Do Changes in Diet Quality in a Weight Loss Trial Affect Cardiometabolic Risk?

减肥试验中饮食质量的改变是否会影响心脏代谢风险？郑洁 项目摘要/摘要 尽管饮食对减肥、预防慢性病和整体健康的重要性 研究人员早就清楚，减肥干预研究有利于减少卡路里和脂肪 对饮食质量的干预方法，但没有严格评估和报告干预对饮食质量的影响。 拟议的研究项目将基于24小时饮食回忆数据来评估饮食质量的变化 作为更智能的随机对照试验(R01 HL131583)的一部分收集。更聪明的试验评估 自我监测饮食、体检提供实时量身定制反馈信息对减肥的影响 活动量和体重与没有反馈的自我监测相比。健康饮食指数，与 目前的美国饮食指南可以从24小时的饮食召回中计算出来，这些召回是 在基线、6个月和12个月时收集。基于实验室的体重、血压和腰围测量 在基线、6个月和12个月时收集周长。利用来自大型单站点试验的数据 (n=530)有可能通过量化体重减轻多少来告知公共卫生界 通过量身定制的反馈进行干预，可以改善饮食质量。这项工作对于制定干预措施至关重要， 能够实现2020年与增加水果、蔬菜和 将全谷物添加到总饮食中，并减少添加糖和饱和脂肪的摄入量。 目标1将评估减肥干预如何在改变饮食质量方面发挥作用 基线为6个月和6至12个月。在目标2中，饮食质量的变化与 心脏代谢危险因素(即体重状况、血压和腰围)的变化 将在所有参与者中量化6个月的基线和6至12个月的基线。一个次要目标是 探索个人采用的饮食质量变化的组成部分，以及哪些组成部分会导致更大的 风险因素减少。探索性目标3将检查计算的饮食质量之间的关系 得分与参与者感知的饮食质量以及计算的饮食变化之间的关系 质量分数以及参与者如何感知他们的饮食质量随着时间的推移而变化。 团契培训将使我能够增加我的营养流行病学知识和 与肥胖和慢性病的发展有关的因素。我还将学习如何支持行为 改变应对这些因素，提高我批判性思维和分析的复杂性和严谨性 技能。这种培训将提供宝贵的机会，以便在会议和 提交给同行评议的期刊，让我获得与多学科团队合作的经验。 这项研究将作为在博士后工作期间和之后准备资助的垫脚石 我希望继续研究预防慢性病的行为生活方式干预。 1

Do Changes in Diet Quality in a Weight Loss Trial Affect Cardiometabolic Risk? Jessica Cheng Project Summary/Abstract Although the importance of diet for weight loss, the prevention of chronic disease, and overall health has long been clear to researchers, weight loss intervention research favors calorie and fat reduction approaches but does not rigorously assess and report the impact of interventions on diet quality. The proposed research project will assess diet quality change based on 24-hour dietary recall data collected as part of the SMARTER randomized control trial (R01 HL131583). The SMARTER trial evaluates the effect on weight loss of providing real-time tailored feedback messages on self-monitored diet, physical activity, and weight compared to self-monitoring with no feedback. The Healthy Eating Index, which aligns with the current Dietary Guidelines for Americans, can be calculated from 24-hour dietary recalls which are collected at baseline, 6-, and 12-months. Lab-based measurements of weight, blood pressure, and waist circumference are collected at baseline, 6, and 12 months. Leveraging data from a large single-site trial (N=530) has the potential to inform the public health community by quantifying how much a weight loss intervention with tailored feedback improves diet quality. This work is vital to developing interventions which can achieve Healthy People 2020 objectives related to increasing the contributions of fruits, vegetables, and whole grains to the total diet as well as decreasing the consumption of added sugars and saturated fats. Aim 1 will assess how a weight loss intervention performs in producing changes in diet quality from baseline to 6-months and 6- to 12-months. In Aim 2, the relationship between change in diet quality and change in cardiometabolic risk factors (i.e. weight status, blood pressure, and waist circumference) from baseline to 6 months and from 6- to 12-months will be quantified among all participants. A sub-aim is to explore the components of diet quality change adopted by individuals and which components result in greater decreases in risk factors. Exploratory Aim 3 will examine the relationship between calculated diet quality scores and participants’ perceived diet quality as well as the relationship between calculated changes in diet quality score and how participants perceived their diet quality changed over time. Fellowship training will enable me to increase my nutritional epidemiology knowledge and knowledge of factors related to the development of obesity and chronic disease. I will also learn how to support behavior change addressing those factors and increase the sophistication and rigor of my critical thinking and analytic skills. This training will provide valuable opportunities for the presentation of research at conferences and submission to peer-reviewed journals and allow me to gain experience working with a multidisciplinary team. This research will serve as a steppingstone to preparing grants during and after post-doctoral work during which I hope to continue investigating behavioral lifestyle interventions for the prevention of chronic disease. 1