iCARE4CVD - INDIVIDUALISED CARE FROM EARLY RISK OF CARDIOVASCULAR DISEASE TO ESTABLISHED HEART FAILURE

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The burden of cardiovascular disease (CVD) on society is huge with >85 million people affected in Europe. The overall prevalencecontinues to grow due to unhealthy lifestyles and population aging. Heart failure (HF) is the final common pathway of all CVD and hasa 5 year mortality rate of 20-50% despite significant advances in therapy. iCARE4CVD aims to address this burden by contributing tothree essential steps to improve the current care pathways, covering all stages from early risk to established HF: 1) early diagnosis toidentify patients at risk of CVD and divide them into clinically meaningful subgroups; 2) risk stratification for these subgroups to definethe urgency for intervention; and 3) prediction of treatment response for each subgroup. This will be achieved by the following steps:clinical partners will provide a large set of cohorts including >1,000,000 patients with a wide range of biomarkers (e.g. digital, blood,imaging). Anonymous access to data will be enabled by using a blockchain-supported federated database. Artificial intelligence-basedmodeling also considering patient relevant factors will assess changes in risk and stratify patients according to their individual responsesto therapy. Results will then be prospectively validated in new and ongoing large cohorts and a pilot trial to test the prediction of treatmentresponse by using multiple biomarkers going beyond current risk prediction (such as SCORE) towards individualized therapy. Resultswill be used to provide novel decision tools for each step targeting newly identified subgroups and as a blueprint for innovative futuretrials to individualise prevention and therapy. Patient involvement is key in every part of iCARE4CVD (e.g. patient advisory board) tobuild a motivational framework for self-care by patients. The project brings together an EU-wide consortium with the needed resourcesand expertise from the public and private side to bring iCARE4CVD to success