Cohort Network to be Activated Globally in Outbreaks

CONTAGIO是一个由来自欧洲、北美、拉丁美洲、亚洲和非洲的研究人员组成的联盟，旨在建立协调机制，对低收入和中等收入国家（LMICs）的传染病（再）出现作出快速反应。该联盟以欧盟资助的ReCoDiD、ORCHESTRA、ZIKAlliance和IDAMS项目所获得的经验为基础。我们认为，观察性队列是必不可少的工具，因为它们提供了关于疾病自然史的急需信息，包括传播途径、易感性因素、严重疾病结果的比例和风险因素，因此为干预研究奠定了基础。CONTAGIO将通过以下方式召集队列调查人员和数据/标本共享专家：a)建立准备和互操作性平台（WP1/2）；b)启用数据共享的一套工具和关键途径（WP2/3）；c)在发生新发感染时制定生物材料共享治理（WP4）。这条道路上的一个关键步骤是调查正在进行的队列如何在发生流行病时（例如从登革热到寨卡再到COVID-19）将其重点从一种传染病“重新调整”到另一种传染病。传染性传染病行动计划所预见的开放科学将建立一个协调机制和框架，使可持续群体在流行病间期防范（重新）出现的传染病方面发挥作用，这对于在更好地应对疾病出现方面取得共同进展，以保护中低收入国家、欧洲和世界其他地区的公民至关重要。

CONTAGIO is a consortium of investigators from Europe, North America, Latin America, Asia, and Africa, that aims to create coordination mechanisms to rapidly react to infectious disease (re-)emergence in low- and middle-income countries (LMICs). The Consortium builds on the experience acquired through the EC-funded projects ReCoDiD, ORCHESTRA, ZIKAlliance, and IDAMS. We believe that observational cohorts are essential instruments as they provide much needed information on the natural history of the disease, including transmission routes, vulnerability factors, the proportion of, and risk factors for, severe disease outcomes and therefore lay the ground for intervention studies. CONTAGIO will convene cohort investigators and data/specimen sharing specialists by a) generating a preparedness and interoperability platform (WP1/2); b) enabling a suite of tools and key pathways for data sharing (WP2/3); and c) developing governance for sharing of biological material in the event of emerging infections (WP4). A key step on this path is the investigation of how ongoing cohorts ‘repurpose’ their focus from one infectious disease to another in the event of epidemics (e.g. from dengue to Zika to COVID-19). The open science foreseen in CONTAGIO will create a coordination mechanism and framework for the role of sustainable cohorts in preparedness for (re-)emerging infectious diseases during interepidemic periods, which will be vital for the joint progress towards a better tackling of disease emergence aimed at the protection of citizens in LMICs, Europe and the rest of the world.