Do Changes in Diet Quality in a Weight Loss Trial Affect Cardiometabolic Risk?

减肥试验中饮食质量的改变会影响心脏代谢风险吗？郑洁 项目总结/摘要 虽然饮食对减肥、预防慢性病和整体健康的重要性 研究人员早就清楚，减肥干预研究有利于减少热量和脂肪 该报告没有严格评估和报告干预措施对饮食质量的影响。 拟议的研究项目将根据24小时饮食回忆数据评估饮食质量变化 作为SMARTER随机对照试验（R 01 HL 131583）的一部分收集。SMARTER试验评估了 提供实时定制反馈信息对自我监测饮食、身体状况、 活动和体重与没有反馈的自我监测相比。健康饮食指数（Healthy Eating Index） 目前的美国人饮食指南，可以从24小时的饮食回忆计算， 在基线、6个月和12个月时采集。基于实验室的体重、血压和腰围测量 在基线、6个月和12个月时收集周长。利用大型单中心试验的数据 （N=530）有可能通过量化体重减轻多少来告知公共卫生界 有针对性的反馈干预改善了饮食质量。这项工作对于制定干预措施至关重要， 可以实现与增加水果，蔬菜和蔬菜的贡献有关的健康人2020目标， 全谷物的总饮食，以及减少消费的添加糖和饱和脂肪。 目标1将评估减肥干预如何在饮食质量方面产生变化， 基线至6个月和6至12个月。在目标2中，饮食质量的变化与 心脏代谢风险因素（即体重状态、血压和腰围）的变化， 将对所有参与者的基线至6个月和6至12个月进行量化。次级目标是 探索个人所采用的饮食质量变化的组成部分，以及哪些组成部分导致更大的 降低风险因素。探索性目标3将检查计算的饮食质量 分数和参与者感知的饮食质量以及饮食变化之间的关系 质量评分以及参与者如何感知他们的饮食质量随时间而变化。 奖学金培训将使我能够增加我的营养流行病学知识和知识， 与肥胖和慢性疾病发展相关的因素。我也将学习如何支持行为 改变解决这些因素，并提高我的批判性思维和分析的复杂性和严谨性 skills.这种培训将为在会议上介绍研究成果提供宝贵的机会， 提交给同行评审的期刊，并让我获得与多学科团队合作的经验。 这项研究将作为一个垫脚石，准备期间和博士后工作后， 我希望继续研究行为生活方式干预对预防慢性病的作用。 1

Do Changes in Diet Quality in a Weight Loss Trial Affect Cardiometabolic Risk? Jessica Cheng Project Summary/Abstract Although the importance of diet for weight loss, the prevention of chronic disease, and overall health has long been clear to researchers, weight loss intervention research favors calorie and fat reduction approaches but does not rigorously assess and report the impact of interventions on diet quality. The proposed research project will assess diet quality change based on 24-hour dietary recall data collected as part of the SMARTER randomized control trial (R01 HL131583). The SMARTER trial evaluates the effect on weight loss of providing real-time tailored feedback messages on self-monitored diet, physical activity, and weight compared to self-monitoring with no feedback. The Healthy Eating Index, which aligns with the current Dietary Guidelines for Americans, can be calculated from 24-hour dietary recalls which are collected at baseline, 6-, and 12-months. Lab-based measurements of weight, blood pressure, and waist circumference are collected at baseline, 6, and 12 months. Leveraging data from a large single-site trial (N=530) has the potential to inform the public health community by quantifying how much a weight loss intervention with tailored feedback improves diet quality. This work is vital to developing interventions which can achieve Healthy People 2020 objectives related to increasing the contributions of fruits, vegetables, and whole grains to the total diet as well as decreasing the consumption of added sugars and saturated fats. Aim 1 will assess how a weight loss intervention performs in producing changes in diet quality from baseline to 6-months and 6- to 12-months. In Aim 2, the relationship between change in diet quality and change in cardiometabolic risk factors (i.e. weight status, blood pressure, and waist circumference) from baseline to 6 months and from 6- to 12-months will be quantified among all participants. A sub-aim is to explore the components of diet quality change adopted by individuals and which components result in greater decreases in risk factors. Exploratory Aim 3 will examine the relationship between calculated diet quality scores and participants’ perceived diet quality as well as the relationship between calculated changes in diet quality score and how participants perceived their diet quality changed over time. Fellowship training will enable me to increase my nutritional epidemiology knowledge and knowledge of factors related to the development of obesity and chronic disease. I will also learn how to support behavior change addressing those factors and increase the sophistication and rigor of my critical thinking and analytic skills. This training will provide valuable opportunities for the presentation of research at conferences and submission to peer-reviewed journals and allow me to gain experience working with a multidisciplinary team. This research will serve as a steppingstone to preparing grants during and after post-doctoral work during which I hope to continue investigating behavioral lifestyle interventions for the prevention of chronic disease. 1