Study of Cognitive Symptoms and Future Time Perspective in Preclinical Alzheimer's Disease

临床前阿尔茨海默病的认知症状和未来时间展望研究

• 批准号: 10556669
• 负责人: Shana D. Stites
• 金额: $ 10.77万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10556669
• 关键词: Administrative Supplement; Affect; Age; Aging; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease model; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Alzheimer’s disease biomarker; American; Amyloid; Atrophic; Award; Behavior; Biological Markers; Brain; Career Choice; Caring; Clinic; Clinical; Clinical assessments; Cognition; Cognitive; Cohort Studies; Data; Decision Making; Dementia; Diagnosis; Disease; Disease Progression; Early Diagnosis; Education; Elderly; Event; Funding; Future; Gender; Generations; Goals; Health; Impaired cognition; Impairment; Individual; Intervention; Knowledge; Learning; Link; Logic; Measures; Memory; Mentored Patient-Oriented Research Career Development Award; Modeling; Nerve Degeneration; Neurobehavioral Manifestations; Outcome; Parents; Participant; Patient Self-Report; Patients; Pennsylvania; Performance; Personal Satisfaction; Persons; Pharmacology; Politics; Positron-Emission Tomography; Prevention; Process; Psychiatry; Psychologist; Psychosocial Assessment and Care; Reporting; Research; Research Personnel; Risk; Role; Sampling; Science; Scientist; Series; Societal Factors; Test Result; Testing; Time; Training Programs; Translations; Uncertainty; Universities; Woman; Work; aging brain; base; clinical practice; cognitive change; cognitive testing; cohort; college; design; experience; functional disability; gender difference; lifestyle intervention; men; novel; older men; older women; parent grant; pre-clinical; professor; protective effect; psychologic; research to practice; response; routine practice; sex; skills; social culture; therapy development

I'm a clinical psychologist and researcher, Clark Scholar, and Assistant Professor in the Department of Psychiatry at University of Pennsylvania. I study sex and gender in Alzheimer's disease (AD) and the promising advances being made in the diagnosis and treatment of AD. Researchers posit a stage of AD called “Preclinical AD,” defined as a condition in which individuals are cognitively unimpaired but have biomarker evidence of AD. In the future, persons with Preclinical AD will be prescribed therapies and other interventions to delay or slow the disease progression. What interventions may be needed and how those interventions might need to be designed hinges on understanding the experience of Preclinical AD, and how that experience might vary based on gender and other sociocultural factors. I study the experiences of AD research participants across the continuum of cognitive decline from unimpaired to moderately cognitively impaired in order to understand what types of psychological care may be needed to support the translation of this model of AD prevention into routine practice. In the parent award I am studying two features central to the experience of living with Preclinical AD: Subjective Cognitive Complaints (SCCs) and Future Time Perspective (FTP). I am examining how a person's knowledge of their AD biomarker result, specifically an amyloid PET scan result, a) affects their SCCs and FTP, b) interacts with reports of SCCs and measures of AD pathology, and c) how changes in FTP affect decision-making. Findings from the parent study will show how SCCs and FTP behave in the Preclinical AD experience. I propose, expanding the parent study, to characterize the influences of gender on SCC, FTP, and decision- making in the Preclinical AD experience. This is important to know as the ways individuals react to uncertainty, report in self-identified men and women on their memory, and plan for their futures can vary for men and women. to examine I will conduct a series of studies how gender – measured via cohort differences in the Greatest, Silent, Boomer Generations – interacts with a) associations between AD biomarker knowledge and SCCs, b) reports of SCCs and measures of AD pathology, and c) associations between FTP and decision-making. What I and researchers can use as SCCs transitional development of interventions that protect wellbeing as FTP discover about how gender operates in the Preclinical AD experience will offer novel data t hat, first, clinicians are currently used to classify stage 2 of Preclinical AD, which is a distinct stage between asymptomatic (stage 1) and mildly impaired (stage 3). predicts an individual's decision-making, such as Second, findings will inform healthand financial planning behaviors. Discovering how gender influences the ways SCCs and FTP behave in the Preclinical AD experience will assure successful translation of Preclinical AD and the model of prevention in AD that it will accompany from research into practice. This project will give me the pilot data I need to compete for R01 funding.

我是一名临床心理学家和研究员，克拉克学者，以及系助理教授。 宾夕法尼亚大学的精神病学。我研究阿尔茨海默病（AD）中的性和性别， 在AD的诊断和治疗方面取得了进展。研究人员将AD的一个阶段称为“临床前” AD”定义为个体认知未受损但具有AD生物标志物证据的病症。 未来，临床前AD患者将接受处方治疗和其他干预措施，以延迟或减缓 疾病的进展。可能需要采取哪些干预措施以及如何采取这些干预措施 设计的关键在于了解临床前AD的经验，以及这种经验如何根据 性别和其他社会文化因素。 我研究了AD研究参与者在认知能力下降的连续体中的经历， 未受损至中度认知受损，以了解可能需要哪些类型的心理护理 需要支持将这种AD预防模式转化为日常实践。在家长奖中， 研究临床前AD患者生活经历的两个核心特征：主观认知主诉 未来时间洞察力（FTP）我在研究一个人对AD生物标志物的了解 结果，特别是淀粉样蛋白PET扫描结果，a）影响其SCC和FTP，B）与SCC报告相互作用 以及AD病理学的测量，以及c）FTP的变化如何影响决策。家长的发现 研究将显示SCC和FTP在临床前AD经验中的表现。 我建议，扩大父母的研究，以表征性别对SCC，FTP和决策的影响- 在临床前AD的经验。了解个人对不确定性的反应方式很重要， 报告 在自我认同的男人和女人中， 对他们的记忆，以及对他们未来的计划可能会因男性和女性而异。 审查 我 将 进行一系列研究 如何通过最大的， 沉默的婴儿潮一代-与a）AD生物标志物知识和SCC之间的关联，B） SCC的报告和AD病理学的测量，和c）FTP和决策之间的关联。什么 我 研究人员可以将其用作SCC 过渡 制定保护福利的干预措施， 发现性别如何在临床前AD经验中发挥作用将为临床医生提供新的数据，首先， 目前用于分类临床前AD的第2阶段，这是一个不同的阶段。 无症状（第1期）和轻度受损（第3期）之间的阶段。 预测个人的决策，例如 其次，调查结果将告知 healthand财务planning规划behaviors行为.发现性别如何影响SCC和FTP的行为方式 临床前AD的经验将确保临床前AD和预防模式的成功转化， 它将伴随着从研究到实践。这个项目将给我的试点数据，我需要竞争 R 01融资