Mentoring Patient-Oriented Research on Advances to Optimize Engagement in HIV Care

指导以患者为中心的研究进展，以优化艾滋病毒护理参与

• 批准号: 10554007
• 负责人: Katerina A Christopoulos
• 金额: $ 19.25万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-08 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10554007
• 关键词: Address; Adherence; Affect; Applications Grants; Area; COVID-19 pandemic; Caring; Clinic; Clinic Visits; Clinical; Code; Communicable Diseases; Communities; Data; Data Collection; Development; Development Plans; Drug resistance; Ensure; Environment; Faculty; Failure; Feedback; Future; Goals; HIV; Health; Healthcare; Home; Homelessness; Impact evaluation; Infrastructure; Injectable; Injections; International; Intervention; Interview; Learning; Measures; Medicine; Mentors; Mentorship; Methods; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Modality; Modeling; Outcome; Patient Outcomes Assessments; Patients; Pattern; Perception; Persons; Physicians; Postdoctoral Fellow; Provider; Qualitative Research; Quality of Care; Research; Research Methodology; Research Personnel; Resources; Risk; Role; Roter; Sampling; Site; Social support; Surveys; Survival Analysis; System; Systems Analysis; Telephone; Time; Training; Underrepresented Minority; Urban Population; Viral; Visit; Work; antiretroviral therapy; base; care delivery; career; career development; data infrastructure; doctoral student; drug development; ethnic minority; experience; health disparity; health equity; housing instability; implementation science; improved; improved outcome; innovation; interest; mid-career faculty; minority investigator; multidisciplinary; multilevel analysis; next generation; pandemic disease; patient oriented; patient oriented research; patient-clinician communication; pill; post-COVID-19; pre-doctoral; programs; psychosocial; racial and ethnic; research and development; shared decision making; skills; skills training; social stigma; substance use; success; telehealth; telehealth systems; therapy development; training opportunity; treatment strategy; urban underserved; video visit; ward

Project Abstract Dr. Christopoulos is an infectious disease physician and Associate Professor of Medicine in the Division of HIV, ID, and Global Medicine at UCSF. Her research over the past ten years has focused on improving engagement in HIV care for underserved urban populations by identifying those at risk for poor engagement, understanding barriers to and facilitators of engagement, and developing interventions to support engagement. She has mentored numerous early career investigators, including pre-doctoral students, post-doctoral fellows, and junior faculty but now seeks the protected time of the K24 award to increase the depth and scope of her mentorship, undertake dedicated mentorship skills training, and grow her program of patient oriented research. The COVID-19 pandemic has highlighted further the need for rigorous evaluation of the impact of innovations in HIV care delivery to ensure their use does not widen HIV health disparities. In this application, Dr. Christopoulos proposes a comprehensive mentoring, research, and career development plan to promote the equitable delivery of HIV care and treatment in a post-COVID landscape. Leveraging the infrastructure of the CFAR Network of Integrated Clinical Systems (CNICS) and her role as UCSF site PI, the research proposed in this application seeks to investigate the impact of advances in HIV care and treatment, i.e., telehealth, long- acting injectable antiretroviral therapy, on retention and viral suppression. In addition to the resources of CNICS, which include a mentoring core, Dr. Christopoulos will utilize an implementation science R01 on long- acting injectable antiretroviral therapy, training and career resources at UCSF, and a robust network of multidisciplinary collaborators to provide mentees with training opportunities, preliminary data, and platforms on which to build new research. Through the guidance of an experienced senior mentoring team, formal didactics, and mentee feedback, she will augment and formalize her mentoring abilities and approach with additional training in mentoring across differences and supporting under-represented minority (URM) investigators, building an equity focus in her mentoring as well as her research. The K24 is instrumental to achieving her long-term career goals of becoming an international leader on the topic of engagement in HIV care and maximizing the impact of her scientific pursuits by training the next generation of researchers focused on optimizing HIV care engagement.

项目摘要 博士克里斯托普洛斯是一名传染病医生和医学系副教授， 艾滋病毒，ID，并在UCSF全球医学。她在过去十年的研究集中在改善 通过查明那些参与程度低的高危人群，参与针对得不到充分服务的城市人口的艾滋病毒护理， 了解参与的障碍和促进因素，并制定干预措施以支持参与。 她指导了许多早期职业调查人员，包括博士预科生，博士后研究员， 和初级教师，但现在寻求K24奖的保护时间，以增加她的深度和范围 导师，进行专门的导师技能培训，并发展她的病人为导向的研究计划。 COVID-19疫情进一步凸显了对创新影响进行严格评估的必要性 在提供艾滋病毒护理方面，确保其使用不会扩大艾滋病毒健康方面的差距。在这个应用程序中，博士。 Christopoulos提出了一个全面的指导，研究和职业发展计划，以促进 在后COVID环境中公平提供艾滋病毒护理和治疗。利用 综合临床系统的CFAR网络（CNICS）和她作为UCSF网站PI的角色， 本申请旨在调查HIV护理和治疗的进展的影响，即，远程保健， 注射抗逆转录病毒疗法，对滞留和病毒抑制。除了资源之外 CNICS包括一个指导核心，Christopoulos博士将利用实施科学R 01对长期 代理注射抗逆转录病毒疗法，在UCSF的培训和职业资源，以及一个强大的网络， 多学科合作者为学员提供培训机会、初步数据和平台 在此基础上进行新的研究。通过经验丰富的高级指导团队的指导， 教学法和学员反馈，她将增强并正式化她的指导能力和方法， 提供更多的培训，以指导不同的群体，并支持代表性不足的少数群体（URM） 调查人员，建立一个公平的重点，在她的指导以及她的研究。K24有助于 实现她的长期职业目标，成为艾滋病毒领域的国际领导者 关心和最大限度地提高她的科学追求的影响，通过培养下一代的研究人员集中 优化艾滋病护理参与。