Mentoring Patient-Oriented Research on Advances to Optimize Engagement in HIV Care

项目摘要 克里斯托普洛斯博士是传染病内科医生和医学副教授 加州大学旧金山分校的艾滋病毒、身份识别和全球医学。在过去的十年里，她的研究重点是改进 参与对服务不足的城市人口的艾滋病毒护理，确定那些参与度较低的风险人群， 了解参与的障碍和促进者，并制定支持参与的干预措施。 她曾指导过许多早期职业研究人员，包括博士后学生、博士后研究员、 和初级教员，但现在寻求K24奖项的保护时间，以增加她的深度和广度 指导，进行专门的指导技能培训，并发展她的以患者为导向的研究计划。 新冠肺炎大流行进一步突显了对创新影响进行严格评估的必要性 在艾滋病毒护理提供方面，确保使用这些药物不会扩大艾滋病毒健康差距。在此应用程序中，Dr。 Christopoulos提出了一个全面的指导、研究和职业发展计划，以促进 在新冠状病毒感染后的环境中公平提供艾滋病毒护理和治疗。利用的基础设施 CFAR集成临床系统网络(CNICs)和她作为UCSF站点PI的角色，这项研究建议在 这项申请旨在调查艾滋病毒护理和治疗方面的进步的影响，即远程医疗，长期- 采取可注射抗逆转录病毒治疗，防止病毒滞留和病毒抑制。除了以下资源之外 CNICs，其中包括一个指导核心，Christopoulos博士将在Long- 加州大学旧金山分校的代理注射抗逆转录病毒治疗、培训和职业资源，以及强大的 多学科协作者，为学员提供培训机会、初步数据和平台 在此基础上进行新的研究。通过经验丰富的高级指导团队的指导，正式的 授课方式和学员反馈，她将增强和正式化她的指导能力和方法 关于跨越差异的指导和支持代表不足的少数群体的额外培训(URM) 研究人员，在她的指导和研究中建立公平的重点。K24在以下方面非常有用 实现她成为参与艾滋病毒主题的国际领导者的长期职业目标 通过培训专注于她的下一代研究人员来关心和最大限度地发挥她的科学追求的影响 关于优化艾滋病毒护理参与度。

Project Abstract Dr. Christopoulos is an infectious disease physician and Associate Professor of Medicine in the Division of HIV, ID, and Global Medicine at UCSF. Her research over the past ten years has focused on improving engagement in HIV care for underserved urban populations by identifying those at risk for poor engagement, understanding barriers to and facilitators of engagement, and developing interventions to support engagement. She has mentored numerous early career investigators, including pre-doctoral students, post-doctoral fellows, and junior faculty but now seeks the protected time of the K24 award to increase the depth and scope of her mentorship, undertake dedicated mentorship skills training, and grow her program of patient oriented research. The COVID-19 pandemic has highlighted further the need for rigorous evaluation of the impact of innovations in HIV care delivery to ensure their use does not widen HIV health disparities. In this application, Dr. Christopoulos proposes a comprehensive mentoring, research, and career development plan to promote the equitable delivery of HIV care and treatment in a post-COVID landscape. Leveraging the infrastructure of the CFAR Network of Integrated Clinical Systems (CNICS) and her role as UCSF site PI, the research proposed in this application seeks to investigate the impact of advances in HIV care and treatment, i.e., telehealth, long- acting injectable antiretroviral therapy, on retention and viral suppression. In addition to the resources of CNICS, which include a mentoring core, Dr. Christopoulos will utilize an implementation science R01 on long- acting injectable antiretroviral therapy, training and career resources at UCSF, and a robust network of multidisciplinary collaborators to provide mentees with training opportunities, preliminary data, and platforms on which to build new research. Through the guidance of an experienced senior mentoring team, formal didactics, and mentee feedback, she will augment and formalize her mentoring abilities and approach with additional training in mentoring across differences and supporting under-represented minority (URM) investigators, building an equity focus in her mentoring as well as her research. The K24 is instrumental to achieving her long-term career goals of becoming an international leader on the topic of engagement in HIV care and maximizing the impact of her scientific pursuits by training the next generation of researchers focused on optimizing HIV care engagement.