Building Capacity to study mixed metal-induced neurotoxicity in rural Bangladeshi children-A1

孟加拉国农村儿童研究混合金属引起的神经毒性的能力建设-A1

基本信息

  • 批准号:
    10488220
  • 负责人:
  • 金额:
    $ 53.75万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-14 至 2026-06-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY The economic and public health burden of neurological diseases are remarkably high in Bangladesh with 5,344 cases per 100,000 people. Yet, the etiology of neurological disorders with respect to environmental pollutants, particularly toxic metals such as arsenic (As), lead (Pb), manganese (Mn), and cadmium (Cd), is poorly understood. These metals co-exist at moderate to high levels posing additional risk to children. Recent Bangladesh studies, including our own, have shown neurobehavioral (NB) effects associated with single metal exposure in children living in the rural areas. These detrimental effects, often subtle, potentially have long-term impact on the educational, social, and economic development of the population. This is, in part, due to the limited research capacity of local Bangladeshi researchers to properly evaluate the impact of mixed metal-induced impairment on brain function. To address this fundamental gap in critical research capacity, we plan to improve the research skills of Bangladeshi scientists by providing them the necessary training to appropriately investigate children’s brain vulnerability induced by metal co-exposure. The proposed study has assembled a group of U.S. investigators from Sam Houston State University, Columbia University, the University of Houston, Baylor College of Medicine, and the University of Iowa. The U.S. scientists will collaborate with the Bangladeshi researchers and faculty from the International Center for Diarrheal Disease Research, Bangladesh (icddr,b), Bangabandhu Sheikh Mujib Medical University (BSMMU), the largest medical university in Bangladesh, and North South University (NSU). Our goal is to improve the research capacity of scientists and clinicians by (i) organizing in-country and virtual yearly workshops/training and symposia on neuro-epidemiological research methodology and manuscript preparation; (ii) providing within the U.S. (and virtually), training on various neurobehavioral (NB) evaluation tools and data analysis; and (iii) involving the local researchers in two proposed epidemiological studies to be conducted in Bangladesh. In the first study, 600 adolescents from the Health Effects of Arsenic Longitudinal Study (HEALS) cohort in Araihazar will be evaluated for NB performance. Concurrently, adolescent blood samples will be analyzed for metals and thyroid hormone (TH) since metals are known to disrupt TH prenatally leading to poor NB performance in childhood. Free thyroxine (fT4), total triiodothyronine (tT3), thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) will be analyzed. The Behavioral Assessment and Research System (BARS) battery will be used for NB assessment. The second study will recruit 200 mother-child pairs from the Health and Demographic Surveillance System (HDSS) area in Matlab to assess if maternal metal mixture exposure is associated with TH disruption in early pregnancy, and in turn, if prenatal disruption of TH interferes with NB performance in young children. Together, these two studies will test if metal- induced neurotoxicity in early life, in part, mediate the relationships between metal co-exposure and NB.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Khalid M. Khan其他文献

4-Arylamino-6-nitroquinazolines: Synthesis and their activities against neglected disease leishmaniasis.
4-芳氨基-6-硝基喹唑啉:合成及其对抗被忽视的疾病利什曼病的活性。
Synthesis, Characterization, and Biological Activity of n-Tributyltin Derivatives of Pharmaceutically Active Carboxylates
  • DOI:
    10.1007/s007060200079
  • 发表时间:
    2002-08-01
  • 期刊:
  • 影响因子:
    1.900
  • 作者:
    Saira Shahzadi;Moazzam H. Bhatti;Khadija Shahid;Saqib Ali;Saadia R. Tariq;Mohammad Mazhar;Khalid M. Khan
  • 通讯作者:
    Khalid M. Khan
Isatin thiazoles as antidiabetic: Synthesis, in vitro enzyme inhibitory activities, kinetics, and in silico studies
靛红噻唑作为抗糖尿病药:合成、体外酶抑制活性、动力学和计算机研究
  • DOI:
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    5.1
  • 作者:
    Mehwish Solangi;Kanwal;Khalid M. Khan;S. Chigurupati;F. Saleem;Urooj Qureshi;Zaheer Ul;A. Jabeen;S. G. Felemban;Fatima Zafar;S. Perveen;M. Taha;S. Bhatia
  • 通讯作者:
    S. Bhatia
Synthesis and Biological Evaluation of Isomeric Derivatives of Naturally Occurring Spatozoate
天然 Spatozoate 异构衍生物的合成和生物学评价
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    S. Hayat;A. Atta;M. Choudhary;Khalid M. Khan;S. Perveen;S. Shah;Awais Anwar;M. U. Anwar;E. Bayer;W. Voelter
  • 通讯作者:
    W. Voelter
Structural mass irregularities and fiber volume influence on morphology and mechanical properties of unsaturated polyester resin in matrix composites
  • DOI:
    10.1016/j.jare.2014.06.007
  • 发表时间:
    2015-11-01
  • 期刊:
  • 影响因子:
  • 作者:
    Khalil Ahmed;Muhammad Nasir;Nasreen Fatima;Khalid M. Khan;Durey N. Zahra
  • 通讯作者:
    Durey N. Zahra

Khalid M. Khan的其他文献

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{{ truncateString('Khalid M. Khan', 18)}}的其他基金

Building Capacity to study mixed metal-induced neurotoxicity in rural Bangladeshi children-A1
孟加拉国农村儿童研究混合金属引起的神经毒性的能力建设-A1
  • 批准号:
    10656538
  • 财政年份:
    2021
  • 资助金额:
    $ 53.75万
  • 项目类别:
Building Capacity to study mixed metal-induced neurotoxicity in rural Bangladeshi children-A1
孟加拉国农村儿童研究混合金属引起的神经毒性的能力建设-A1
  • 批准号:
    10299709
  • 财政年份:
    2021
  • 资助金额:
    $ 53.75万
  • 项目类别:

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