A novel algorithm to compute adherence from electronic adherence monitoring devices

一种计算电子依从性监测设备依从性的新算法

• 批准号: 10516828
• 负责人: Meghan Eileen McGrady
• 金额: $ 22.3万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-06 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10516828
• 关键词: Address; Adherence; Adult; Adverse effects; Algorithm Design; Algorithms; Antineoplastic Agents; Behavior; Biological; Cessation of life; Child; Clinical; Clinical Trials; Code; Complex; Computer software; Data; Development; Diagnosis; Dose; Ensure; Feedback; Focus Groups; Funding; Grant; Hospitals; Hour; Intravenous; Lead; Malignant Neoplasms; Manuals; Measurement; Measures; Methods; Modification; Monitoring Clinical Trials; Names; National Cancer Institute; Nausea; Oncology; Oral; Outcome; Parents; Patient Noncompliance; Patient Self-Report; Patients; Persons; Pharmaceutical Preparations; Pharmacy facility; Procedures; Process; Proxy; Publishing; Records; Regimen; Relapse; Reporter; Reproducibility; Research; Research Personnel; Risk; Running; Science; Scientific Advances and Accomplishments; Sensitivity and Specificity; Series; System; Testing; Time; Treatment Protocols; United States; United States National Institutes of Health; Visit; algorithm development; anti-cancer; anticancer research; cancer therapy; chemotherapy; computerized data processing; cost; design; human error; improved; innovation; medication compliance; microchip; monitoring device; multidisciplinary; novel; novel therapeutics; pill; satisfaction; side effect; social; therapeutic development; tool; uptake; usability

PROJECT SUMMARY/ABSTRACT Medication adherence is a current scientific priority of the National Cancer Institute and a top priority in clinical trials. Electronic adherence monitoring devices (EAMDs) are pill bottles or boxes that contain a computer chip that records the dates and times of each bottle/box opening (or “actuation”). Due to their accuracy and ability to capture day-to-day medication-taking behavior, EAMDs are increasingly cited (i.e., by the FDA) as the preferred measure of daily anticancer medication adherence in research. Unfortunately, researchers currently lack the tools they need to accurately and efficiently convert raw EAMD actuations into adherence data and current methods of completing this task are unstandardized, error-prone, and burdensome. The purpose of this R21 is to develop a novel algorithm to convert EAMD actuations into adherence data. To maximize potential uptake and usability, we will engage a multidisciplinary adherence science focus group to inform the design of the algorithm and associated user interface (Aim 1). We will then evaluate the accuracy of the algorithm in classifying daily adherence data (Aim 2) and obtain quality of use feedback (Aim 3) to inform final refinements prior to large-scale testing.

项目总结/摘要 药物依从性是国家癌症研究所当前的科学优先事项，也是临床的首要任务 审判电子依从性监测设备（EAMD）是含有计算机芯片的药瓶或药盒 记录每个瓶子/盒子打开（或“致动”）的日期和时间。由于其准确性和能力， 捕获日常服药行为，EAMD越来越多地被引用（即，（如FDA） 研究中每日抗癌药物依从性的首选指标。目前，研究人员 缺乏将原始EAMD激励准确有效地转换为依从性数据所需的工具， 当前完成该任务的方法是不标准的、容易出错的和繁琐的。这样做的目的 R21将开发一种新的算法，将EAMD驱动转换为依从性数据。最大限度地发挥潜力 吸收和可用性，我们将聘请一个多学科的坚持科学焦点小组，以告知设计 算法和相关的用户界面（目标1）。然后，我们将评估算法的准确性， 对每日依从性数据进行分类（目标2），并获得使用质量反馈（目标3），以通知最终改进 在大规模测试之前。