Pesticide exposures, mental health and endocrine disruption among children growing up near pesticide spray sites.

在农药喷洒点附近长大的儿童的农药接触、心理健康和内分泌紊乱。

基本信息

  • 批准号:
    10482338
  • 负责人:
  • 金额:
    $ 16.32万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-21 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

Pesticides pose a public health risk to children living in agricultural communities. Children are particularly vulnerable to the chronic effects of environmental contaminants such as insecticides, due to their size, physiology and behavior. Worldwide, the two most widely used classes of insecticides are cholinesterase inhibitors (organophosphates) and neonicotinoids. While some of the risks of organophosphates are known, to date, there are no longitudinal studies of neurobehavioral or mental health outcomes in adolescents related to spatial patterns of exposure to organophosphates and neonicotinoids. There is also no known research on the associated neurobehavioral health alterations from neonicotinoid exposures in drinking or irrigation water. The proposed study will leverage the parent, NIEHS-funded, longitudinal study of Secondary Pesticide Exposures among Children and Adolescents (ESPINA), that examined 313 children (4-6 years old) in 2008, who live near one of the highest concentrations of floriculture in the Americas, 535 adolescents in 2016, and is planning for a subsequent examination in 2020. The proposed K01 will integrate biological monitoring, household survey, and neurobehavioral examination data and utilize geospatial models and complex statistical techniques to: (1) disentangle pathways of pesticide exposure, (2) study the geospatial determinants of neurobehavioral performance (attention, memory, language, sensorimotor and visuospatial) and outcomes (anxiety and depression) in children and adolescents from pesticide exposure, (3) test pesticide exposure in drinking water and irrigation sources in proximity to floriculture. This is an application for a NIEHS Transition to Independent Environmental Health Research (TIEHR) Career Award for Dr. Georgia Kayser, an early career Environmental Health Assistant Professor in the Department of Family Medicine and Public Health in the School of Medicine at the University of California, San Diego. Dr. Kayser aims to establish herself as an independent environmental health investigator in the areas of pesticide exposure in children and adolescents and associated neurobehavioral outcomes and expand her water and health research to include pesticides in drinking and irrigation water. The award will provide Dr. Kayser with the support to achieve her career development goals: (1) to develop advanced methodological skills in biostatistics and geospatial analysis; (2) to advance training on child development and the interpretation and analysis of neurobehavioral assessment; (3) to acquire skills in spatiotemporal analysis of pesticide exposure data and neurobehavioral outcomes, (4) identify points of intervention and prevention to reduce pesticide exposure in children living in agricultural areas, (5) gain independence. The research and training activities outlined here will generate new research to inform the design of an intervention to be evaluated in an R01, and the application will be completed in year three of this award. This award will also build a strong research network between the United States (USCD) and Ecuador (USFQ).
农药对生活在农业社区的儿童构成公共健康风险。儿童尤其如此

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Georgia L. Kayser其他文献

Rural Water Point Functionality Estimates and Associations: Evidence From Nine Countries in Sub‐Saharan Africa and South Asia
农村水点功能估计和关联:来自撒哈拉以南非洲和南亚九个国家的证据
  • DOI:
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    5.4
  • 作者:
    Anna L. Murray;Gabriela Stone;Audrey R. Yang;Nicholas F. Lawrence;Hannah Matthews;Georgia L. Kayser
  • 通讯作者:
    Georgia L. Kayser
Predictors of household drinking water <em>E. coli</em> contamination: Population-based results from rural areas of Ghana, Malawi, Mozambique, Niger, Rwanda, Uganda, and Zambia
  • DOI:
    10.1016/j.ijheh.2024.114507
  • 发表时间:
    2025-03-01
  • 期刊:
  • 影响因子:
  • 作者:
    Audrey R. Yang;James M. Bowling;Camille E. Morgan;Jamie Bartram;Georgia L. Kayser
  • 通讯作者:
    Georgia L. Kayser
Drinking water and the implications for gender equity and empowerment: A systematic review of qualitative and quantitative evidence
饮用水与性别平等和赋权的影响:定性和定量证据的系统评价
  • DOI:
    10.1016/j.ijheh.2022.114044
  • 发表时间:
    2023-01-01
  • 期刊:
  • 影响因子:
    4.400
  • 作者:
    Kimberly De Guzman;Gabriela Stone;Audrey R. Yang;Kristen E. Schaffer;Shelton Lo;Rola Kojok;Colette R. Kirkpatrick;Ada G. Del Pozo;Tina T. Le;Lindsey DePledge;Elizabeth L. Frost;Georgia L. Kayser
  • 通讯作者:
    Georgia L. Kayser
Relationships of residential distance to greenhouse floriculture and organophosphate, pyrethroid, and neonicotinoid urinary metabolite concentration in Ecuadorian Adolescents
  • DOI:
    10.1186/s12942-025-00395-w
  • 发表时间:
    2025-04-18
  • 期刊:
  • 影响因子:
    3.200
  • 作者:
    Briana N. C. Chronister;Georgia L. Kayser;Franklin de la Cruz;Jose Suarez-Torres;Dolores Lopez-Paredes;Sheila Gahagan;Harvey Checkoway;Marta M. Jankowska;Jose R. Suarez-Lopez
  • 通讯作者:
    Jose R. Suarez-Lopez

Georgia L. Kayser的其他文献

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{{ truncateString('Georgia L. Kayser', 18)}}的其他基金

Pesticide exposures, mental health and endocrine disruption among children growing up near pesticide spray sites.
在农药喷洒点附近长大的儿童的农药接触、心理健康和内分泌紊乱。
  • 批准号:
    10820052
  • 财政年份:
    2020
  • 资助金额:
    $ 16.32万
  • 项目类别:
Pesticide exposures, mental health and endocrine disruption among children growing up near pesticide spray sites.
在农药喷洒点附近长大的儿童的农药接触、心理健康和内分泌紊乱。
  • 批准号:
    10267166
  • 财政年份:
    2020
  • 资助金额:
    $ 16.32万
  • 项目类别:

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