ASSAY DEVELOPMENT CONSULTING SERVICES FOR NINDS' HEAL PROGRAM

NINDS HEAL 计划的检测开发咨询服务

• 批准号: 10497994
• 负责人: LISA MINOR
• 金额: $ 1.08万
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-24 至 2022-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10497994
• 关键词: Address; Biochemical; Biological Assay; Cells; Chronic; Clinical; Clinical Research; Consult; Consultations; Contractor; Development; Helping to End Addiction Long-term; Individual; Knee Osteoarthritis; Logistics; National Institute of Neurological Disorders and Stroke; Opiate Addiction; Pain; Pain management; Perioperative; Pharmaceutical Chemistry; Quality of life; Resources; Role; Services; Speed; Strategic Planning; United States National Institutes of Health; Validation; assay development; base; chronic musculoskeletal pain; clinical pain; design; drug development; experimental study; improved; in vitro Assay; lead optimization; novel; pre-clinical; programs; small molecule

1. Bioactivity Assay Bioactivity Assay consultants may be required to evaluate bioactivity assays and recommend strategies and experiments to optimize and/or validate the assays for use in a medicinal chemistry campaign. Bioactivity Assay consultants may be asked to assist in the establishment of milestones related to assay optimization or validation. The NIH may seek guidance from consultants on the design and interpretation of commonly used in vitro assays, such as biochemical and cell-based assays. Specific consulting responsibilities will depend on the expertise of the individual consultant and the needs of individual projects. Assay-related consultation services may be required on an ad hoc basis or on LDTs. The role of the Bioactivity Assay consultant may include but is not limited to the following responsibilities and tasks: • In partnership with other consultants, contractors, and NIH staff, advise, strategically plan, and manage programs to facilitate lead optimization, INDenabling studies, and clinical studies. • Serve as a resource to LDT for assay requirements and logistics to conduct drug development activities for small molecule compounds from the preclinical stage through to the initial clinical stage • Serve as the assay expert in order to identify potential developmental challenges and suggest strategies to address these challenges. • Collaborate on design of investigative studies in support of development compounds. This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to understand the basis of pain and enhance clinical pain management. It’s part of the program that establishes novel treatment options for a variety of pain conditions to improve quality of life and reduce opioid dependency. The program studies a broad range of pain conditions, including chronic overlapping pain conditions, chronic musculoskeletal pain, perioperative pain, and knee osteoarthritis.

1. 生物活性测定 可能需要生物活性测定顾问来评估生物活性测定和 推荐策略和实验来优化和/或验证用于 药物化学运动。可能会要求生物活性测定顾问协助 建立与测定优化或验证相关的里程碑。美国国立卫生研究院可能 寻求顾问对常用的设计和解释的指导 体外测定，例如生化和细胞测定。具体咨询 职责将取决于个人顾问的专业知识和需求 个人项目。可能会临时需要与化验相关的咨询服务 或基于LDT。 生物活性测定顾问的角色可能包括但不限于 以下职责和任务： • 与其他顾问、承包商和 NIH 工作人员合作，提出建议， 战略性地规划和管理项目，以促进先导化合物优化、INDenable 研究和临床研究。 • 充当 LDT 的资源，满足检测要求和进行药物的后勤工作 临床前阶段小分子化合物的开发活动 直至初始临床阶段 • 担任检测专家，以确定潜在的发育挑战 并提出应对这些挑战的策略。 • 合作设计调查研究以支持发展 化合物。 这项研究是 NIH 帮助结束成瘾长期 (HEAL) 计划的一部分，旨在加快科学解决方案的速度，以了解疼痛的基础并加强临床疼痛管理。这是该计划的一部分，该计划为各种疼痛状况建立新的治疗方案，以提高生活质量并减少阿片类药物依赖。 该项目研究广泛的疼痛状况，包括慢性重叠疼痛、慢性肌肉骨骼疼痛、围手术期疼痛和膝骨关节炎。