Optimizing Research Methodology in a Multinutrient Study of Racially and Ethnically Diverse Children with ADHD and Emotional Dysregulation

优化针对患有多动症和情绪失调的种族和民族多元化儿童的多营养素研究中的研究方法

• 批准号: 10506799
• 负责人: Jeanette M Johnstone
• 金额: $ 17.49万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-07 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10506799
• 关键词: 12 year old; Academic Medical Centers; Address; Adult; Affect; Anger; Anxiety Disorders; Area; Attention deficit hyperactivity disorder; Award; Behavioral; Biological; Biological Markers; Black race; Blood; Blood capillaries; Caregivers; Caring; Cessation of life; Child; Child Behavior; Child Mental Health; Childhood; Chronic; Clinical Trials; Collection; Communities; Complementary Health; Conduct Clinical Trials; Data; Data Collection; Development; Devices; Diagnosis; Disease; Ecological momentary assessment; Elements; Enrollment; Ensure; Evaluation; Failure; Family; Feasibility Studies; Feedback; Focus Groups; Foundations; Frequencies; Future; Goals; Grant; Health; Health Priorities; Healthcare; Hispanic; Home; Hour; Immune; Impairment; Individual; Integrative Medicine; Intervention; Intervention Studies; Investigation; K-Series Research Career Programs; Leadership; Measures; Mediator of activation protein; Mental Depression; Mental Health; Mental disorders; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; Minerals; Modeling; National Center for Complementary and Integrative Health; Neurodevelopmental Disorder; Neuroimmune; Neuroimmune system; Neurotransmitters; Not Hispanic or Latino; Occupations; Outcome; Parents; Participant; Pathway interactions; Patients; Plasma; Population; Population Heterogeneity; Preparation; Problem behavior; Process; Protocols documentation; Public Health; Randomized Clinical Trials; Randomized Controlled Trials; Recovery; Reporting; Research; Research Design; Research Methodology; Resources; Sampling; Self Administration; Signal Transduction; Specimen; Suicide; Supplementation; Symptoms; Testing; Theoretical model; Time; Training; Urine; Vitamins; Writing; acceptability and feasibility; addiction; base; behavior change; career development; community engagement; cytokine; design; dietary supplements; emotion dysregulation; ethnic diversity; hispanic community; improved; mindfulness; neuroinflammation; novel; open label; patient population; physical conditioning; potential biomarker; premature; programs; public health priorities; racial diversity; recruit; response; sample collection; side effect; skills; standard care; substance misuse

PROJECT SUMMARY This K23 award will solidify the applicant’s capacity to conduct independent patient-focused, multicomponent dietary supplement clinical trials for mental health conditions. This proposal focuses on attention-deficit/hyperactivity disorder (ADHD) in children. ADHD is a central element in an early causal pathway to future depression, anxiety disorders, substance misuse, job and relationship failures, chronic health problems, suicide, and premature death. It is, therefore, a major public health priority. Perhaps the most impairing single feature of ADHD, which cuts across disorders and remains difficult to treat, is extreme emotional dysregulation (anger, moodiness, and irritability). The candidate has conducted clinical trials in children and adults with ADHD and emotional dysregulation that have shown benefit for a multinutrient dietary supplement containing all known vitamins and essential minerals. Limiting the reach and generalizability of this promising intervention, previous studies have included a majority of white, non-Hispanic participants; imprecise behavior change data; and limited examination of the multinutrients’ mechanisms of action. This proposal addresses these key issues. Aim 1 proposes a community-based, qualitative study using focus groups with Black and Hispanic parents to elicit their priorities concerning their child’s mental health and barriers to participation in research. Aims 2 and 3 propose a feasibility and acceptability study (pilot clinical trial) of the intervention in Black and Hispanic children. The study design will be informed by focus group feedback. Aim 2 tests real-time parent-reported behavior change in their child based on a targeted problem identified by the parent. Aim 3 tests the at-home biospecimen collection of blood and urine to initiate an examination of immune and neurotransmitter biomarker signals. Career development areas align closely with the research aims, and include training in community engagement and mixed methods to identify mental health priorities of diverse communities; mediator/moderator models and neuroimmune factors that affect mental health in order to initiate biomarker investigation; and professional development including leadership and grant writing skills. Career development will occur at a resource-rich academic medical center. The application is bolstered by an interdisciplinary mentor team of intellectually, racially, and ethnically diverse individuals. While this proposal focuses on ADHD and emotional dysregulation in children, the applicant’s training and proposal results are expected to generalize to CIH research broadly, as the NCCIH prioritizes increasing research participant diversity and examining biomarkers for mechanistic signals. This K23 will provide the applicant with the training and preliminary data to be competitive for an R01 study of the promising multinutrient intervention using refined data and biospecimen collection methods in a larger, diverse sample while testing biomarker hypotheses, building on the award findings. This application will enable the applicant to advance a larger program of research investigating multicomponent CIH interventions for patient populations with emotional dysregulation across mental health diagnoses.

项目总结