Cell Manipulation Tools

细胞操作工具

• 批准号: 10595864
• 负责人: HANS-PETER KIEM
• 金额: $ 7.4万
• 依托单位: FRED HUTCHINSON CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10595864
• 关键词: Cell; Manipulation; Tools

PROJECT SUMMARY/ABSTRACT - Cell Manipulation Tools Core (Tools) The recent characterization of the human genome combined with powerful new sequence-directed gene manipulation technologies have revolutionized our ability to ask biological questions, identify and manipulate disease causing alterations, and create targeted therapeutics. However, serious barriers still exist for individual researchers attempting to perform and assess genome manipulations. This is particularly true for applications involving human hematopoietic cell products, which require specialized knowledge and functional assays. The mission of the Tools Core is to act as an interface between cutting edge genome manipulation techniques and researchers and clinicians to provide access to protocols, reagents, and consultants for genetic alteration of human and canine hematopoietic cell products. The ultimate goal of the Tools Core is to break down access barriers and provide appropriate infrastructure and support for functional genetic and viral vector technology platforms in hematopoietic cell products. The Tools Core will be directed by Drs. Kiem and Paddison who have outstanding track records in the fields of viral vector-mediated gene therapy, functional genomics, gene editing, vector production, and stem and progenitor cell manipulation. Functions of the Tools Core include provision of reagents for user-performed genome manipulations, best practices protocols, consultations for manipulation of hematopoietic cell products, gene edited cell products, and development of new technology to improve gene editing and viral vector performance.

项目摘要/摘要-细胞操作工具核心（工具）