Personalized Mobile Intervention to Reduce Exposure to Endocrine Disrupting Chemicals (EDCs) in Women of Child-Bearing Age and their Partners

项目总结/摘要 暴露于内分泌干扰化学品（EDCs）与慢性疾病有关， 包括乳腺癌、代谢综合征、糖尿病和不孕症的病症。暴露的时间，特别是 在怀孕期间，可能会对胎儿产生终身影响，包括神经发育问题， 哮喘然而，还没有工具让那些在孕前、怀孕和怀孕期间的人 阶段评估EDC暴露，以确保健康的妊娠和正常的儿童发育。 Million Marker（MM）就是为了满足这一需求而诞生的。MM是一家精密健康公司，由一个团队建立， 受过环境流行病学、毒理学、分析化学、 生物统计学、数据工程和商业。我们的任务是众包和规模的生物监测， 环境化学品，并及时向消费者提供可操作的结果， 个人主动评估，跟踪和减少他们的有害环境暴露。从几个开始 我们的最终愿景是发现所有可能的（“一百万”）有害的生物标志物。 暴露，以告知和改善个人健康结果，并推进精准医疗。 成立不到一年，Million Marker就开发并销售了我们的第一个产品--一个邮件 BPA和邻苯二甲酸盐的尿液测试，并成功地帮助用户减少他们的接触， 干预计划。客户可以在线订购测试套件，通过邮件接收测试套件， 全面的暴露调查（通过百万标记应用程序），通过邮件发回他们的样本，查看他们的 通过安全的在线门户网站提供个性化的报告和定制的产品建议， 改变以减少其暴露，并重新测试以监测其进展。我们最初的目标受众是 生育年龄的个体，由于易怀孕和对EDC暴露的偏见。 然而，目前尚不清楚MM平台在多大程度上教育、激励并最终减少EDC 在这个年龄段的人群中。 因此，当前提案的目的是：1）测试和验证这种首创的移动的EDC 在前瞻性纵向队列干预试验中的减少计划; 2）评估参与者 使用MM产品和服务后的环境健康素养、态度、知识和行为;以及 3)评估MM应用程序和平台的可用性，以改善用户体验。验证此总体， 我们的计划是朝着未来这类研究迈出的一步。在项目结束时，我们将 准备好开始第二阶段，并将扩大EDCs测试和个性化干预计划，以生育 诊所和公众。

Project Summary/Abstract Exposures to endocrine disrupting chemicals (EDCs) have been linked to chronic diseases and conditions including breast cancer, metabolic syndrome, diabetes, and infertility. Timing of exposure, especially during pregnancy, may have a lifelong impact on the fetus, including neurodevelopmental problems and asthma. However, there have been no tools to allow those in the preconception, conception, and pregnancy stages to assess EDC exposures to ensure a healthy pregnancy and normal child development. Million Marker (MM) was born to fill this need. MM is a precision health company, built by a team of multidisciplinary scientists who are trained in environmental epidemiology, toxicology, analytical chemistry, biostatistics, data engineering, and business. Our missions are to crowdsource and scale the biomonitoring of environmental chemicals and provide actionable results to consumers in a timely manner in order to empower individuals to proactively assess, track, and reduce their harmful environmental exposures. Starting with a few biomarkers of common EDCs, our ultimate vision is to discover all possible (“a million”) biomarkers of harmful exposures to inform and improve individual health outcomes and advance precision medicine. Less than a year after it was founded, Million Marker developed and sold our first product–a mail-in urine test for BPA and phthalates–and successfully helped users reduce their exposures through personalized intervention plans. Customers are able to order a test kit online, receive the test kit via mail, take a comprehensive exposure survey (via the Million Marker app), send back their samples via mail, view their personalized reports with tailored product recommendations through a secure online portal, make lifestyle changes to reduce their exposures, and retest to monitor their progress. Our initial target audience are individuals of reproductive age, due to the vulnerability pregnancy and preconception to EDC exposures. However, it is unclear to what extent the MM platform educates, motivates, and ultimately reduces EDC exposure in individuals in this age range. Therefore, the aims of the current proposal are to 1) test and validate a this first-of-its-kind mobile EDC reduction program in a prospective longitudinal cohort intervention trial; 2) assess changes in participants’ environmental health literacy, attitudes, knowledge, and behaviors after using MM’s products and services; and 3) evaluate the MM app and platform usability to improve the user experience. Validating this population with our program is a step towards these types of future studies. At the conclusion of the project, we will be well-positioned to begin Phase II and will scale the EDCs testing and personalized intervention plan to fertility clinics and the general public.