Clinical Core

临床核心

• 批准号: 10495212
• 负责人: STEWART A FACTOR
• 金额: $ 18万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-29 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10495212
• 关键词: Advertising; Affect; Age; Alzheimer' s Disease; Appointment; Behavior; Behavioral; Brain; Clinic; Clinic Visits; Clinical; Clinical Research; Cognitive; Collaborations; Collection; Communication; Computer Models; Data; Data Collection; Databases; Deep Brain Stimulation; Documentation; Electrocorticogram; Electrophysiology (science); Enrollment; Ensure; Evaluation; Functional disorder; Goals; Human Resources; Implant; Implantation procedure; Impulsivity; Individual; Internet; Laboratories; Lead; Logistics; Motor; Neurocognitive; Neuropsychological Tests; Neuropsychology; Operative Surgical Procedures; Outpatients; Parkinson Disease; Participant; Patient Recruitments; Patients; Play; Prefrontal Cortex; Process; Recruitment Activity; Research; Research Activity; Research Personnel; Research Support; Role; Schedule; Series; Services; Signal Transduction; Source; Structure of subthalamic nucleus; Study Subject; Techniques; Test Result; Testing; Travel; Universities; Visit; Work; awake; behavior test; behavioral outcome; clinical center; cognitive change; cognitive testing; cohort; data management; executive function; follow-up; implantation; improved; programs; recruit; response; retention rate; sex; social media

Project Summary – Clinical Core (Core C) The proposed Clinical Core (Core C) will support project 4 of the Emory Udall Center in its studies of the inter- actions between the prefrontal cortex and the subthalamic nucleus (STN) in response inhibition functions in patients with Parkinson’s disease (PD) who undergo deep brain stimulation (DBS) lead implantation procedures targeting the STN. The prefrontal cortex plays a central role in PD-associated cognitive and behavioral changes, particularly in executive functions, such as response inhibition. The Core will provide coordinator services for the project 4 studies. In addition to research activity, documentation of completed assessments, and coordinat- ing the completion of detailed cognitive assessments, the Core focuses on patient recruitment and retention strategies. The Core will leverage the active DBS program at Emory to recruit well-characterized PD patients who are undertaking the DBS selection process (Aim 1), with the goal of recruiting 40 such patients for pre- operative assessments, including detailed neuropsychological testing and motor evaluations in addition to the testing during response inhibition tasks that will be done under project 4. Recruitment activities will include various advertising strategies through flyers distributed in the clinic, web and social media advertising, as well as public presentations. Of the recruited PD patients, 15 will also be tested in the OR during DBS lead implan- tation, and 20 will have a repeat outpatient assessment 6-12 months post-surgery. In addition, the Core will recruit 40 well-characterized age- and sex-matched healthy controls through a collaboration with various existing sources, including the Clinical Core of the Emory Alzheimer’s Disease Research Center (ADRC), and the Emory Healthy Brain Study (Aim 2). These individuals will undergo the same series of tests as the PD cohort at visit 1. To ensure continuity, all neuropsychological assessments will be overseen by one of the Udall Center’s Co-Is who also functions as co-leader of the ADRC clinical core. The Core will communicate the results of individual and group test results to all study participants. Finally, the Core will develop and maintain a REDCap database of data collected in project 4 (Aim 3).

项目摘要-临床核心（核心C）