成见、受孕和怀孕的人 评估EDC暴露的各个阶段，以确保健康的怀孕和正常的儿童发育。 百万Marker(MM)就是为了满足这一需求而诞生的。MM是一家精准健康公司，由一支 受过环境流行病学、毒理学、分析化学、 生物统计学、数据工程和商业。我们的使命是众包和规模的生物监测 环境化学品，并及时向消费者提供可操作的结果，以赋能 积极主动地评估、跟踪和减少其有害环境暴露。从几个开始 常见内分泌细胞的生物标记物，我们的最终愿景是发现所有可能的(“一百万”)有害的生物标记物 暴露以告知和改善个人健康结果，并推进精准医学。 成立不到一年，百万市场开发并销售了我们的第一个产品-邮寄 尿液双酚A和邻苯二甲酸盐测试-并成功地通过个性化帮助用户减少接触 干预计划。客户可以在线订购检测试剂盒，通过邮寄收到检测试剂盒， 全面的暴露调查(通过Million Marker应用程序)，通过邮件寄回他们的样本，查看他们的 通过安全的在线门户提供个性化的报告和定制的产品推荐，打造生活方式 改变以减少他们的暴露，并重新测试以监测他们的进展。我们最初的目标受众是 生殖年龄的人，由于易怀孕和先入为主的EDC暴露。 然而，目前还不清楚MM平台在多大程度上教育、激励并最终减少了EDC 暴露在这个年龄段的个人身上。 因此，当前提案的目的是：1)测试和验证这种首创的移动EDC 前瞻性纵向队列干预试验中的减量计划；2)评估参与者 使用MM产品和服务后的环境健康素养、态度、知识和行为；以及 3)评估MM APP和平台可用性，提升用户体验。通过以下方式验证此人口 我们的计划是迈向这些类型的未来研究的一步。在项目结束时，我们将 准备好开始第二阶段，并将扩大EDC测试和个性化干预计划以实现生育 诊所和普通民众。

Project Summary/Abstract Exposures to endocrine disrupting chemicals (EDCs) have been linked to chronic diseases and conditions including breast cancer, metabolic syndrome, diabetes, and infertility. Timing of exposure, especially during pregnancy, may have a lifelong impact on the fetus, including neurodevelopmental problems and asthma. However, there have been no tools to allow those in the preconception, conception, and pregnancy stages to assess EDC exposures to ensure a healthy pregnancy and normal child development. Million Marker (MM) was born to fill this need. MM is a precision health company, built by a team of multidisciplinary scientists who are trained in environmental epidemiology, toxicology, analytical chemistry, biostatistics, data engineering, and business. Our missions are to crowdsource and scale the biomonitoring of environmental chemicals and provide actionable results to consumers in a timely manner in order to empower individuals to proactively assess, track, and reduce their harmful environmental exposures. Starting with a few biomarkers of common EDCs, our ultimate vision is to discover all possible (“a million”) biomarkers of harmful exposures to inform and improve individual health outcomes and advance precision medicine. Less than a year after it was founded, Million Marker developed and sold our first product–a mail-in urine test for BPA and phthalates–and successfully helped users reduce their exposures through personalized intervention plans. Customers are able to order a test kit online, receive the test kit via mail, take a comprehensive exposure survey (via the Million Marker app), send back their samples via mail, view their personalized reports with tailored product recommendations through a secure online portal, make lifestyle changes to reduce their exposures, and retest to monitor their progress. Our initial target audience are individuals of reproductive age, due to the vulnerability pregnancy and preconception to EDC exposures. However, it is unclear to what extent the MM platform educates, motivates, and ultimately reduces EDC exposure in individuals in this age range. Therefore, the aims of the current proposal are to 1) test and validate a this first-of-its-kind mobile EDC reduction program in a prospective longitudinal cohort intervention trial; 2) assess changes in participants’ environmental health literacy, attitudes, knowledge, and behaviors after using MM’s products and services; and 3) evaluate the MM app and platform usability to improve the user experience. Validating this population with our program is a step towards these types of future studies. At the conclusion of the project, we will be well-positioned to begin Phase II and will scale the EDCs testing and personalized intervention plan to fertility clinics and the general public.