Micronutriomics for Population-Level Women, Infant, and Child-focused Public Health Interventions

针对人口层面的妇女、婴儿和儿童的公共卫生干预措施的微量营养组学

• 批准号: 10541075
• 负责人: Lindsay H Allen
• 金额: $ 1万
• 依托单位: AMERICAN SOCIETY FOR NUTRITION, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-19 至 2023-09-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10541075
• 关键词: Adolescent; American; Anthropometry; Area; Biological Markers; Biology; Birth; Child; Child Development; Chronic; Clinical; Collaborations; Communities; Complex; Data; Dietary Intervention; Dietary intake; Future; Genome; Genomics; Growth; Growth and Development function; Health; High-Risk Pregnancy; Human Development; Infant; Inflammation; Intake; Intervention; Joints; Knowledge; Lactation; Lead; Learning; Maternal and Child Health; Measures; Metabolic; Metabolism; Methodology; Methods; Micronutrients; Molecular; National Institute of Child Health and Human Development; Nutrient; Nutritional; Nutritional Study; Nutritional status; Outcome; Population; Populations at Risk; Pregnancy; Pregnancy Outcome; Pregnant Women; Proteome; Proteomics; Public Health; Research; Research Personnel; Resources; Review Literature; Risk; Risk Factors; Role; Sampling; Scientist; Societies; Source; Supplementation; Symptoms; System; Technology; Underrepresented Populations; Woman; base; disorder prevention; fetal; fortification; global health; improved; improved outcome; interest; intervention program; metabolome; micronutrient deficiency; multidisciplinary; nutrition; pregnant; public health intervention; symposium; tool; wasting

1 Project Summary/Abstract 2 3 Omic methodologies can improve our understanding of the metabolic, proteomic and genomic 4 consequences of micronutrient deficiencies and interventions in undernourished populations including 5 pregnant women, children and adolescents. Specifically, this conference will examine the use of new 6 omic technologies and methods to assess the effects of nutritional status on health; improve 7 assessment and interventions; and broaden knowledge on the impact of nutrition on pregnancy and 8 fetal, child and adolescent growth and development. The use of omics to detect the impact of 9 micronutrient interventions will result in tremendous public health learnings related to pregnancy 10 outcome and child development. 11 12 Low intakes of many micronutrients are common in many underrepresented populations, resulting in 13 chronic, marginal deficiencies which may not produce clinical symptoms, but likely cause underlying 14 metabolic changes that are difficult to identify. Similarly, micronutrient interventions, either with single 15 or multiple micronutrients, are likely to cause myriad metabolic changes of consequence to health that 16 are not yet identified. Omics is a powerful tool that will elucidate the effects of micronutrient 17 deficiencies and interventions at the population level. Little is known about subclinical and/or marginal 18 micronutrient deficiencies on metabolism and health of underrepresented populations, or the effects of 19 micronutrient interventions on the metabolome, the genome or the proteome. Given the enormous 20 ongoing efforts in micronutrient supplementation and fortification world-wide, these are critical 21 knowledge gaps. Convening experts in omics and experts in population-level micronutrient nutrition 22 research and intervention programs and the planned collaborative discussions will highlight future 23 joint research opportunities, as well as available samples and analyses, for both basic and applied 24 investigators in the area of public health nutrition specific to maternal and child health. The conference 25 will allow researchers to prioritize existing samples and analyses of maternal and birth to 24-months 26 populations that are available and identify investigators who will lead future omics analyses. Through 27 omics, we can understand and improve outcomes of global public health importance related to high- 28 risk pregnancy, child and adolescent growth, wasting, stunting, inflammation, maternal and child 29 survival, and disease prevention.

1项目概要/摘要 2 3 Omic方法可以提高我们对代谢、蛋白质组学和基因组学的理解。 4营养不良人口中微量营养素缺乏的后果和干预措施， 5名孕妇、儿童和青少年。具体来说，这次会议将审查新的 6组学技术和方法来评估营养状况对健康的影响;改善 7评估和干预措施;并扩大关于营养对怀孕的影响的知识， 8胎儿、儿童和青少年的生长发育。使用组学来检测 9微量营养素干预措施将导致大量与怀孕有关的公共卫生知识 10结果和儿童发展。 11 12在许多代表性不足的人口中，许多微量营养素摄入量低是常见的， 13种可能不会产生临床症状，但可能导致潜在疾病的慢性、边缘性缺陷 14代谢的变化是很难确定的。同样，微量营养素干预措施，无论是单一的 15或多种微量营养素，可能会导致无数的代谢变化的后果，健康， 16人尚未确定。组学是阐明微量营养素作用的有力工具 17在人口一级的缺陷和干预措施。关于亚临床和/或边缘性 18微量营养素缺乏对代表性不足人口的新陈代谢和健康的影响，或 19种微量营养素对代谢组、基因组或蛋白质组的干预。鉴于巨大的 20正在进行的努力，在微量营养素补充和强化世界各地，这些都是至关重要的 21个知识缺口召集组学专家和人口微量营养素营养专家 22项研究和干预计划以及计划中的合作讨论将突出未来 基础和应用领域的23个联合研究机会，以及现有样本和分析 24名调查员在公共卫生营养领域专门从事妇幼保健工作。会议 25将使研究人员能够优先考虑现有的样本和分析产妇和出生到24个月 26个可用的人群，并确定将领导未来组学分析的研究人员。通过 27组学，我们可以理解和改善与高相关的全球公共卫生重要性的结果， 28怀孕、儿童和青少年发育、消瘦、发育不良、炎症、孕产妇和儿童 29、预防疾病。