Understanding the mechanisms of class B GPCR-transducer coupling

了解 B 类 GPCR-传感器耦合机制

• 批准号: FT200100218
• 负责人: Dr Peishen Zhao
• 金额: $ 55.06万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT200100218
• 关键词: Understanding; mechanisms; class; GPCR; transducer

Current effort in developing drugs targeting G protein-coupled receptors (GPCRs) often result in low success rate due to the lack of understanding of the complexity and the spatiotemporal control of receptor function. The research program aims to understand the molecular mechanisms of receptor/transducer selectivity. The proposal integrated multi-disciplinary approaches to provide a deeper understanding of how the receptor is activated responding to different ligands. The anticipated outcome including an enhanced capacity for understanding the fundamental biology, a stronger national and international collaborations. This will provide significant benefits including expanded basic knowledge and improvements in drug development efficiency.

目前，由于缺乏对受体功能的复杂性和时空控制的了解，开发靶向G蛋白偶联受体（GPCRs）的药物的努力往往导致成功率低。该研究计划旨在了解受体/换能器选择性的分子机制。该提案整合了多学科方法，以更深入地了解受体如何响应不同的配体被激活。预期成果包括提高理解基础生物学的能力，加强国家和国际合作。这将带来巨大的好处，包括扩大基础知识和提高药物开发效率。