Mentoring Patient-Oriented Research on Advances to Optimize Engagement in HIV Care

项目摘要 Christopoulos 博士是一名传染病医生，也是该科的医学副教授 加州大学旧金山分校的艾滋病毒、感染性疾病和全球医学。她过去十年的研究重点是改善 通过识别那些有参与不良风险的人，参与对服务不足的城市人口的艾滋病毒护理， 了解参与的障碍和促进因素，并制定支持参与的干预措施。 她指导了许多早期职业研究人员，包括博士前学生、博士后研究员、 和初级教师，但现在寻求 K24 奖项的受保护时间，以增加她的深度和范围 指导，进行专门的指导技能培训，并发展以患者为导向的研究计划。 COVID-19 大流行进一步凸显了对创新影响进行严格评估的必要性 艾滋病毒护理服务中，以确保其使用不会扩大艾滋病毒健康差距。在这个应用程序中，博士。 Christopoulos 提出了一项全面的指导、研究和职业发展计划，以促进 在新冠疫情后的环境中公平地提供艾滋病毒护理和治疗。充分利用基础设施 综合临床系统 (CNICS) 的 CFAR 网络以及她作为 UCSF 站点 PI 的角色，该研究提出于 该应用程序旨在调查艾滋病毒护理和治疗方面进步的影响，即远程医疗、长期护理 注射抗逆转录病毒治疗，保留和抑制病毒。除了资源之外 CNICS 包括一个指导核心，Christopoulos 博士将利用实施科学 R01 长期 加州大学旧金山分校 (UCSF) 的注射抗逆转录病毒疗法、培训和职业资源，以及强大的网络 多学科合作者为学员提供培训机会、初步数据和平台 在此基础上开展新的研究。通过经验丰富的资深导师团队的指导，正式 教学法和受指导者的反馈，她将增强和规范她的指导能力和方法 跨差异指导和支持代表性不足的少数群体 (URM) 的额外培训 研究人员在她的指导和研究中建立了公平的关注点。 K24 有助于 实现她的长期职业目标，成为参与艾滋病毒主题的国际领导者 通过培训下一代研究人员重点关注并最大限度地发挥她的科学追求的影响 优化艾滋病毒护理参与度。

Project Abstract Dr. Christopoulos is an infectious disease physician and Associate Professor of Medicine in the Division of HIV, ID, and Global Medicine at UCSF. Her research over the past ten years has focused on improving engagement in HIV care for underserved urban populations by identifying those at risk for poor engagement, understanding barriers to and facilitators of engagement, and developing interventions to support engagement. She has mentored numerous early career investigators, including pre-doctoral students, post-doctoral fellows, and junior faculty but now seeks the protected time of the K24 award to increase the depth and scope of her mentorship, undertake dedicated mentorship skills training, and grow her program of patient oriented research. The COVID-19 pandemic has highlighted further the need for rigorous evaluation of the impact of innovations in HIV care delivery to ensure their use does not widen HIV health disparities. In this application, Dr. Christopoulos proposes a comprehensive mentoring, research, and career development plan to promote the equitable delivery of HIV care and treatment in a post-COVID landscape. Leveraging the infrastructure of the CFAR Network of Integrated Clinical Systems (CNICS) and her role as UCSF site PI, the research proposed in this application seeks to investigate the impact of advances in HIV care and treatment, i.e., telehealth, long- acting injectable antiretroviral therapy, on retention and viral suppression. In addition to the resources of CNICS, which include a mentoring core, Dr. Christopoulos will utilize an implementation science R01 on long- acting injectable antiretroviral therapy, training and career resources at UCSF, and a robust network of multidisciplinary collaborators to provide mentees with training opportunities, preliminary data, and platforms on which to build new research. Through the guidance of an experienced senior mentoring team, formal didactics, and mentee feedback, she will augment and formalize her mentoring abilities and approach with additional training in mentoring across differences and supporting under-represented minority (URM) investigators, building an equity focus in her mentoring as well as her research. The K24 is instrumental to achieving her long-term career goals of becoming an international leader on the topic of engagement in HIV care and maximizing the impact of her scientific pursuits by training the next generation of researchers focused on optimizing HIV care engagement.