CORE C: DMSC Core

核心 C:DMSC 核心

基本信息

  • 批准号:
    10482394
  • 负责人:
  • 金额:
    $ 29.51万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-09-01 至 2026-06-30
  • 项目状态:
    未结题

项目摘要

SUMMARY/ABSTRACT Data Management and Statistics Core (DMSC) The Data Management and Statistics Core (DMSC) is an integral component of the Center for Neurodegeneration and Translational Neuroscience (CNTN), providing each project and core with the digital infrastructure for accurate data capture, secure storage, access to high-quality integrated datasets, and expert statistical consultation. Through these resources, the DMSC directly facilitates the CNTN goals of advancing the careers of junior investigators, expanding the neuroscience and research infrastructure in Nevada, and enhancing the understanding of neurodegenerative diseases (NDD). In Phase 1 of the COBRE award, the DMSC adopted OpenClinica, an open-sourced electronic data capture platform, to construct a distributed cloud- based data entry system that is 21 CFR Part 11 compliant. Throughout Phase 1, the Clinical and Translational Research Core (CTRC) of the CNTN established a cohort of individuals with AD or PD, and a group of demographically comparable cognitively normal (CN) older adults. A comprehensive data set generated by the CTRC, captured using OpenClinica, and maintained by the DMSC serves as a gateway for NDD researchers and collaborators who are not project leaders. Given the growth of the DMSC under the leadership of Joseph Lombardo in Phase 1, we intend to expand this Core during Phase 2. Director Lombardo will continue to lead the Core. Guogen Shan, PhD will serve as Associate Director for Biostatistics and will continue to work with COBRE and non-COBRE researchers to develop novel statistical tools to analyze neuroscience data. Justin B. Miller, PhD, a neuropsychologist with a deep interest in biomedical informatics, will be the Associate Director for Biomedical Informatics for Phase 2. During Phase 1 of the award, Dr. Miller worked under the mentorship of Gustavo Jiminez-Maggoria, Director of Informatics at the University of Southern California’s Alzheimer’s Therapeutic Research Institute, and has functioned as a liaison between DMSC faculty, the CTRC, and project leaders to ensure that the database functions smoothly for comprehensive data capture, organization, archiving, analysis, and export to non-COBRE research communities. In Phase 2 of the award, Dr. Miller will continue to work with project leaders and core directors to ensure that study data are of good quality, readily available, and accessible to project leaders. Additionally, in Phase 2, members of the DMSC will work extensively with the newly formed and recently integrated Brain Imaging Core (BIC). Phase 2 will require expansion and refinement of the DMSC’s digital infrastructure to facilitate integration of both raw image data and structured quantitative imaging data.
总结/摘要 数据管理和统计核心(DMSC) 数据管理和统计核心(DMSC)是中心的一个组成部分, 神经退行性疾病和转化神经科学(CNTN),为每个项目和核心提供数字 用于准确数据捕获、安全存储、访问高质量集成数据集和专家 统计咨询。通过这些资源,DMSC直接促进了CNTN推进 初级研究人员的职业生涯,扩大内华达州的神经科学和研究基础设施, 提高对神经退行性疾病(NDD)的认识。在COBRE奖的第一阶段, DMSC采用开源电子数据采集平台OpenClinica构建分布式云- 符合21 CFR Part 11标准的数据输入系统。在整个第1阶段,临床和转化 CNTN的研究核心(CTRC)建立了一组AD或PD患者,以及一组 在人口统计学上具有可比性的认知正常(CN)老年人。一个综合的数据集, 使用OpenClinica捕获并由DMSC维护的CTRC是NDD研究人员的网关 和非项目负责人的合作者。鉴于DMSC在约瑟夫的领导下发展壮大, Lombardo在第一阶段,我们打算在第二阶段扩大这一核心。伦巴多局长将继续领导 核心的Guogen Shan博士将担任生物统计学副主任,并将继续与 COBRE和非COBRE研究人员开发新的统计工具来分析神经科学数据。贾斯汀B。 米勒,博士,神经心理学家与生物医学信息学的浓厚兴趣,将是副主任 生物医学信息学第二阶段。在该奖项的第一阶段,米勒博士在以下指导下工作: Gustavo Jiminez-Maggoria,南加州大学老年痴呆症信息学主任 治疗研究所,并作为DMSC教师,CTRC和项目之间的联络人 领导者确保数据库顺利运行,以进行全面的数据采集、组织、存档, 分析,并输出到非COBRE研究社区。在该奖项的第二阶段,米勒博士将继续 与项目负责人和核心负责人合作,确保研究数据质量良好,随时可用, 对项目负责人开放。此外,在第二阶段,DMSC成员将与 新成立和最近整合的脑成像核心(BIC)。第二阶段将需要扩大和完善 DMSC的数字基础设施,以促进原始图像数据和结构化定量 成像数据。

项目成果

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