Developing and testing a telehealth intervention to increase HIV pre-exposure prophylaxis uptake and adherence among sexual minority men in Nigeria

开发和测试远程医疗干预措施，以提高尼日利亚性少数男性对艾滋病毒暴露前预防的接受度和依从性

• 批准号: 10542292
• 负责人: Adedotun Ogunbajo
• 金额: $ 19.85万
• 依托单位: RAND CORPORATION
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10542292
• 关键词: AIDS prevention; Adherence; Africa South of the Sahara; Awareness; Behavior Therapy; Biological Assay; Blood; Caring; Cellular Phone; Clinic; Consolidated Framework for Implementation Research; Data; Development; Epidemic; Epidemiology; Face; Funding; Future; General Population; Goals; Grant; HIV; HIV Infections; HIV Seronegativity; Health Personnel; Health Services; Homophobia; Homosexuality; Hour; Human immunodeficiency virus test; Incidence; Intervention; Interview; Knowledge; Mentorship; Modeling; Nigeria; Nigerian; Oral; Outcome; Output; Ownership; Persons; Phase; Population; Positioning Attribute; Process; Qualitative Methods; Randomized; Randomized Controlled Trials; Research; Research Personnel; Research Training; Risk; Services; Spottings; Structure; Telemedicine; Testing; Training; Treatment Efficacy; Victimization; Vulnerable Populations; acceptability and feasibility; care outcomes; community based participatory research; cost; design; digital health; eligible participant; feasibility testing; follow-up; high risk; implementation barriers; implementation framework; implementation science; improved; innovation; iterative design; peer; pre-exposure prophylaxis; prototype; randomized trial; self testing; sexual minority men; social cognitive theory; social stigma; telehealth; therapy development; treatment services; uptake

PROJECT SUMMARY Background. In Nigeria, sexual minority men (SMM) have disproportionately higher levels of HIV compared to the general population. With high adherence, daily oral pre-exposure prophylaxis (PrEP) reduces risk for HIV acquisition among SMM. Increasing PrEP uptake and adherence could significantly reduce HIV incidence, but to date no PrEP intervention have focused on SMM in Nigeria. The scientific premise of this K01 application is that a telehealth delivery model for PrEP could circumvent barriers to PrEP access for SMM in Nigeria. There is a strong proof of concept for the proposed approach given that telehealth interventions to enhance PrEP access have been shown to be acceptable and have increased PrEP uptake and adherence, among SMM in the U.S. While telehealth interventions in Nigeria have increased utilization of other health services, no study has investigated the feasibility, acceptability, and efficacy of delivering PrEP health services to SMM in Nigeria through a telehealth approach. Overview of project. My long-term goal is to become an independent researcher with expertise in developing and testing telehealth interventions to improve HIV prevention and care outcomes among SMM in sub-Saharan Africa. In Year 1, I will conduct qualitative interviews with HIV-negative SMM (n=20), peer educators (n=20), and healthcare providers (n=20) in Lagos Nigeria to identify the content, format, and foreseeable challenges to implementing a telemedicine intervention to increase PrEP awareness, uptake, and adherence among SMM. In Year 2, I will conduct qualitative interviews with SMM (n=30) to iteratively design a telemedicine intervention to increase PrEP uptake and adherence among SMM in Lagos, Nigeria. In Years 3-5, I will conduct a pilot randomized controlled trial (RCT) to test the feasibility, acceptability, and preliminary efficacy of the telemedicine intervention to optimize PrEP adherence over 6 months with 90 PrEP-naïve, HIV-negative high risk SMM in Lagos, Nigeria. My successful completion of the proposed research and training aims will position me to submit a R01 in the final year of this grant to conduct a multisite, RCT to test the intervention’s efficacy.

项目总结