A mobile health tool to improve antibiotic stewardship among village doctors in Bangladesh
移动医疗工具可改善孟加拉国乡村医生的抗生素管理
基本信息
- 批准号:10527016
- 负责人:
- 金额:$ 19.8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-19 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:5 year oldAccountingAcute DiarrheaAgeAntibioticsAntimicrobial ResistanceBangladeshBloodBreast FeedingCar PhoneCaregiversCause of DeathCessation of lifeChildChildhoodClimateClinicalClinical ManagementCollaborationsCross-Over TrialsCustomDataDevelopmentDiagnosisDiagnosticDiarrheaDrug PrescriptionsEtiologyFeasibility StudiesFecesFeverFosteringGoalsHabitsHealthHealth PersonnelHealthcareIndividualKnowledgeLaboratoriesLeadLocationMeasuresMedicalMethodsMobile Health ApplicationModelingModificationMorbidity - disease ratePatient CarePatientsPerformancePhasePhysiciansPopulationPrevalencePrimary Health CareProviderRandomizedRandomized Controlled TrialsRehydrationsRuralSiteSyndromeTestingToxic effectTrainingTrustViralVomitingWorkacceptability and feasibilityantimicrobialbasecare costsclinical applicationclinical decision supportclinical decision-makingcostdiarrheal diseaseevidence basefeasibility trialimplementation strategyimprovedinnovationlow and middle-income countriesmHealthmortalitypathogenpredictive modelingpredictive toolsresearch and developmentrespiratoryrural arearural healthcarerural settingsupport toolstool
项目摘要
Abstract
Diarrheal diseases are the among the leading cause of death in children worldwide, most of which occur in
low- and middle-income countries (LMICs). The cornerstone for management of diarrhea is rehydration, though
antimicrobials are beneficial in some instances. Unfortunately, given that treatment is frequently empiric, based
mostly on clinical suspicion for bacterial causes, antimicrobials are overused in management of diarrheal
illness worldwide. Thus, there is a need for clinical decision support tools to inform clinical management and
promote antimicrobial stewardship. In particular, frontline healthcare providers in rural areas, such as village
doctors in Bangladesh, often have inadequate knowledge for the basis of antimicrobial use, and may benefit
greatly from guidance. We have recently developed a mobile phone based electronic clinical decision-support
tool (eCDST), and shown the impact of etiological prediction on physician antibiotic prescription practices for
pediatric diarrhea in two LMICs. In this proposal, our overarching goal is to customize our eCDST into a
comprehensive mHealth application (Accessible Diarrhea Etiology Prediction Tool, ADEPT) to support rural
health care providers in the management of pediatric diarrhea (R21 phase), and to measure its impact through
the performance of a pilot before-after feasibility study (R33 phase). Our work will contribute to an evidence
base for mHealth-enabled antimicrobial stewardship, with potential to extend beyond diarrheal illness, and into
other syndromes, including respiratory illness and febrile illness.
摘要
腹泻病是全世界儿童死亡的主要原因之一,其中大多数发生在
低收入和中等收入国家(LMIC)。然而,治疗腹泻的基础是补液,
抗菌剂在某些情况下是有益的。不幸的是,由于治疗往往是经验性的,
大多数临床上怀疑是细菌引起的,抗菌药物被过度用于治疗腹泻
世界各地的疾病因此,需要临床决策支持工具来告知临床管理和
促进抗菌管理。特别是,农村地区的一线医疗保健提供者,
孟加拉国的医生通常对抗菌药物使用的基础知识不足,
大的指导。我们最近开发了一种基于移动的电话的电子临床决策支持系统
工具(eCDST),并显示了病原学预测对医生抗生素处方实践的影响,
两个中低收入国家的儿童腹泻。在本提案中,我们的总体目标是将我们的eCDST定制为
综合移动健康应用(腹泻病因预测工具,ADEPT),以支持农村
卫生保健提供者在儿科腹泻的管理(R21阶段),并衡量其影响,通过
可行性研究(R33阶段)试点前后的表现。我们的工作将有助于证明
移动健康支持的抗菌药物管理的基础,有可能扩展到非传染性疾病,
其他综合征,包括呼吸道疾病和发热性疾病。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ashraful Islam Khan其他文献
Safety of a bivalent, killed, whole-cell oral cholera vaccine in pregnant women in Bangladesh: evidence from a randomized placebo-controlled trial
- DOI:
10.1186/s12879-019-4006-3 - 发表时间:
2019-05-15 - 期刊:
- 影响因子:3.000
- 作者:
Ashraful Islam Khan;Mohammad Ali;Julia Lynch;Alamgir Kabir;Jean-Louis Excler;Md. Arifuzzaman Khan;Md. Taufiqul Islam;Afroza Akter;Fahima Chowdhury;Amit Saha;Iqbal Ansary Khan;Sachin N. Desai;Deok Ryun Kim;Nirod Chandra Saha;Ajit P. Singh;John D. Clemens;Firdausi Qadri - 通讯作者:
Firdausi Qadri
Coverage and acceptability of cholera vaccine among high-risk population of urban Dhaka, Bangladesh
- DOI:
10.1016/j.vaccine.2014.08.021 - 发表时间:
2014-09-29 - 期刊:
- 影响因子:
- 作者:
Md. Jasim Uddin;Tasnuva Wahed;Nirod Chandra Saha;Sheikh Shah Tanvir Kaukab;Iqbal Ansary Khan;Ashraful Islam Khan;Amit Saha;Fahima Chowdhury;John David Clemens;Firdausi Qadri - 通讯作者:
Firdausi Qadri
Understanding deaths from diarrhoea in children younger than 5 years
理解 5 岁以下儿童因腹泻导致的死亡
- DOI:
10.1016/s2214-109x(24)00098-6 - 发表时间:
2024-06-01 - 期刊:
- 影响因子:18.000
- 作者:
Ashraful Islam Khan;Mohammad Ashraful Amin - 通讯作者:
Mohammad Ashraful Amin
Comparison of O-specific polysaccharide responses in patients following infection with emVibrio cholerae/em O139 versus vaccination with a bivalent (O1/O139) oral killed cholera vaccine in Bangladesh
孟加拉国感染 em 霍乱弧菌/O139 后患者与接种二价(O1/O139)口服灭活霍乱疫苗后患者 O 特异性多糖反应的比较
- DOI:
10.1128/msphere.00255-23 - 发表时间:
2023-09-28 - 期刊:
- 影响因子:3.100
- 作者:
M. Hasanul Kaisar;Meagan Kelly;Mohammad Kamruzzaman;Taufiqur R. Bhuiyan;Fahima Chowdhury;Ashraful Islam Khan;Regina C. LaRocque;Stephen B. Calderwood;Jason B. Harris;Richelle C. Charles;Alžbeta Čížová;Jana Mečárová;Jana Korcová;Slavomír Bystrický;Pavol Kováč;Peng Xu;Firdausi Qadri;Edward T. Ryan;David W. Pascual - 通讯作者:
David W. Pascual
Antibiotic resistance and serotype distribution of emShigella/em strains in Bangladesh over the period of 2014–2022: evidence from a nationwide hospital-based surveillance for cholera and other diarrheal diseases
2014-2022 年期间孟加拉国志贺氏菌属菌株的抗生素耐药性和血清型分布:全国医院霍乱及其他腹泻病监测的证据
- DOI:
10.1128/spectrum.00739-24 - 发表时间:
2024-10-30 - 期刊:
- 影响因子:3.800
- 作者:
Mokibul Hassan Afrad;Md. Taufiqul Islam;Yasmin Ara Begum;Md. Saifullah;Faisal Ahmmed;Zahid Hasan Khan;Zakir Hossain Habib;Ahmed Nawsher Alam;Tahmina Shirin;Taufiqur Rahman Bhuiyan;Edward T. Ryan;Ashraful Islam Khan;Firdausi Qadri - 通讯作者:
Firdausi Qadri
Ashraful Islam Khan的其他文献
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{{ truncateString('Ashraful Islam Khan', 18)}}的其他基金
A mobile health tool to improve antibiotic stewardship among village doctors in Bangladesh
移动医疗工具可改善孟加拉国乡村医生的抗生素管理
- 批准号:
10707328 - 财政年份:2022
- 资助金额:
$ 19.8万 - 项目类别:
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