Cohort Network to be Activated Globally in Outbreaks

Conagio是一个由来自欧洲、北美、拉丁美洲、亚洲和非洲的研究人员组成的联盟，旨在建立协调机制，以快速应对低收入和中等收入国家(LMIC)出现的传染病(重新)。该联盟建立在通过欧共体资助的项目ReCoDiD、Orchestra、ZIKAlliance和IDAMS获得的经验基础上。我们认为，观察队列是必不可少的工具，因为它们提供了关于疾病自然历史的迫切需要的信息，包括传播途径、脆弱性因素、严重疾病后果的比例和风险因素，因此为干预研究奠定了基础。康塔吉奥将召集队列调查人员和数据/标本共享专家，方法是a)建立备灾和互操作性平台(WP1/2)；b)启用一套数据共享工具和关键途径(WP2/3)；以及c)制定在新出现感染情况下共享生物材料的治理(WP4)。这条道路上的关键一步是调查持续队列如何在发生流行病(例如从登革热到寨卡病毒再到新冠肺炎)时如何将重点从一种传染病“转移到另一种传染病”。在康塔吉奥会议上预见到的开放式科学将为可持续群体在两次流行期间预防(重新)新发传染病方面的作用建立一个协调机制和框架，这对于共同朝着更好地处理新出现的疾病、保护小岛屿发展中国家、欧洲和世界其他地区的公民的方向取得进展至关重要。

CONTAGIO is a consortium of investigators from Europe, North America, Latin America, Asia, and Africa, that aims to create coordination mechanisms to rapidly react to infectious disease (re-)emergence in low- and middle-income countries (LMICs). The Consortium builds on the experience acquired through the EC-funded projects ReCoDiD, ORCHESTRA, ZIKAlliance, and IDAMS. We believe that observational cohorts are essential instruments as they provide much needed information on the natural history of the disease, including transmission routes, vulnerability factors, the proportion of, and risk factors for, severe disease outcomes and therefore lay the ground for intervention studies. CONTAGIO will convene cohort investigators and data/specimen sharing specialists by a) generating a preparedness and interoperability platform (WP1/2); b) enabling a suite of tools and key pathways for data sharing (WP2/3); and c) developing governance for sharing of biological material in the event of emerging infections (WP4). A key step on this path is the investigation of how ongoing cohorts ‘repurpose’ their focus from one infectious disease to another in the event of epidemics (e.g. from dengue to Zika to COVID-19). The open science foreseen in CONTAGIO will create a coordination mechanism and framework for the role of sustainable cohorts in preparedness for (re-)emerging infectious diseases during interepidemic periods, which will be vital for the joint progress towards a better tackling of disease emergence aimed at the protection of citizens in LMICs, Europe and the rest of the world.