Clinical Core

项目摘要-临床核心(核心C) 拟议的临床核心(核心C)将支持埃默里·尤德尔中心的项目4，以研究 前额叶皮质和丘脑底核在反应抑制功能中的作用 接受脑深部刺激(DBS)导联植入手术的帕金森病(PD)患者 目标是STN。前额叶皮质在帕金森病相关的认知和行为改变中起着核心作用， 特别是在执行功能方面，如反应抑制。核心将为以下项目提供协调服务 项目4研究。除研究活动外，记录已完成的评估，并协调- 在完成详细的认知评估时，核心重点放在患者招募和留住上 战略。Core将利用Emory的积极DBS计划来招募具有良好特征的PD患者 正在开展DBS遴选程序(目标1)，目标是招募40名此类患者进行预培训 手术评估，包括详细的神经心理测试和运动评估 将在项目4下完成的反应抑制任务期间的测试。招募活动将包括 通过在诊所分发传单、网络和社交媒体广告等多种广告策略 作为公开展示。在招募的PD患者中，15名还将在星展银行领导实施计划期间在OR接受测试- 其中20人将在术后6-12个月进行重复的门诊评估。此外，核心将 通过与现有的各种机构合作，招募40名年龄和性别匹配的健康对照 资料来源，包括埃默里阿尔茨海默病研究中心(ADRC)的临床核心，以及埃默里 健康大脑研究(目标2)。这些人将在探视1接受与PD队列相同的一系列测试。 为了确保连续性，所有神经心理评估将由尤德尔中心的一名协管员监督 世卫组织还担任ADRC临床核心的联合领导人。核心将传达个人的结果 并将团体测试结果通知所有研究参与者。最后，核心将开发和维护一个红帽数据库 项目4(目标3)中收集的数据。

Project Summary – Clinical Core (Core C) The proposed Clinical Core (Core C) will support project 4 of the Emory Udall Center in its studies of the inter- actions between the prefrontal cortex and the subthalamic nucleus (STN) in response inhibition functions in patients with Parkinson’s disease (PD) who undergo deep brain stimulation (DBS) lead implantation procedures targeting the STN. The prefrontal cortex plays a central role in PD-associated cognitive and behavioral changes, particularly in executive functions, such as response inhibition. The Core will provide coordinator services for the project 4 studies. In addition to research activity, documentation of completed assessments, and coordinat- ing the completion of detailed cognitive assessments, the Core focuses on patient recruitment and retention strategies. The Core will leverage the active DBS program at Emory to recruit well-characterized PD patients who are undertaking the DBS selection process (Aim 1), with the goal of recruiting 40 such patients for pre- operative assessments, including detailed neuropsychological testing and motor evaluations in addition to the testing during response inhibition tasks that will be done under project 4. Recruitment activities will include various advertising strategies through flyers distributed in the clinic, web and social media advertising, as well as public presentations. Of the recruited PD patients, 15 will also be tested in the OR during DBS lead implan- tation, and 20 will have a repeat outpatient assessment 6-12 months post-surgery. In addition, the Core will recruit 40 well-characterized age- and sex-matched healthy controls through a collaboration with various existing sources, including the Clinical Core of the Emory Alzheimer’s Disease Research Center (ADRC), and the Emory Healthy Brain Study (Aim 2). These individuals will undergo the same series of tests as the PD cohort at visit 1. To ensure continuity, all neuropsychological assessments will be overseen by one of the Udall Center’s Co-Is who also functions as co-leader of the ADRC clinical core. The Core will communicate the results of individual and group test results to all study participants. Finally, the Core will develop and maintain a REDCap database of data collected in project 4 (Aim 3).