SIREN - Upper Midwest Hub

有效研究和开发针对急性重症或受伤患者的创新治疗方法的能力仍然具有挑战性。许多这些破坏性的疾病很少发生，而治疗的时间敏感性挑战了获得前瞻性知情同意的能力，阻碍了招募大量患者参加临床试验的能力。然而，目前对许多这些破坏性疾病的治疗往往研究不足或不令人满意。为此，创新紧急护理临床试验网络战略（SIREN）提供了一个国家结构，以汇集资源来应对这些挑战并推进紧急护理。在本提案中，我们寻求继续为SIREN网络做出贡献。这些贡献包括大量高质量的患者入组所有资助的临床试验，创新和传播实用，成本效益和伦理进步的急诊护理研究，支持院前和知情同意例外（EFIC）研究程序，以及培训下一代急诊护理临床试验。拟议的上中西部枢纽代表了明尼苏达大学枢纽的增长，扩大了覆盖范围，并纳入了整个中西部的网站，重点是不断增长的农村和远程研究能力。我们的中心在急性重症监护，院前和急诊研究的广泛领域带来了学术深度和广度。中心领导层在急性护理临床研究，院前研究，急性重症监护临床试验知情同意例外的使用方面经验丰富，使我们能够很好地进行网络支持的各种试验，而成功实施SIREN所需的多学科专业与传统学术部门之外的合作安排保持一致。

The ability to effectively study and develop innovative treatments for acute critically ill or injured patients remains challenging. Many of these devastating conditions occur infrequently while time-sensitivity of treatments challenge the capacity to obtain prospective informed consent, impeding the ability to enroll large numbers of patients into clinical trials. Yet, the current therapies for many of these devastating conditions are often understudied or unsatisfactory. To this end, the Strategies to Innovate Emergency Care Clinical Trials network (SIREN) provides a national structure to pool resources to address these challenges and advance emergency care. In this proposal we seek to continue our contributions to the SIREN network. These contributions include high numbers of high quality patient enrollments to all funded clinical trials, innovation and dissemination of pragmatic, cost-effective, and ethical advances in the conduct of emergency care research, support of prehospital and Exception From Informed Consent (EFIC) study procedures, and training of the next generation of emergency care clinical trialists. The proposed Upper Midwest hub represents a growth of the prior University of Minnesota hub, with expanding reach and inclusion of sites across the Midwest with a focus on growing rural and teleresearch capacity. Our hub brings academic depth and breadth across wide domains of acute critical care, pre-hospital and emergency research. Hub leadership is experienced in the spectrum of acute care clinical research, pre-hospital research, the use of Exception from Informed Consent for acute critical care clinical trials, positioning us well to conduct all manner of trials supported by the network, while the multidisciplinary specialties needed to collaborate for successful implementation of SIREN are well aligned with collaborative arrangements beyond traditional academic departments.