Toxoplasma F-Box Protein Regulation of the Apicoplast
弓形虫 F-Box 蛋白对顶质体的调节
基本信息
- 批准号:10539694
- 负责人:
- 金额:$ 23.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-05-23 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:AffectArchitectureCell CycleCell NucleusCell physiologyCellsCo-ImmunoprecipitationsComplexCullin ProteinsDataDaughterDefectDrug TargetingEnzymesEssential GenesEuchromatinEukaryotaF Box DomainF-Box ProteinsFamilyFutureGene ExpressionGenomeGoalsGrowthHistone H3MediatingMembraneMetabolicMetabolismMicroscopyMitoticOrganellesParasitesPathway interactionsPlasmodiumPlastidsPost-Translational Protein ProcessingProtein Complex SubunitProtein SubunitsProteinsProteomeRegulationResolutionSignal TransductionSpecificityStructureTestingToxoplasmaToxoplasma gondiiUbiquitinationWorkcandidate identificationfitnessgene productmulticatalytic endopeptidase complexnovelpathogenprotein degradationrecruittraffickingubiquitin ligaseubiquitin-protein ligase
项目摘要
The SKP1/Cullin/F-box (SCF) class of E3 Ubiquitin Ligases is an evolutionarily
conserved family of enzymes that regulate key cellular processes including the cell
cycle, membrane trafficking, and signaling. The SCF-E3 is composed of four core
components - Rbx1, Cullin1, SKP1, and a F-box protein. F-box proteins are the
subunits that recruit substrate proteins to be poly-ubiquitinated by the SCF-E3, and they
can also be directly poly-ubiquitinated. In previous work, we discovered that the
Toxoplasma genome contains 18 predicted F-box proteins and one of these, TgFBLX2,
is predicted to be the most important for fitness. We now find that TgFBLX2 is indeed
important for parasite growth and in its absence inheritance of the apicoplast, a relic
plastid that serves as an important metabolic hub, is reduced. We further find that
TgFBLX2 localizes to a unique perinucleolar compartment. The goal of this project is to
define how TgFBLX2 mediates parasite growth. In the first aim, we will determine how
TgFBLX2 regulates apicoplast inheritance. In the second aim, we will characterize the
perinucleolar compartment in which TgFBLX2 resides. These studies are significant
because they will reveal novel interactions between the nucleus and apicoplast. In
addition, these findings may be relevant to related pathogens since TgFBLX2 is
conserved in Plasmodium and other apicomplexans.
SKP1/Cullin/F-box (SCF)类E3泛素连接酶是一个进化上的
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Ira J Blader其他文献
Ira J Blader的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Ira J Blader', 18)}}的其他基金
Protist Oxygen Sensing in Human Disease Protist Oxygen Sensing in Human Disease
人类疾病中的原生生物氧传感 人类疾病中的原生生物氧传感
- 批准号:
10467358 - 财政年份:2022
- 资助金额:
$ 23.99万 - 项目类别:
Toxoplasma F-Box Protein Regulation of the Apicoplast
弓形虫 F-Box 蛋白对顶质体的调节
- 批准号:
10626164 - 财政年份:2022
- 资助金额:
$ 23.99万 - 项目类别:
Protist Oxygen Sensing in Human Disease Protist Oxygen Sensing in Human Disease
人类疾病中的原生生物氧传感 人类疾病中的原生生物氧传感
- 批准号:
10651752 - 财政年份:2022
- 资助金额:
$ 23.99万 - 项目类别:
The Organization and Function of the Toxoplasma Daughter Cell Scaffold
弓形虫子细胞支架的组织和功能
- 批准号:
10533770 - 财政年份:2020
- 资助金额:
$ 23.99万 - 项目类别:
Identification of F-Box Proteins in Toxoplasma
弓形虫中 F-Box 蛋白的鉴定
- 批准号:
9974899 - 财政年份:2020
- 资助金额:
$ 23.99万 - 项目类别:
The Organization and Function of the Toxoplasma Daughter Cell Scaffold
弓形虫子细胞支架的组织和功能
- 批准号:
9917284 - 财政年份:2020
- 资助金额:
$ 23.99万 - 项目类别:
The Organization and Function of the Toxoplasma Daughter Cell Scaffold
弓形虫子细胞支架的组织和功能
- 批准号:
10083185 - 财政年份:2020
- 资助金额:
$ 23.99万 - 项目类别:
The Organization and Function of the Toxoplasma Daughter Cell Scaffold
弓形虫子细胞支架的组织和功能
- 批准号:
10320439 - 财政年份:2020
- 资助金额:
$ 23.99万 - 项目类别:
Toxoplasma gondii Regulation of Host GABAergic Signaling
弓形虫对宿主 GABA 信号传导的调节
- 批准号:
9212770 - 财政年份:2016
- 资助金额:
$ 23.99万 - 项目类别:
Oxygen Sensing by the AIDS Opportunist Pathogen, Toxoplasma gondii
艾滋病机会病原体弓形虫的氧感应
- 批准号:
8923613 - 财政年份:2015
- 资助金额:
$ 23.99万 - 项目类别:
相似海外基金
CAREER: Efficient Algorithms for Modern Computer Architecture
职业:现代计算机架构的高效算法
- 批准号:
2339310 - 财政年份:2024
- 资助金额:
$ 23.99万 - 项目类别:
Continuing Grant
Hardware-aware Network Architecture Search under ML Training workloads
ML 训练工作负载下的硬件感知网络架构搜索
- 批准号:
2904511 - 财政年份:2024
- 资助金额:
$ 23.99万 - 项目类别:
Studentship
CAREER: Creating Tough, Sustainable Materials Using Fracture Size-Effects and Architecture
职业:利用断裂尺寸效应和架构创造坚韧、可持续的材料
- 批准号:
2339197 - 财政年份:2024
- 资助金额:
$ 23.99万 - 项目类别:
Standard Grant
Travel: Student Travel Support for the 51st International Symposium on Computer Architecture (ISCA)
旅行:第 51 届计算机体系结构国际研讨会 (ISCA) 的学生旅行支持
- 批准号:
2409279 - 财政年份:2024
- 资助金额:
$ 23.99万 - 项目类别:
Standard Grant
Understanding Architecture Hierarchy of Polymer Networks to Control Mechanical Responses
了解聚合物网络的架构层次结构以控制机械响应
- 批准号:
2419386 - 财政年份:2024
- 资助金额:
$ 23.99万 - 项目类别:
Standard Grant
I-Corps: Highly Scalable Differential Power Processing Architecture
I-Corps:高度可扩展的差分电源处理架构
- 批准号:
2348571 - 财政年份:2024
- 资助金额:
$ 23.99万 - 项目类别:
Standard Grant
Collaborative Research: Merging Human Creativity with Computational Intelligence for the Design of Next Generation Responsive Architecture
协作研究:将人类创造力与计算智能相结合,设计下一代响应式架构
- 批准号:
2329759 - 财政年份:2024
- 资助金额:
$ 23.99万 - 项目类别:
Standard Grant
The architecture and evolution of host control in a microbial symbiosis
微生物共生中宿主控制的结构和进化
- 批准号:
BB/X014657/1 - 财政年份:2024
- 资助金额:
$ 23.99万 - 项目类别:
Research Grant
RACCTURK: Rock-cut Architecture and Christian Communities in Turkey, from Antiquity to 1923
RACCTURK:土耳其的岩石建筑和基督教社区,从古代到 1923 年
- 批准号:
EP/Y028120/1 - 财政年份:2024
- 资助金额:
$ 23.99万 - 项目类别:
Fellowship
NSF Convergence Accelerator Track M: Bio-Inspired Surface Design for High Performance Mechanical Tracking Solar Collection Skins in Architecture
NSF Convergence Accelerator Track M:建筑中高性能机械跟踪太阳能收集表皮的仿生表面设计
- 批准号:
2344424 - 财政年份:2024
- 资助金额:
$ 23.99万 - 项目类别:
Standard Grant