Testing a Biosocial Model of Borderline Personality Features in Youth

项目摘要 性别不同的青年出生时被指定为女性(AFAB)的自杀相关行为的比率很高， 包括自杀意念、自杀企图和非自杀性自我伤害，这些都与长期和 昂贵的治疗、住院和急诊室就诊。然而，人们对此知之甚少。 不同性别青年AFAB自杀风险深层次的潜在机制，阻碍了 解决这一弱势群体中与自杀有关的个人和社会负担。有必要 归属感是突出的自杀模式的核心，而未能获得密切的、互惠的关系是假设的 引发与自杀有关的行为。由于许多不同性别的年轻人AFAB报告了深刻的孤独，NIMH RDoC依恋和从属关系的社会过程结构可能与理解有主要关联 自杀相关行为的出现。依恋和从属关系缺陷，即对 同伴拒绝暗示和对同伴接受暗示的迟钝反应都与困难有关 与他人建立和维持关系，并与自杀相关的风险相关 行为。然而，大多数工作都依赖于社交过程的自我报告测量，这可能局限于 检测社交过程中涉及的精确缺陷。检验神经的先验前瞻性研究 社会加工过程的改变需要澄清依恋和从属关系缺陷的途径 产生与自杀有关的行为。事实上，新的研究表明，不同性别的年轻人AFAB 与其他性和性别相比，社会功能障碍和自杀相关行为的比率特别高 少数族裔青年团体。作为对NOT-OD-22-030的回应，我们试图批判性地检查性别多样性，使用 发展敏感指标，包括感觉到的性别、性别不满足感和性别 在招募的180名早期青少年AFAB(10-14岁)的临床多样化样本中，不符合 从R21 MH125052和R21 MH124027出发。同伴拒绝和接受加工过程中的神经变化 线索将作为自杀相关行为出现的潜在机制进行测试，测量一年 后来在性别多元化的青年AFAB。还将探讨父母和同龄人的风险和复原力因素。它是 预计这项工作的结果将澄清干预的目标，并指导降低以下风险的努力 不同性别青少年AFAB自杀相关行为研究

Project Summary Gender diverse youth assigned female at birth (AFAB) experience high rates of suicide-related behavior, including suicidal ideation, suicide attempts, and non-suicidal self-injury that are associated with long-term and costly treatment, inpatient hospitalizations, and emergency room visits. Yet very little is known about mechanisms underlying the profound risk for suicide among gender diverse youth AFAB, hindering efforts to address the personal and societal burden associated with suicide in this vulnerable population. The need to belong is central to prominent models of suicide, and failure to acquire close, reciprocal relationships is posited to beget suicide-related behaviors. As many gender diverse youth AFAB report profound loneliness, the NIMH RDoC Social Processes construct of Attachment and Affiliation may be of primary relevance to understanding the emergence of suicide-related behavior. Attachment and Affiliation deficits, namely heightened sensitivity to peer rejection cues and blunted responses to peer acceptance cues, have been associated with difficulties forming and maintaining relationships with others and have also been associated with risk for suicide-related behaviors. However, most work has relied on self-report measures of social processing, which may be limited in detecting the precise deficits involved in social processing. A priori prospective research examining neural alterations in social processing is needed to clarify the pathway through which Attachment and Affiliation deficits beget suicide-related behavior. Indeed, emerging research suggests gender diverse youth AFAB have particularly high rates of social dysfunction and suicide-related behavior compared to other sexual and gender minority youth groups. In response to NOT-OD-22-030, we seek to critically examine gender diversity using developmentally sensitive measures, including felt-gender, gender noncontentedness, and gender nonconformity, in a clinically diverse sample of 180 early adolescent youth AFAB (10-14 years old) recruited from R21 MH125052 and R21 MH124027. Neural alterations in processing of peer rejection and acceptance cues will be tested as mechanisms underlying the emergence of suicide-related behavior measured one year later in gender diverse youth AFAB. Parent and peer risk and resilience factors will also be explored. It is anticipated that findings from this work will clarify targets for intervention and direct efforts to mitigate risk for suicide-related behaviors in gender diverse youth AFAB.