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Organizational and Cultural Dynamics in Genomics Companies: Industry Engagement in Navigating Social and Ethical Issues

基因组公司的组织和文化动态：行业参与解决社会和道德问题

基本信息

批准号：
10542816
负责人：
Alexis Walker
金额：
$ 24.9万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-01-12 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10542816
关键词：
Address Agreement American Area Attention Award Back Bioethics Bioethics Consultants Biotechnology Boston Businesses California Case Study Comparative Study Complement Corporate Ethics DNA Decision Making Delphi Study Development Development Plans Diagnostic Disparity Empirical Research Employee Entrepreneurship Equity Ethical Issues Ethics Face Genetic Genomic approach Genomics Goals Government Health Health Technology India Individual Industrialization Industry Inequality Intervention Interview Investigation Justice Licensing Light Link Machine Learning Marketing Methods Modeling National Human Genome Research Institute Pathway interactions Patients Perception Persons Phase Play Policies Price Privacy Private Enterprises Private Sector Privatization Process Public Health Questionnaires Research Research Priority Research Project Grants Role Scholarship Schools Science Shapes Silicon Site Social Justice Social Obligations Social Responsibility South Africa South African Strategic Planning Structure Technology Therapeutic Training Training Activity Training Programs Universities Work career development comparative curative treatments design drug development ethical, legal, and social implication experience gene therapy genome editing improved individual response innovation insight member nebula next generation sequencing novel diagnostics novel therapeutics operation population health programs research and development social theories training project

项目摘要

This K99/R00 Award is designed to generate scholarship and interventions to guide genomics companies towards more just practices. It does so through a five-year training and research project, which investigates perspectives from members of the genomics industry, and leverages them to inform normative analyses and identify feasible paths towards concrete change. The project addresses issues of price, access and industrial control, with a focus on the ethics of profit and social responsibility. Through the proposed training program, the project prepares the candidate as an independent scholar whose research program links empirical and normative research with practical interventions to positively influence ethics and justice in private sector genomics. The first phase of research (conducted during the K phase, alongside training activities) is a comparative study examining social and cultural factors involved in perceptions of ethical issues among members of industry. The comparative study focuses on three biotech hubs in the US (the Bay Area, San Diego, and Boston), as well as an additional site in South Africa (Cape Town). The South African site helps place investigation of the US industry in light of a shifting global industry, and especially South Africa’s policy focus on genomics for population health (as well as its role in the H3Africa initiative). The study also considers industry subsector and individual company culture, in examining influences on industry approaches to social and ethical issues. During its R phase, the project then involves a systematic normative analysis of profit and social obligation in the genomics industry, based on key theories from bioethics and business ethics. The project will then feed this scholarly analysis back to industry stakeholders; using a Delphi study, it allows members of industry to use results of the normative analysis in strategizing interventions with the greatest likelihood of influencing the genomics industry in ethically desirable ways. This project addresses the NHGRI ELSI research priorities of genomic equity and social justice, as well as genomics and public health. Its career development plan focuses on training in normative analysis and Delphi methods, as well as content training in genomics and entrepreneurship. The training will be conducted at Johns Hopkins University, where the school’s preeminent bioethics center houses world experts in qualitative and quantitative empirical bioethics, alongside the University’s leading research and training in the biomedical sciences and their application in industry. The integrated research and training plan will prepare the candidate as an independent ELSI scholar with a rigorous research program focused on empirical and normative analysis of the business of biomedicine and genomics, and engagement with industry stakeholders.

K99/R00奖旨在产生奖学金和干预措施，以指导基因组学公司