Psychomotor and cognitive development problems in a cohort of children after respiratory infection during pregnancy and/or early childhood

摘要 之前的一项研究题为流感的发病率、诊断、治疗效果、疫苗 有效性(INFLUMI-奖：1U01IP000791-01)，这项研究是在2013年 2018年在巴拿马和萨尔瓦多，观察到呼吸道病毒的影响，主要是 在一群妇女(N=2565)及其子女(N=1586)中发现流感。因此，需要 强大的流行病学、临床和实验室监测系统和研究 基础设施。作为儿童评估的一部分，进行了贝利III测试 (n=1088)以确定任何认知、精神运动或语言障碍。现在 该项目建议通过以下方式改善监测、报告和流行病学情报 对8岁以下的儿童进行进一步的随访。的首要目标是 拟议的项目是进一步评估精神运动、认知和精神障碍的患病率。 队列中儿童的行为发育问题。在建议的开始时 项目于2019年11月开始，孩子们将满3.5岁。我们假装跟随他们 被判四年监禁。这将通过建立现有的合作伙伴关系和以前的 研究；支持开发、维护和扩大哨点监视 在巴拿马和萨尔瓦多的网站和通过评估对神经认知发展的影响 妊娠期间频繁和严重的呼吸道感染可能会影响早期 孩子气。过程包括接触儿童和重新引入该系统 第一年。随后的几年将包括流感、流感的培训和能力建设 美洲的防备和其他呼吸道病原体监测。

Abstract A previous study titled Influenza Incidence, Diagnosis, Treatment Efficacy, Vaccine Effectiveness (INFLUMI-Award: 1U01IP000791-01), which was conducted between 2013 and 2018 in Panama and El Salvador, observed the impact of respiratory virus, mainly influenza on a cohort of women (N=2565) and their children (N=1586). Thus, requiring robust epidemiologic, clinical, and laboratory surveillance systems and research infrastructure. As part of the children's evaluation, a Bayley's III test was conducted (N=1088) to determine any cognitive, psychomotor, or language impairment. The present project proposes to improve surveillance, reporting and epidemiological intelligence with further follow-up of the children cohort up to eight (8) years of age. The overarching goal of the proposed project is to further evaluate the prevalence of psychomotor, cognitive, and behavioral development problems among children in the cohort. At start of the proposed Project in November 2019, the children will be 3.5 years of age. We pretend to follow them up for four years. This will be accomplished by building-on existing partnerships and previous research; supporting the development, maintenance, and expansion of sentinel surveillance sites in Panama and El Salvador and by evaluating the effect on neurocognitive development of frequent and severe respiratory infections during pregnancy that might impact early chilhood. Processes include contact of children and re-introduction into the system during the first year. Subsequent years will include training and capacity building of influenza, influenza preparedness, and other respiratory pathogen surveillance in the Americas.